hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06323.1

Complex Portal: CPX-23713

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PPL	Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)	5	UniProt NCBI
LCP1	Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)	5	UniProt NCBI
FCGBP	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	5	UniProt NCBI
GGCT	Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21)	5	UniProt NCBI
AKR1B10	Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)	5	UniProt NCBI
TYMP	Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)	5	UniProt NCBI
CRABP2	Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)	5	UniProt NCBI
TRIM29	Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)	5	UniProt NCBI
TREX2	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2)	5	UniProt NCBI
EVPL	Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)	5	UniProt NCBI
SULT2B1	Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1)	5	UniProt NCBI
STAT3	Signal transducer and activator of transcription 3 (Acute-phase response factor)	5	UniProt NCBI
SERPINB5	Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)	5	UniProt NCBI
EPPK1	Epiplakin (450 kDa epidermal antigen)	5	UniProt NCBI
HMOX1	Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HPA:0470181	3.84927377028e-05	0.583333333333	PPL HMOX1 SULT2B1 STAT3 EVPL TRIM29 SERPINB5	skin 2; cells in granular layer[>=Low]
HPA:0470182	0.000226116214264	0.5	HMOX1 SULT2B1 STAT3 EVPL TRIM29 SERPINB5	skin 2; cells in granular layer[>=Medium]
HPA:0460181	0.000937183752376	0.5	PPL SULT2B1 STAT3 EVPL TRIM29 SERPINB5	skin 1; cells in granular layer[>=Low]
HPA:0471411	0.00308845360672	0.5	PPL SULT2B1 STAT3 EVPL TRIM29 SERPINB5	skin 2; cells in spinous layer[>=Low]
WP:WP4495	0.00323712429647	0.166666666667	STAT3 HMOX1	IL 10 anti inflammatory signaling pathway
HPA:0460183	0.00399317900028	0.333333333333	TRIM29 SULT2B1 SERPINB5 EVPL	skin 1; cells in granular layer[High]
HPA:0470183	0.00406113347236	0.333333333333	HMOX1 TRIM29 SERPINB5 SULT2B1	skin 2; cells in granular layer[High]
KEGG:05206	0.0108816737765	0.25	HMOX1 STAT3 SERPINB5	MicroRNAs in cancer
HPA:0471412	0.0142038377679	0.416666666667	TRIM29 STAT3 SULT2B1 SERPINB5 EVPL	skin 2; cells in spinous layer[>=Medium]
HPA:0480891	0.0181115484396	0.333333333333	EVPL FCGBP SULT2B1 AKR1B10	small intestine; goblet cells[>=Low]
HPA:0461411	0.0254188364135	0.416666666667	PPL EVPL STAT3 SERPINB5 TRIM29	skin 1; cells in spinous layer[>=Low]
HPA:0461391	0.0495363976676	0.416666666667	TRIM29 STAT3 FCGBP SERPINB5 EVPL	skin 1; cells in basal layer[>=Low]
CORUM:1522	0.0499436884912	0.0833333333333	STAT3	STAT3 homodimer complex
CORUM:7316	0.0499436884912	0.0833333333333	STAT3	NFKB1-STAT3 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
CRABP2	EVPL	0.995	0.168
AKR1B10	EVPL	0.993	0.292
PPL	EVPL	0.992	0.462
TREX2	TRIM29	0.992
HMOX1	EVPL	0.99	0.116
TREX2	SERPINB5	0.989
TREX2	EVPL	0.989
TREX2	HMOX1	0.988
TREX2	PPL	0.987
PPL	TRIM29	0.986	0.232
TYMP	PPL	0.986	0.13
TYMP	EVPL	0.985	0.048
EVPL	TRIM29	0.985	0.232
SERPINB5	PPL	0.983	0.2
STAT3	EVPL	0.983
HMOX1	TRIM29	0.982	0.148363636364
CRABP2	PPL	0.981	0.212
TREX2	CRABP2	0.981
PPL	HMOX1	0.981	0.168
STAT3	SULT2B1	0.98
EVPL	SULT2B1	0.98	0.2
HMOX1	SULT2B1	0.98	0.164
EPPK1	HMOX1	0.978	0.158
TYMP	SERPINB5	0.977	0.118
TREX2	SULT2B1	0.977
STAT3	TRIM29	0.977
PPL	STAT3	0.976
TYMP	STAT3	0.976
EVPL	FCGBP	0.975
CRABP2	SULT2B1	0.973	0.084
FCGBP	SULT2B1	0.973
TYMP	FCGBP	0.973	0.068
CRABP2	FCGBP	0.973	0.018
FCGBP	TRIM29	0.97
AKR1B10	STAT3	0.969
TREX2	STAT3	0.969
TYMP	HMOX1	0.968	0.118
AKR1B10	PPL	0.968	0.142
PPL	SULT2B1	0.967	0.148
EPPK1	SERPINB5	0.967	0.16
PPL	FCGBP	0.966
CRABP2	STAT3	0.966
AKR1B10	SULT2B1	0.965	0.144
TREX2	EPPK1	0.965
SERPINB5	TRIM29	0.964	0.408
STAT3	HMOX1	0.963
GGCT	AKR1B10	0.963	0.168
SERPINB5	EVPL	0.962	0.196
TYMP	LCP1	0.961	0.204
LCP1	TRIM29	0.96	0.162
AKR1B10	TRIM29	0.96	0.162
LCP1	PPL	0.96	0.25
LCP1	EVPL	0.96	0.136
EPPK1	EVPL	0.959	0.086
LCP1	SULT2B1	0.958	0.06
TYMP	AKR1B10	0.957	0.102
LCP1	FCGBP	0.957	0.054
LCP1	CRABP2	0.956	0.118
TREX2	LCP1	0.956
CRABP2	TRIM29	0.954	0.228
TREX2	GGCT	0.954
SERPINB5	FCGBP	0.954
TYMP	TREX2	0.953
AKR1B10	HMOX1	0.952	0.188
EPPK1	FCGBP	0.951	0.076
GGCT	EVPL	0.951	0.052
TYMP	CRABP2	0.951	0.034
TYMP	EPPK1	0.945	0.18
HMOX1	FCGBP	0.944	0.012
AKR1B10	CRABP2	0.943	0.204
TYMP	TRIM29	0.942	0.224
TREX2	AKR1B10	0.941
TRIM29	SULT2B1	0.94	0.14
EPPK1	CRABP2	0.939	0.206
TREX2	FCGBP	0.937
EPPK1	TRIM29	0.937	0.174
SERPINB5	HMOX1	0.934	0.186
EPPK1	PPL	0.932	0.202
TYMP	SULT2B1	0.931	0.084
LCP1	STAT3	0.926
LCP1	HMOX1	0.916	0.15
SERPINB5	SULT2B1	0.907	0.178
CRABP2	HMOX1	0.901	0.09
AKR1B10	FCGBP	0.882	0.282
EPPK1	SULT2B1	0.879	0.112
LCP1	SERPINB5	0.874	0.126
SERPINB5	CRABP2	0.871	0.324
AKR1B10	EPPK1	0.837	0.14
LCP1	AKR1B10	0.797	0.294
AKR1B10	SERPINB5	0.794	0.304
SERPINB5	STAT3	0.79
GGCT	FCGBP	0.724	0.01
STAT3	FCGBP	0.722
EPPK1	STAT3	0.627
GGCT	LCP1	0.541	0.118
LCP1	EPPK1	0.473	0.112
GGCT	HMOX1	0.377	0.074
GGCT	SULT2B1	0.286	0.052
GGCT	PPL	0.244	0.036
GGCT	SERPINB5	0.171	0.128
TYMP	GGCT	0.147	0.074
GGCT	TRIM29	0.144	0.124
GGCT	STAT3	0.084
GGCT	CRABP2	0.064	0.084
GGCT	EPPK1	0.038	0.046

Related Complexes

Genename	Complexes
PPL	huMAP3_03608.1 huMAP3_06046.1 huMAP3_06323.1 huMAP3_07646.1 huMAP3_07972.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1
LCP1	huMAP3_02641.1 huMAP3_06323.1 huMAP3_07761.1 huMAP3_09434.1 huMAP3_10678.1 huMAP3_10900.1
FCGBP	huMAP3_06323.1 huMAP3_07255.1 huMAP3_07761.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1
GGCT	huMAP3_01434.1 huMAP3_02738.1 huMAP3_04424.1 huMAP3_04732.1 huMAP3_05804.1 huMAP3_06323.1 huMAP3_07255.1 huMAP3_07646.1 huMAP3_08429.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1
AKR1B10	huMAP3_02738.1 huMAP3_06323.1 huMAP3_08061.1 huMAP3_10678.1
TYMP	huMAP3_00406.1 huMAP3_05900.1 huMAP3_06323.1 huMAP3_07646.1 huMAP3_08527.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1
CRABP2	huMAP3_03608.1 huMAP3_05900.1 huMAP3_06323.1 huMAP3_07761.1 huMAP3_08527.1 huMAP3_09833.1 huMAP3_09848.1 huMAP3_09929.1 huMAP3_10678.1
TRIM29	huMAP3_06323.1 huMAP3_07646.1 huMAP3_09833.1 huMAP3_10678.1
TREX2	huMAP3_01434.1 huMAP3_03864.1 huMAP3_04424.1 huMAP3_05804.1 huMAP3_06323.1 huMAP3_07255.1 huMAP3_07761.1 huMAP3_08429.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1 huMAP3_13525.1
EVPL	huMAP3_04732.1 huMAP3_06323.1 huMAP3_07255.1 huMAP3_07646.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1
SULT2B1	huMAP3_06323.1 huMAP3_07646.1 huMAP3_09833.1 huMAP3_10678.1
STAT3	huMAP3_03864.1 huMAP3_06323.1 huMAP3_07761.1 huMAP3_09833.1 huMAP3_10678.1 huMAP3_12153.1
SERPINB5	huMAP3_03608.1 huMAP3_03864.1 huMAP3_06323.1 huMAP3_07255.1 huMAP3_07761.1 huMAP3_09125.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1 huMAP3_11636.1
EPPK1	huMAP3_03348.1 huMAP3_06046.1 huMAP3_06323.1 huMAP3_07646.1 huMAP3_09473.1 huMAP3_09833.1 huMAP3_09929.1 huMAP3_10678.1 huMAP3_10813.1 huMAP3_11096.1
HMOX1	huMAP3_03864.1 huMAP3_04862.1 huMAP3_06323.1 huMAP3_07761.1 huMAP3_09833.1 huMAP3_10678.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06323.1

Complex Portal: CPX-23713