hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06383.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| SRPRA | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | 5 | UniProt NCBI |
| SKIC2 | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | 5 | UniProt NCBI |
| SKIC3 | Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin) | 5 | UniProt NCBI |
| RPS27L | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1168 | 4.09448956317e-05 | 0.4 | SKIC3 SKIC2 | SKI complex |
| HP:0025156 | 0.000192384920571 | 0.4 | SKIC3 SKIC2 | Dependency on intravenous nutrition |
| HP:0030056 | 0.000961529670085 | 0.4 | SKIC3 SKIC2 | Uncombable hair |
| HP:0002041 | 0.001345957274 | 0.4 | SKIC3 SKIC2 | Intractable diarrhea |
| REAC:R-HSA-429958 | 0.0018206657072 | 0.4 | SKIC3 SKIC2 | mRNA decay by 3' to 5' exoribonuclease |
| HP:0009886 | 0.00422725674544 | 0.4 | SKIC3 SKIC2 | Trichorrhexis nodosa |
| HP:0005263 | 0.00768171284681 | 0.4 | SKIC3 SKIC2 | Gastritis |
| HP:0040130 | 0.00768171284681 | 0.4 | SKIC3 SKIC2 | Abnormal serum iron concentration |
| HP:0003139 | 0.00979150178217 | 0.4 | SKIC3 SKIC2 | Panhypogammaglobulinemia |
| KEGG:03018 | 0.0118302702264 | 0.4 | SKIC3 SKIC2 | RNA degradation |
| HP:0011877 | 0.0121560512731 | 0.4 | SKIC3 SKIC2 | Increased mean platelet volume |
| HP:0011031 | 0.0134337956242 | 0.4 | SKIC3 SKIC2 | Abnormality of iron homeostasis |
| GO:0055087 | 0.0140440992017 | 0.4 | SKIC3 SKIC2 | Ski complex |
| GO:0070478 | 0.0140440992017 | 0.4 | SKIC3 SKIC2 | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| HP:0011473 | 0.0147751514018 | 0.4 | SKIC3 SKIC2 | Villous atrophy |
| HP:0011472 | 0.0147751514018 | 0.4 | SKIC3 SKIC2 | Abnormal small intestinal villus morphology |
| HP:0002224 | 0.0147751514018 | 0.4 | SKIC3 SKIC2 | Woolly hair |
| HP:0002884 | 0.0147751514018 | 0.4 | SKIC3 SKIC2 | Hepatoblastoma |
| HP:0011876 | 0.0161800923797 | 0.4 | SKIC3 SKIC2 | Abnormal platelet volume |
| HP:0025129 | 0.0176485923371 | 0.4 | SKIC3 SKIC2 | Abnormal small intestinal mucosa morphology |
| HP:0007513 | 0.0207761643339 | 0.4 | SKIC3 SKIC2 | Generalized hypopigmentation |
| REAC:R-HSA-429914 | 0.0224106525753 | 0.4 | SKIC3 SKIC2 | Deadenylation-dependent mRNA decay |
| HP:0003328 | 0.0337209222644 | 0.4 | SKIC3 SKIC2 | Abnormal hairshaft morphology |
| HP:0000778 | 0.0358235710582 | 0.4 | SKIC3 SKIC2 | Hypoplasia of the thymus |
| HP:0004969 | 0.0448666137641 | 0.4 | SKIC3 SKIC2 | Peripheral pulmonary artery stenosis |
| HP:0025085 | 0.0448666137641 | 0.4 | SKIC3 SKIC2 | Bloody diarrhea |
| HP:0011030 | 0.0448666137641 | 0.4 | SKIC3 SKIC2 | Abnormal blood transition element cation concentration |
| HP:0010515 | 0.0472853555832 | 0.4 | SKIC3 SKIC2 | Aplasia/Hypoplasia of the thymus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKIC3 | SKIC2 | 0.999 | 0.914 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| SKIC2 | SRPRA | 0.98 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SKIC3 | DECR1 | 0.975 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SKIC3 | SRPRA | 0.967 | 0.032 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| RPS27L | SKIC2 | 0.964 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DECR1 | SKIC2 | 0.958 | 0.058 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SKIC3 | RPS27L | 0.956 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DECR1 | SRPRA | 0.826 | 0.048 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DECR1 | RPS27L | 0.348 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| RPS27L | SRPRA | 0.053 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
Related Complexes