hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06308.1

Complex Portal: CPX-25024

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
SLC12A7	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)	5	UniProt NCBI
ALCAM	CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)	5	UniProt NCBI
SLC12A6	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)	5	UniProt NCBI
KIAA1549	UPF0606 protein KIAA1549	5	UniProt NCBI
LGALS8	Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)	5	UniProt NCBI
KIAA0319L	Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)	5	UniProt NCBI
PTPRK	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	5	UniProt NCBI
SLC15A4	Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)	5	UniProt NCBI
LGALS9	Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)	5	UniProt NCBI
CD58	Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)	5	UniProt NCBI
CD276	CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)	5	UniProt NCBI
PTPRG	Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)	5	UniProt NCBI
HEG1	Protein HEG homolog 1	5	UniProt NCBI
NECTIN1	Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)	5	UniProt NCBI
PTGFRN	Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315)	5	UniProt NCBI
SLC26A2	Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)	5	UniProt NCBI
ITGA1	Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)	5	UniProt NCBI
SLC4A7	Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)	5	UniProt NCBI
LGALS3	Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)	5	UniProt NCBI
ENPP4	Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-425393	3.47538877645e-06	0.277777777778	SLC4A7 SLC26A2 SLC15A4 SLC12A7 SLC12A6	Transport of inorganic cations/anions and amino acids/oligopeptides
REAC:R-HSA-425407	0.000348144295408	0.277777777778	SLC4A7 SLC26A2 SLC15A4 SLC12A7 SLC12A6	SLC-mediated transmembrane transport
WP:WP5078	0.000899382672345	0.166666666667	LGALS9 CD276 LGALS3	T cell modulation in pancreatic cancer
REAC:R-HSA-426117	0.00661349948055	0.111111111111	SLC12A7 SLC12A6	Cation-coupled Chloride cotransporters
KEGG:04514	0.0155458881013	0.166666666667	ALCAM CD276 NECTIN1	Cell adhesion molecules
GO:0015291	0.0323272324011	0.277777777778	SLC4A7 SLC26A2 SLC15A4 SLC12A7 SLC12A6	secondary active transmembrane transporter activity
HPA:0170052	0.0470997668122	0.722222222222	SLC26A2 PTGFRN LGALS9 LGALS8 ENPP4 SLC15A4 KIAA0319L NECTIN1 ALCAM HEG1 CD276 LGALS3 SLC12A7	endometrium 2; glandular cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LGALS3	CD58	0.999	0.088
HEG1	LGALS8	0.999	0.048
SLC26A2	LGALS3	0.999	0.14
LGALS8	SLC4A7	0.999	0.028
LGALS8	CD58	0.999	0.044
LGALS9	SLC4A7	0.998	0.182
LGALS9	SLC12A7	0.998	0.068
LGALS8	SLC12A7	0.997	0.05
LGALS9	SLC12A6	0.997	0.096
LGALS8	SLC12A6	0.997	0.02
LGALS8	CD276	0.997	0.018
LGALS8	PTPRG	0.997	0.048
SLC26A2	LGALS8	0.996	0.046	structurally_consistent (dimer)
LGALS8	KIAA0319L	0.996	0.044
LGALS3	SLC12A7	0.996	0.068
LGALS3	LGALS9	0.995	0.5576
ITGA1	LGALS8	0.994	0.058
LGALS9	CD58	0.994	0.104
LGALS8	PTPRK	0.993
LGALS8	ALCAM	0.993	0.0555
LGALS3	SLC12A6	0.992	0.044
NECTIN1	LGALS8	0.991	0.054
LGALS3	SLC4A7	0.989	0.1
LGALS3	ALCAM	0.989	0.112
KIAA0319L	PTPRK	0.988
KIAA0319L	LGALS9	0.986	0.068
LGALS8	PTGFRN	0.985	0.03
CD276	KIAA0319L	0.985	0.062
ENPP4	LGALS8	0.983	0.046
LGALS3	HEG1	0.982	0.052
SLC12A6	SLC12A7	0.982	0.046
CD58	SLC12A6	0.978	0.062
LGALS8	KIAA1549	0.977	0.068
SLC15A4	LGALS9	0.976	0.094
SLC4A7	SLC12A6	0.972	0.028
HEG1	SLC12A7	0.971	0.062
HEG1	PTPRK	0.969
SLC15A4	LGALS3	0.969	0.092	structurally_consistent (dimer)
HEG1	ITGA1	0.967	0.074
HEG1	ALCAM	0.967	0.04
LGALS3	PTGFRN	0.966	0.0922222222222
LGALS9	ALCAM	0.963	0.438205882353
LGALS3	KIAA1549	0.961	0.0943846153846
