hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06340.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZYX | Zyxin (Zyxin-2) | 5 | UniProt NCBI |
| VASP | Vasodilator-stimulated phosphoprotein (VASP) | 5 | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 5 | UniProt NCBI |
| ENAH | Protein enabled homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202433 | 2.8370403595e-06 | 0.75 | EVL VASP ENAH | Generation of second messenger molecules |
| GO:0005522 | 4.61210427592e-05 | 0.75 | EVL VASP ENAH | profilin binding |
| KEGG:04015 | 0.000254854188265 | 0.75 | EVL VASP ENAH | Rap1 signaling pathway |
| REAC:R-HSA-202403 | 0.000269276548599 | 0.75 | EVL VASP ENAH | TCR signaling |
| REAC:R-HSA-376176 | 0.00211233137107 | 0.75 | EVL VASP ENAH | Signaling by ROBO receptors |
| GO:0017124 | 0.0079870728422 | 0.75 | EVL VASP ENAH | SH3 domain binding |
| WP:WP185 | 0.00883615359641 | 0.5 | ZYX VASP | Integrin mediated cell adhesion |
| GO:0007015 | 0.0138903594981 | 1.0 | ZYX VASP ENAH EVL | actin filament organization |
| GO:0005925 | 0.0169270306723 | 1.0 | ZYX VASP ENAH EVL | focal adhesion |
| GO:0030055 | 0.0183121868773 | 1.0 | ZYX VASP ENAH EVL | cell-substrate junction |
| CORUM:6731 | 0.0249718442456 | 0.25 | VASP | VASP-CXCR2 complex, CXCL8 stimulated |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | EVL VASP ENAH | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | EVL VASP ENAH | Nervous system development |
| KEGG:04510 | 0.03673756538 | 0.5 | ZYX VASP | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | ZYX VASP | Focal adhesion |
| CORUM:3160 | 0.049938562206 | 0.25 | VASP | RIAM-VASP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EVL | ENAH | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction | |
| VASP | ENAH | 1.0 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| EVL | VASP | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| ENAH | ZYX | 0.996 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| VASP | ZYX | 0.97 | 0.424 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| EVL | ZYX | 0.057 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes