hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06300.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPS6KA5 | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | 5 | UniProt NCBI |
| MAPK4 | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | 5 | UniProt NCBI |
| RPS6KA4 | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3915 | 1.86398464173e-05 | 1.0 | RPS6KA5 RPS6KA4 MAPK4 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP481 | 3.69900149365e-05 | 1.0 | RPS6KA5 RPS6KA4 MAPK4 | Insulin signaling |
| WP:WP4566 | 0.000927197171072 | 0.666666666667 | RPS6KA5 RPS6KA4 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0044022 | 0.00140460216025 | 0.666666666667 | RPS6KA5 RPS6KA4 | histone H3S28 kinase activity |
| WP:WP585 | 0.00144101964081 | 0.666666666667 | RPS6KA5 RPS6KA4 | Interferon type I signaling pathways |
| WP:WP5353 | 0.00304949085786 | 0.666666666667 | RPS6KA5 RPS6KA4 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04668 | 0.00339398898617 | 0.666666666667 | RPS6KA5 RPS6KA4 | TNF signaling pathway |
| GO:0035175 | 0.00421361424067 | 0.666666666667 | RPS6KA5 RPS6KA4 | histone H3S10 kinase activity |
| REAC:R-HSA-437239 | 0.00704293704569 | 0.666666666667 | RPS6KA5 RPS6KA4 | Recycling pathway of L1 |
| WP:WP437 | 0.0115871748317 | 0.666666666667 | RPS6KA5 MAPK4 | EGF EGFR signaling pathway |
| KEGG:04010 | 0.0221986078054 | 0.666666666667 | RPS6KA5 RPS6KA4 | MAPK signaling pathway |
| WP:WP382 | 0.0225614433222 | 0.666666666667 | RPS6KA5 RPS6KA4 | MAPK signaling pathway |
| REAC:R-HSA-373760 | 0.0349616412881 | 0.666666666667 | RPS6KA5 RPS6KA4 | L1CAM interactions |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK4 | RPS6KA5 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPS6KA5 | RPS6KA4 | 0.962 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| MAPK4 | RPS6KA4 | 0.953 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RPS6KA5 | huMAP3_01966.1 huMAP3_06300.1 huMAP3_07873.1 huMAP3_09590.1 |
| MAPK4 | huMAP3_01117.1 huMAP3_06300.1 huMAP3_07873.1 huMAP3_09590.1 huMAP3_10134.1 huMAP3_12380.1 |
| RPS6KA4 | huMAP3_01966.1 huMAP3_06300.1 huMAP3_09590.1 huMAP3_14776.1 |