hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06407.1
Complex Portal: CPX-24247
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNMT | mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | 5 | UniProt NCBI |
| SPOP | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | 5 | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | 5 | UniProt NCBI |
| KPNA6 | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | 5 | UniProt NCBI |
| KIFC1 | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | 5 | UniProt NCBI |
| SREK1IP1 | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | 5 | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | 5 | UniProt NCBI |
| KPNA5 | Importin subunit alpha-6 (Karyopherin subunit alpha-5) | 5 | UniProt NCBI |
| SPOPL | Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 1.33275465027e-05 | 0.444444444444 | KPNA1 NUP50 KPNA5 KPNA6 | Nucleocytoplasmic transport |
| REAC:R-HSA-168276 | 0.000294226035034 | 0.333333333333 | KPNA1 KPNA5 NUP50 | NS1 Mediated Effects on Host Pathways |
| GO:0042564 | 0.000676970649307 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | NLS-dependent protein nuclear import complex |
| GO:0031074 | 0.00132894467527 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | nucleocytoplasmic transport complex |
| REAC:R-HSA-1169408 | 0.00171735643047 | 0.333333333333 | KPNA1 KPNA5 NUP50 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.00223412593886 | 0.333333333333 | KPNA1 KPNA5 NUP50 | Antiviral mechanism by IFN-stimulated genes |
| KEGG:05164 | 0.00380913245762 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | Influenza A |
| GO:0061608 | 0.00450341440411 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | nuclear import signal receptor activity |
| KEGG:05207 | 0.00550570671328 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | Chemical carcinogenesis - receptor activation |
| GO:0006607 | 0.00655807506899 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | NLS-bearing protein import into nucleus |
| GO:0008139 | 0.0123615112794 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | nuclear localization sequence binding |
| GO:0006606 | 0.0148319287105 | 0.444444444444 | KPNA1 NUP50 KPNA5 KPNA6 | protein import into nucleus |
| KEGG:04340 | 0.0166420703476 | 0.222222222222 | SPOP SPOPL | Hedgehog signaling pathway |
| REAC:R-HSA-162587 | 0.0171260552969 | 0.333333333333 | RNMT NUP50 KPNA1 | HIV Life Cycle |
| GO:0051170 | 0.0179204158456 | 0.444444444444 | KPNA1 NUP50 KPNA5 KPNA6 | import into nucleus |
| REAC:R-HSA-168255 | 0.0193707869546 | 0.333333333333 | KPNA1 KPNA5 NUP50 | Influenza Infection |
| WP:WP4249 | 0.0202568688475 | 0.222222222222 | SPOP SPOPL | Hedgehog signaling pathway |
| GO:0140142 | 0.0234426873659 | 0.333333333333 | KPNA1 KPNA5 KPNA6 | nucleocytoplasmic carrier activity |
| REAC:R-HSA-913531 | 0.0318579275589 | 0.333333333333 | KPNA1 KPNA5 NUP50 | Interferon Signaling |
| REAC:R-HSA-168271 | 0.032153801025 | 0.222222222222 | KPNA1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 0.0368028731299 | 0.222222222222 | KPNA1 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-176033 | 0.0443583465173 | 0.222222222222 | KPNA1 NUP50 | Interactions of Vpr with host cellular proteins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KPNA1 | KPNA6 | 1.0 | 0.458 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| KPNA1 | NUP50 | 0.999 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| KIFC1 | NUP50 | 0.999 | 0.062 |
mutually_exclusive (P52292)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| NUP50 | KPNA6 | 0.999 | 0.222 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NUP50 | KPNA5 | 0.998 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| RNMT | KPNA6 | 0.998 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SPOPL | SPOP | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SREK1IP1 | KPNA1 | 0.997 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SPOP | NUP50 | 0.997 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| KPNA1 | RNMT | 0.997 | 0.118 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RNMT | KPNA5 | 0.997 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SPOPL | KPNA5 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SREK1IP1 | KPNA6 | 0.994 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPOP | KPNA5 | 0.994 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KPNA1 | KPNA5 | 0.988 | 0.24 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SPOPL | NUP50 | 0.979 |
mutually_exclusive (O15131)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNMT | NUP50 | 0.97 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| KPNA5 | KPNA6 | 0.967 | 0.23 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SREK1IP1 | KPNA5 | 0.962 | 0.1 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SPOPL | KPNA6 | 0.933 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KPNA1 | KIFC1 | 0.928 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KIFC1 | KPNA6 | 0.894 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KIFC1 | SPOP | 0.741 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| KPNA1 | SPOP | 0.701 | 0.14 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SPOPL | KIFC1 | 0.41 | bioplex3_WMM WMM_only | ||
| SPOPL | KPNA1 | 0.367 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SPOP | KPNA6 | 0.247 | 0.344 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIFC1 | RNMT | 0.212 | 0.054 |
mutually_exclusive (P52292)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SREK1IP1 | NUP50 | 0.177 | 0.13 |
mutually_exclusive (O15131)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KIFC1 | KPNA5 | 0.17 | 0.062 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SPOP | RNMT | 0.097 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPOPL | RNMT | 0.081 |
mutually_exclusive (O15131)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SREK1IP1 | RNMT | 0.002 | 0.05 |
mutually_exclusive (O15131)
|
bioplex3_HCT116 WMM_only |
Related Complexes