SLC26A2	LGALS9	0.961	0.152
LGALS3	KIAA0319L	0.96	0.036
SLC26A2	ALCAM	0.96	0.09
KIAA0319L	SLC12A6	0.96	0.046
ALCAM	PTGFRN	0.956	0.078
SLC4A7	PTPRK	0.956
CD58	SLC4A7	0.956	0.054
NECTIN1	ITGA1	0.955	0.056
HEG1	NECTIN1	0.954	0.052
ALCAM	PTPRK	0.954
CD58	SLC12A7	0.954	0.064
SLC26A2	SLC12A6	0.953	0.062
SLC4A7	ALCAM	0.953	0.132
SLC26A2	SLC15A4	0.952	0.056
KIAA0319L	ALCAM	0.952	0.068
ITGA1	PTGFRN	0.952	0.118
ITGA1	PTPRK	0.951
ITGA1	ALCAM	0.948	0.084
ALCAM	SLC12A7	0.948	0.128
ITGA1	KIAA0319L	0.944	0.05
SLC15A4	SLC12A7	0.943	0.078
SLC15A4	ALCAM	0.94	0.05
ENPP4	ALCAM	0.94	0.074
SLC26A2	CD58	0.939	0.054
SLC15A4	CD58	0.937	0.126
HEG1	KIAA0319L	0.933	0.066
SLC26A2	SLC4A7	0.933	0.078
NECTIN1	PTPRG	0.932	0.088
CD276	PTPRK	0.932
KIAA0319L	SLC4A7	0.932	0.042
ITGA1	CD276	0.931	0.122
SLC26A2	KIAA0319L	0.93	0.074
PTPRG	KIAA0319L	0.929	0.096
SLC12A6	ALCAM	0.927	0.056
CD58	ALCAM	0.915	0.046
SLC26A2	SLC12A7	0.912	0.058
KIAA0319L	SLC12A7	0.908	0.036
HEG1	CD58	0.905	0.088
NECTIN1	PTGFRN	0.901	0.016
LGALS9	PTGFRN	0.901	0.154
SLC15A4	HEG1	0.901	0.096
PTPRG	LGALS9	0.899	0.12
ITGA1	PTPRG	0.899	0.156
KIAA0319L	CD58	0.896	0.096
HEG1	PTPRG	0.895	0.108
LGALS9	PTPRK	0.892
PTPRG	ALCAM	0.89	0.092
SLC15A4	SLC12A6	0.89	0.096
ENPP4	LGALS3	0.886	0.168	structurally_consistent (dimer)
HEG1	SLC4A7	0.881	0.126
NECTIN1	ALCAM	0.871	0.06
PTPRG	PTPRK	0.869
SLC4A7	SLC12A7	0.864	0.076
PTGFRN	PTPRK	0.86
KIAA0319L	PTGFRN	0.854	0.038
ENPP4	PTGFRN	0.852	0.048
HEG1	PTGFRN	0.851	0.062
NECTIN1	CD276	0.845	0.05
LGALS3	PTPRG	0.842	0.168
NECTIN1	KIAA0319L	0.838	0.036
NECTIN1	PTPRK	0.834
SLC15A4	SLC4A7	0.832	0.048
HEG1	SLC12A6	0.829	0.04
PTPRG	SLC12A6	0.793	0.062
ENPP4	ITGA1	0.791	0.078	mutually_exclusive (P17931)
HEG1	CD276	0.783	0.032
LGALS3	LGALS8	0.779	0.032
SLC26A2	HEG1	0.768	0.104
ENPP4	KIAA0319L	0.767	0.09
KIAA1549	PTPRK	0.739
CD276	LGALS9	0.739	0.274
SLC15A4	KIAA0319L	0.725	0.06
ENPP4	LGALS9	0.711	0.082
CD276	ALCAM	0.706	0.106
PTPRG	SLC12A7	0.7	0.058
ALCAM	KIAA1549	0.693	0.08
LGALS8	LGALS9	0.692	0.038	structurally_consistent (dimer)
PTPRG	CD276	0.68	0.088
SLC26A2	PTPRG	0.68	0.094
CD276	PTGFRN	0.667	0.194
PTPRG	CD58	0.642	0.084
ENPP4	SLC4A7	0.633	0.056
ENPP4	CD276	0.632	0.048
PTPRG	SLC4A7	0.627	0.052
LGALS3	CD276	0.624	0.08
HEG1	KIAA1549	0.622	0.09
SLC12A7	PTPRK	0.613
ITGA1	KIAA1549	0.61	0.084
LGALS3	ITGA1	0.596	0.174	structurally_consistent (dimer)
CD276	SLC12A7	0.595	0.05
ITGA1	SLC12A7	0.582	0.058
PTPRG	PTGFRN	0.565	0.036
ENPP4	CD58	0.533	0.058
SLC12A7	KIAA1549	0.518	0.038
CD276	SLC12A6	0.509	0.026
SLC15A4	PTPRG	0.5	0.06
SLC15A4	LGALS8	0.488	0.024
ENPP4	PTPRK	0.469
ITGA1	SLC4A7	0.463	0.046
ENPP4	PTPRG	0.444	0.048
CD276	CD58	0.432	0.088
SLC26A2	KIAA1549	0.43	0.084
ENPP4	SLC12A7	0.422	0.074
SLC4A7	PTGFRN	0.421	0.106
ITGA1	CD58	0.42	0.100583333333
ENPP4	HEG1	0.42	0.072
SLC12A6	PTPRK	0.388
KIAA0319L	KIAA1549	0.384	0.07
SLC12A6	PTGFRN	0.38	0.028
CD58	PTPRK	0.372
SLC26A2	ITGA1	0.371	0.12
PTGFRN	KIAA1549	0.368	0.034
CD276	KIAA1549	0.366	0.104
SLC26A2	ENPP4	0.363	0.076
LGALS9	KIAA1549	0.356	0.084
CD276	SLC4A7	0.352	0.078
CD58	KIAA1549	0.346	0.076
ENPP4	KIAA1549	0.346	0.07
SLC26A2	PTGFRN	0.344	0.042
ENPP4	SLC12A6	0.34	0.052
NECTIN1	KIAA1549	0.33	0.082
SLC4A7	KIAA1549	0.325	0.06
ITGA1	SLC12A6	0.324	0.054
SLC26A2	PTPRK	0.32
NECTIN1	SLC12A7	0.309	0.03
SLC12A6	KIAA1549	0.296	0.068
PTPRG	KIAA1549	0.289	0.078
PTGFRN	SLC12A7	0.254	0.04
CD58	PTGFRN	0.24	0.16
SLC15A4	KIAA1549	0.226	0.088
SLC15A4	ITGA1	0.217	0.026
SLC26A2	NECTIN1	0.216	0.066
ENPP4	SLC15A4	0.187	0.066
ENPP4	NECTIN1	0.17	0.04
NECTIN1	SLC12A6	0.17	0.0466666666667
NECTIN1	SLC4A7	0.163	0.078
NECTIN1	CD58	0.128	0.088
LGALS3	NECTIN1	0.103	0.0663326923077
SLC15A4	PTGFRN	0.099	0.044
SLC26A2	CD276	0.09	0.108
LGALS3	PTPRK	0.055
SLC15A4	PTPRK	0.052
SLC15A4	CD276	0.026	0.052

Related Complexes

Genename	Complexes
SLC12A7	huMAP3_05555.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
ALCAM	huMAP3_02703.1 huMAP3_02887.1 huMAP3_05555.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
SLC12A6	huMAP3_02201.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
KIAA1549	huMAP3_05703.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09130.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11538.1 huMAP3_11739.1 huMAP3_12175.1
LGALS8	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
KIAA0319L	huMAP3_01717.1 huMAP3_02887.1 huMAP3_03801.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_09837.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
PTPRK	huMAP3_06221.1 huMAP3_06308.1 huMAP3_07830.1 huMAP3_08084.1 huMAP3_09105.1 huMAP3_10503.1 huMAP3_10980.1
SLC15A4	huMAP3_01308.1 huMAP3_02818.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11982.1 huMAP3_15126.1
LGALS9	huMAP3_02201.1 huMAP3_04649.1 huMAP3_04870.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_06959.1 huMAP3_07990.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
CD58	huMAP3_02201.1 huMAP3_03234.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_14961.1
CD276	huMAP3_01717.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_05555.1 huMAP3_05626.1 huMAP3_06308.1 huMAP3_07927.1 huMAP3_08689.1 huMAP3_09169.1 huMAP3_09336.1 huMAP3_09837.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10889.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_13596.1 huMAP3_14140.1
PTPRG	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02042.1 huMAP3_02607.1 huMAP3_05632.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08443.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10724.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_12658.1 huMAP3_14792.1
HEG1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15183.1
NECTIN1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_03194.1 huMAP3_04614.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06236.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15075.1
PTGFRN	huMAP3_02703.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_04390.1 huMAP3_04614.1 huMAP3_05555.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
SLC26A2	huMAP3_00454.1 huMAP3_05555.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
ITGA1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_03194.1 huMAP3_04614.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_06955.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15075.1
SLC4A7	huMAP3_02201.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_12418.1
LGALS3	huMAP3_01308.1 huMAP3_01622.1 huMAP3_05555.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_14683.1
ENPP4	huMAP3_01162.1 huMAP3_01717.1 huMAP3_02703.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_04384.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06308.1

Complex Portal: CPX-25024