hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06382.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS11 | Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) | 5 | UniProt NCBI |
| INTS4 | Integrator complex subunit 4 (Int4) | 5 | UniProt NCBI |
| INTS2 | Integrator complex subunit 2 (Int2) | 5 | UniProt NCBI |
| INTS1 | Integrator complex subunit 1 (Int1) | 5 | UniProt NCBI |
| INTS12 | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1153 | 2.07914798001e-14 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | Integrator complex |
| CORUM:1155 | 3.37861546752e-14 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | Integrator-RNAPII complex |
| GO:0032039 | 1.04703057072e-10 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | integrator complex |
| REAC:R-HSA-6807505 | 4.0904328277e-10 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | RNA polymerase II transcribes snRNA genes |
| GO:0016180 | 5.92308831628e-10 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | snRNA processing |
| GO:0016073 | 2.34020517034e-08 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | snRNA metabolic process |
| GO:0034243 | 1.90092506116e-07 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | regulation of transcription elongation by RNA polymerase II |
| GO:0032784 | 5.21719080462e-07 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | regulation of DNA-templated transcription elongation |
| CORUM:1154 | 6.15943912163e-07 | 0.6 | INTS4 INTS11 INTS2 | DSS1 complex |
| GO:0006368 | 6.44022345044e-07 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | transcription elongation by RNA polymerase II |
| GO:0006354 | 1.44420964188e-06 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | DNA-templated transcription elongation |
| GO:0034470 | 0.000388492285819 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | ncRNA processing |
| REAC:R-HSA-73857 | 0.000473207077014 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000887298860527 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | Gene expression (Transcription) |
| GO:0034472 | 0.00127603542925 | 0.6 | INTS2 INTS12 INTS1 | snRNA 3'-end processing |
| GO:0034660 | 0.0026400649682 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | ncRNA metabolic process |
| WP:WP5345 | 0.0132783799217 | 0.4 | INTS4 INTS11 | 1p36 copy number variation syndrome |
| GO:0006396 | 0.0196596851496 | 1.0 | INTS4 INTS1 INTS11 INTS12 INTS2 | RNA processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| INTS1 | INTS12 | 1.0 | 0.49 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| INTS12 | INTS4 | 1.0 | 0.614 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| INTS11 | INTS4 | 0.998 | 0.494 | hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction |
| INTS1 | INTS2 | 0.996 | 0.418 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| INTS4 | INTS2 | 0.994 | 0.492 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS1 | INTS4 | 0.981 | 0.774 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS12 | INTS2 | 0.971 | 0.258 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS11 | INTS2 | 0.891 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| INTS12 | INTS11 | 0.86 | 0.432 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| INTS1 | INTS11 | 0.709 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes