hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06412.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt NCBI |
| TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | 5 | UniProt NCBI |
| LIN37 | Protein lin-37 homolog (Antolefinin) | 5 | UniProt NCBI |
| E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | 5 | UniProt NCBI |
| E2F2 | Transcription factor E2F2 (E2F-2) | 5 | UniProt NCBI |
| MCIDAS | Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1362300 | 1.97831742843e-09 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 4.43345168711e-09 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | Transcription of E2F targets under negative control by DREAM complex |
| REAC:R-HSA-1538133 | 2.16411786968e-08 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | G0 and Early G1 |
| REAC:R-HSA-69205 | 2.5402076735e-08 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | G1/S-Specific Transcription |
| REAC:R-HSA-453279 | 1.05210790032e-07 | 0.833333333333 | TFDP2 E2F1 E2F2 E2F5 LIN37 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69236 | 2.35704115547e-07 | 0.666666666667 | TFDP2 E2F2 E2F5 E2F1 | G1 Phase |
| REAC:R-HSA-69231 | 2.35704115547e-07 | 0.666666666667 | TFDP2 E2F2 E2F5 E2F1 | Cyclin D associated events in G1 |
| REAC:R-HSA-69202 | 2.51636763457e-06 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 2.77535713302e-06 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | Cyclin A:Cdk2-associated events at S phase entry |
| WP:WP179 | 4.00505303048e-06 | 0.666666666667 | TFDP2 E2F2 E2F5 E2F1 | Cell cycle |
| REAC:R-HSA-9659787 | 4.79564882828e-06 | 0.5 | TFDP2 E2F2 E2F1 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
| REAC:R-HSA-9661069 | 4.79564882828e-06 | 0.5 | TFDP2 E2F2 E2F1 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
| KEGG:04218 | 6.1704720267e-06 | 0.666666666667 | E2F1 E2F2 E2F5 LIN37 | Cellular senescence |
| KEGG:04110 | 8.36690855792e-06 | 0.666666666667 | TFDP2 E2F2 E2F5 E2F1 | Cell cycle |
| REAC:R-HSA-69206 | 1.62558528405e-05 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | G1/S Transition |
| REAC:R-HSA-69242 | 3.65722772768e-05 | 0.666666666667 | TFDP2 E2F1 E2F5 LIN37 | S Phase |
| REAC:R-HSA-2559585 | 3.83832488858e-05 | 0.5 | TFDP2 E2F2 E2F1 | Oncogene Induced Senescence |
| REAC:R-HSA-9687139 | 4.60302232639e-05 | 0.5 | TFDP2 E2F2 E2F1 | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| REAC:R-HSA-9675126 | 5.46286536752e-05 | 0.5 | TFDP2 E2F2 E2F1 | Diseases of mitotic cell cycle |
| REAC:R-HSA-69278 | 6.34457226533e-05 | 0.833333333333 | TFDP2 E2F1 E2F2 E2F5 LIN37 | Cell Cycle, Mitotic |
| WP:WP5180 | 6.78763147219e-05 | 0.5 | TFDP2 E2F5 LIN37 | DYRK1A involvement regarding cell proliferation in brain development |
| WP:WP45 | 0.000113837945426 | 0.5 | TFDP2 E2F2 E2F1 | G1 to S cell cycle control |
| REAC:R-HSA-1640170 | 0.000178011057657 | 0.833333333333 | TFDP2 E2F1 E2F2 E2F5 LIN37 | Cell Cycle |
| REAC:R-HSA-111448 | 0.00025805759528 | 0.333333333333 | TFDP2 E2F1 | Activation of NOXA and translocation to mitochondria |
| WP:WP2446 | 0.000278673368084 | 0.5 | TFDP2 E2F2 E2F1 | Retinoblastoma gene in cancer |
| REAC:R-HSA-139915 | 0.000928329318648 | 0.333333333333 | TFDP2 E2F1 | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-2559580 | 0.00138048384488 | 0.5 | TFDP2 E2F2 E2F1 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-113501 | 0.00200991204249 | 0.333333333333 | TFDP2 E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| KEGG:05219 | 0.00455187845463 | 0.333333333333 | E2F1 E2F2 | Bladder cancer |
| REAC:R-HSA-113510 | 0.00594265866298 | 0.333333333333 | TFDP2 E2F1 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-2559583 | 0.00604240808777 | 0.5 | TFDP2 E2F2 E2F1 | Cellular Senescence |
| REAC:R-HSA-114452 | 0.0111743831709 | 0.333333333333 | TFDP2 E2F1 | Activation of BH3-only proteins |
| KEGG:05218 | 0.0135980974704 | 0.333333333333 | E2F1 E2F2 | Melanoma |
| REAC:R-HSA-8953750 | 0.0144005758041 | 0.333333333333 | TFDP2 E2F1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-2173796 | 0.0161658624528 | 0.333333333333 | TFDP2 E2F5 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| KEGG:05214 | 0.0163630378499 | 0.333333333333 | E2F1 E2F2 | Glioma |
| KEGG:05223 | 0.0163630378499 | 0.333333333333 | E2F1 E2F2 | Non-small cell lung cancer |
| WP:WP4685 | 0.0176466803728 | 0.333333333333 | E2F1 E2F2 | Melanoma |
| KEGG:05212 | 0.0183465080486 | 0.333333333333 | E2F1 E2F2 | Pancreatic cancer |
| KEGG:05220 | 0.0193802025824 | 0.333333333333 | E2F1 E2F2 | Chronic myeloid leukemia |
| WP:WP4255 | 0.0220152039288 | 0.333333333333 | E2F1 E2F2 | Non small cell lung cancer |
| KEGG:01522 | 0.0237939838034 | 0.333333333333 | E2F1 E2F2 | Endocrine resistance |
| REAC:R-HSA-6791312 | 0.0253617614497 | 0.333333333333 | TFDP2 E2F1 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:05222 | 0.0261678409889 | 0.333333333333 | E2F1 E2F2 | Small cell lung cancer |
| GO:0090575 | 0.0275845262239 | 0.666666666667 | TFDP2 E2F2 E2F5 E2F1 | RNA polymerase II transcription regulator complex |
| KEGG:05215 | 0.0286526780492 | 0.333333333333 | E2F1 E2F2 | Prostate cancer |
| REAC:R-HSA-2173793 | 0.0313533174732 | 0.333333333333 | TFDP2 E2F5 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| WP:WP4263 | 0.0321785953671 | 0.333333333333 | E2F1 E2F2 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-109606 | 0.0339259639772 | 0.333333333333 | TFDP2 E2F1 | Intrinsic Pathway for Apoptosis |
| WP:WP4658 | 0.0388355255908 | 0.333333333333 | E2F1 E2F2 | Small cell lung cancer |
| WP:WP2431 | 0.039710885216 | 0.333333333333 | E2F1 E2F5 | Spinal cord injury |
| GO:0035189 | 0.042122686785 | 0.333333333333 | E2F1 E2F2 | Rb-E2F complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| E2F5 | TFDP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| TFDP2 | E2F2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TFDP2 | E2F1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCIDAS | TFDP2 | 0.985 | bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| LIN37 | E2F5 | 0.983 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LIN37 | TFDP2 | 0.967 | 0.164 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| E2F5 | E2F2 | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | |
| MCIDAS | E2F2 | 0.902 | bioplex3_WMM WMM_only | |
| MCIDAS | E2F5 | 0.892 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| E2F1 | E2F2 | 0.568 | bioplex_WMM bioplex3_WMM WMM_only | |
| E2F5 | E2F1 | 0.541 | bioplex_WMM bioplex3_WMM WMM_only | |
| MCIDAS | E2F1 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes