hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06372.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPC1 | Glypican-1 [Cleaved into: Secreted glypican-1] | 5 | UniProt NCBI |
| GPR183 | G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2) | 5 | UniProt NCBI |
| CAMKV | CaM kinase-like vesicle-associated protein | 5 | UniProt NCBI |
| CEACAM7 | Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2) | 5 | UniProt NCBI |
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | 5 | UniProt NCBI |
| HBEGF | Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] | 5 | UniProt NCBI |
| FGF1 | Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) | 5 | UniProt NCBI |
| TGFBR3 | Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 0.00505983974502 | 0.25 | GPC4 GPC1 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.00505983974502 | 0.25 | GPC4 GPC1 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-9694614 | 0.00755574884395 | 0.25 | GPC4 GPC1 | Attachment and Entry |
| REAC:R-HSA-4420332 | 0.00849789009901 | 0.25 | GPC4 GPC1 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.00849789009901 | 0.25 | GPC4 GPC1 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 0.00849789009901 | 0.25 | GPC4 GPC1 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-2024096 | 0.0128161014463 | 0.25 | GPC4 GPC1 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.0153043597228 | 0.25 | GPC4 GPC1 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.0209373692109 | 0.25 | GPC4 GPC1 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 0.02920582473 | 0.25 | GPC4 GPC1 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 0.0388325640363 | 0.25 | GPC4 GPC1 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.04306231829 | 0.25 | GPC4 GPC1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.0498119601581 | 0.25 | GPC4 GPC1 | Metabolism of fat-soluble vitamins |
| CORUM:6909 | 0.0499436884912 | 0.125 | FGF1 | FGF1-FGFR1-ITGB3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAMKV | TGFBR3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TGFBR3 | FGF1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPR183 | GPC1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPC4 | GPC1 | 0.99 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GPC1 | FGF1 | 0.989 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAMKV | GPC1 | 0.987 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HBEGF | GPC1 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC4 | CAMKV | 0.985 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GPC1 | CEACAM7 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPR183 | TGFBR3 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GPC4 | HBEGF | 0.973 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC1 | TGFBR3 | 0.967 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| GPC4 | GPR183 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GPC4 | FGF1 | 0.957 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GPC4 | TGFBR3 | 0.926 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes