hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06367.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ANKS1B | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | 5 | UniProt NCBI |
| MICAL1 | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | 5 | UniProt NCBI |
| ARHGAP10 | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | 5 | UniProt NCBI |
| ARHGAP26 | Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) | 5 | UniProt NCBI |
| ARHGAP42 | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | 4 | UniProt NCBI |
| OPHN1 | Oligophrenin-1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013148 | 1.43305165125e-05 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | CDC42 GTPase cycle |
| REAC:R-HSA-8980692 | 1.43305165125e-05 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | RHOA GTPase cycle |
| REAC:R-HSA-9013149 | 3.56561563648e-05 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | RAC1 GTPase cycle |
| REAC:R-HSA-9013404 | 0.000641417793729 | 0.5 | ARHGAP42 ARHGAP26 OPHN1 | RAC2 GTPase cycle |
| REAC:R-HSA-9013423 | 0.000714100505716 | 0.5 | ARHGAP42 ARHGAP26 OPHN1 | RAC3 GTPase cycle |
| REAC:R-HSA-9012999 | 0.00137431571924 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | RHO GTPase cycle |
| REAC:R-HSA-194315 | 0.0087987737143 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00959411672385 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0005096 | 0.0146230100935 | 0.666666666667 | OPHN1 ARHGAP42 ARHGAP10 ARHGAP26 | GTPase activator activity |
| REAC:R-HSA-9013409 | 0.0352499509777 | 0.333333333333 | OPHN1 ARHGAP26 | RHOJ GTPase cycle |
| REAC:R-HSA-9013406 | 0.0352499509777 | 0.333333333333 | OPHN1 ARHGAP26 | RHOQ GTPase cycle |
| REAC:R-HSA-9013026 | 0.0467439411123 | 0.333333333333 | OPHN1 ARHGAP26 | RHOB GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ARHGAP26 | OPHN1 | 0.999 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARHGAP10 | ARHGAP26 | 0.999 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| ARHGAP42 | ARHGAP26 | 0.998 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARHGAP26 | MICAL1 | 0.992 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ANKS1B | ARHGAP26 | 0.965 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARHGAP10 | OPHN1 | 0.902 | 0.252 | bioplex_WMM bioplex3_WMM WMM_only |
| ARHGAP42 | OPHN1 | 0.86 | 0.182 | bioplex_WMM bioplex3_WMM WMM_only |
| ARHGAP42 | ARHGAP10 | 0.741 | 0.25 | bioplex_WMM bioplex3_WMM WMM_only |
| MICAL1 | OPHN1 | 0.671 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only |
| ARHGAP10 | MICAL1 | 0.622 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| ARHGAP42 | MICAL1 | 0.564 | 0.2 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes