hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06395.1
Complex Portal: CPX-22098
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CALD1 | Caldesmon (CDM) | 5 | UniProt NCBI |
| CORO1B | Coronin-1B (Coronin-2) | 5 | UniProt NCBI |
| API5 | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | 5 | UniProt NCBI |
| CTTN | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | 5 | UniProt NCBI |
| TJP2 | Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2) | 5 | UniProt NCBI |
| EFHD2 | EF-hand domain-containing protein D2 (Swiprosin-1) | 4 | UniProt NCBI |
| MAP4 | Microtubule-associated protein 4 (MAP-4) | 5 | UniProt NCBI |
| TJP1 | Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0460201 | 7.23476091751e-05 | 0.75 | TJP2 MAP4 TJP1 CTTN CORO1B CALD1 | skin 1; endothelial cells[>=Low] |
| HPA:0470201 | 9.89280660727e-05 | 0.75 | TJP2 MAP4 TJP1 CTTN CORO1B CALD1 | skin 2; endothelial cells[>=Low] |
| GO:0045296 | 0.000124258387278 | 0.75 | TJP2 CORO1B CTTN CALD1 EFHD2 TJP1 | cadherin binding |
| HPA:0460202 | 0.000475431931966 | 0.625 | CTTN MAP4 TJP1 CALD1 CORO1B | skin 1; endothelial cells[>=Medium] |
| HPA:0470202 | 0.000661523562951 | 0.625 | CTTN MAP4 TJP1 CALD1 CORO1B | skin 2; endothelial cells[>=Medium] |
| GO:0050839 | 0.00121717517376 | 0.75 | TJP2 CORO1B CTTN CALD1 EFHD2 TJP1 | cell adhesion molecule binding |
| KEGG:04530 | 0.0022539548616 | 0.375 | TJP2 CTTN TJP1 | Tight junction |
| REAC:R-HSA-351906 | 0.0030606580132 | 0.25 | TJP2 TJP1 | Apoptotic cleavage of cell adhesion proteins |
| HPA:0570802 | 0.0053611232973 | 0.75 | MAP4 TJP2 TJP1 CTTN EFHD2 CALD1 | testis; sertoli cells[>=Medium] |
| WP:WP4905 | 0.0054959559122 | 0.25 | TJP2 TJP1 | 1q21 1 copy number variation syndrome |
| REAC:R-HSA-2028269 | 0.00949504138694 | 0.25 | TJP2 TJP1 | Signaling by Hippo |
| MIRNA:hsa-miR-34a-5p | 0.00981223022487 | 0.75 | TJP2 MAP4 CORO1B CTTN EFHD2 CALD1 | hsa-miR-34a-5p |
| KEGG:05110 | 0.0126995872637 | 0.25 | TJP2 TJP1 | Vibrio cholerae infection |
| WP:WP5407 | 0.0234061736065 | 0.25 | TJP2 TJP1 | 15q11q13 copy number variation |
| HPA:0461442 | 0.0281391775868 | 0.5 | MAP4 EFHD2 CORO1B CTTN | skin 1; fibrohistiocytic cells[>=Medium] |
| HPA:0470181 | 0.0301716963206 | 0.5 | TJP2 TJP1 CTTN MAP4 | skin 2; cells in granular layer[>=Low] |
| HPA:0570801 | 0.0301814714865 | 0.75 | MAP4 TJP2 TJP1 CTTN EFHD2 CALD1 | testis; sertoli cells[>=Low] |
| REAC:R-HSA-111465 | 0.0328938418336 | 0.25 | TJP2 TJP1 | Apoptotic cleavage of cellular proteins |
| HPA:0461411 | 0.0410997586194 | 0.5 | MAP4 TJP1 CTTN EFHD2 | skin 1; cells in spinous layer[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TJP1 | TJP2 | 0.998 | 0.11 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| CALD1 | EFHD2 | 0.994 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | ||
| CALD1 | CTTN | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | ||
| MAP4 | CALD1 | 0.985 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | ||
| CORO1B | EFHD2 | 0.982 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CALD1 | TJP2 | 0.974 | hein_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| CALD1 | TJP1 | 0.971 | hein_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| EFHD2 | TJP2 | 0.971 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| API5 | CALD1 | 0.962 | bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM | ||
| TJP1 | CTTN | 0.96 | 0.208 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | |
| CALD1 | CORO1B | 0.951 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction | ||
| CTTN | TJP2 | 0.915 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM | |
| MAP4 | CTTN | 0.915 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | ||
| CTTN | EFHD2 | 0.623 | 0.14 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| CORO1B | TJP2 | 0.618 | 0.102 | hein_WMM youn_WMM gupta_WMM WMM_only | |
| TJP1 | EFHD2 | 0.524 | 0.014 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CORO1B | CTTN | 0.468 | 0.326 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM | |
| TJP1 | CORO1B | 0.421 | 0.156 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| API5 | MAP4 | 0.23 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | ||
| API5 | CTTN | 0.036 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM treiber_WMM WMM_only | |
| MAP4 | TJP1 | 0.03 | bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | ||
| MAP4 | EFHD2 | 0.029 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | ||
| MAP4 | CORO1B | 0.019 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | ||
| MAP4 | TJP2 | 0.013 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | ||
| API5 | EFHD2 | 0.007 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| API5 | CORO1B | 0.006 | 0.14 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| API5 | TJP1 | 0.001 | 0.184 | bioplex3_WMM youn_WMM gupta_WMM fraction | |
| API5 | TJP2 | 0.001 | 0.202 | bioplex3_WMM youn_WMM gupta_WMM fraction |
Related Complexes