hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06417.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMELESS | Protein timeless homolog (hTIM) | 5 | UniProt NCBI |
| MCM3 | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | 5 | UniProt NCBI |
| MCM5 | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | 5 | UniProt NCBI |
| CLSPN | Claspin (hClaspin) | 5 | UniProt NCBI |
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | 5 | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | 5 | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | 5 | UniProt NCBI |
| TIPIN | TIMELESS-interacting protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:678 | 1.87066161015e-08 | 0.5 | GINS4 GINS2 GINS3 | GINS complex |
| REAC:R-HSA-176974 | 1.55272913081e-06 | 0.5 | GINS4 GINS2 GINS3 | Unwinding of DNA |
| GO:0000811 | 7.68841921772e-06 | 0.5 | GINS4 GINS2 GINS3 | GINS complex |
| GO:0006261 | 2.31741536755e-05 | 0.833333333333 | GINS4 TIMELESS TIPIN GINS2 GINS3 | DNA-templated DNA replication |
| REAC:R-HSA-69190 | 3.48992434538e-05 | 0.5 | GINS4 GINS2 GINS3 | DNA strand elongation |
| GO:0000228 | 6.51851913963e-05 | 0.833333333333 | GINS4 TIMELESS TIPIN GINS2 GINS3 | nuclear chromosome |
| GO:0006260 | 0.000195002899367 | 0.833333333333 | GINS4 TIMELESS TIPIN GINS2 GINS3 | DNA replication |
| GO:0071162 | 0.000316805542726 | 0.5 | GINS4 GINS2 GINS3 | CMG complex |
| GO:0031261 | 0.00042234232358 | 0.5 | GINS4 GINS2 GINS3 | DNA replication preinitiation complex |
| REAC:R-HSA-5693607 | 0.000819236589251 | 0.5 | TIMELESS TIPIN CLSPN | Processing of DNA double-strand break ends |
| GO:0000076 | 0.00156505859778 | 0.5 | TIMELESS TIPIN CLSPN | DNA replication checkpoint signaling |
| REAC:R-HSA-69239 | 0.00190090644588 | 0.5 | GINS4 GINS2 GINS3 | Synthesis of DNA |
| REAC:R-HSA-5693567 | 0.00209955523641 | 0.5 | TIMELESS TIPIN CLSPN | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00242257327817 | 0.5 | TIMELESS TIPIN CLSPN | Homology Directed Repair |
| GO:0006268 | 0.00254971303757 | 0.5 | GINS4 GINS2 GINS3 | DNA unwinding involved in DNA replication |
| REAC:R-HSA-5693532 | 0.00445044283113 | 0.5 | TIMELESS TIPIN CLSPN | DNA Double-Strand Break Repair |
| REAC:R-HSA-69242 | 0.00453532495717 | 0.5 | GINS4 GINS2 GINS3 | S Phase |
| REAC:R-HSA-69306 | 0.0059397455674 | 0.5 | GINS4 GINS2 GINS3 | DNA Replication |
| REAC:R-HSA-1640170 | 0.00977124360658 | 0.666666666667 | GINS4 CLSPN GINS2 GINS3 | Cell Cycle |
| GO:0043111 | 0.0210651876021 | 0.333333333333 | TIMELESS TIPIN | replication fork arrest |
| GO:0031298 | 0.0210651876021 | 0.333333333333 | TIMELESS TIPIN | replication fork protection complex |
| GO:0032508 | 0.0271028431288 | 0.5 | GINS4 GINS2 GINS3 | DNA duplex unwinding |
| REAC:R-HSA-73894 | 0.0318872588213 | 0.5 | TIMELESS TIPIN CLSPN | DNA Repair |
| GO:0032392 | 0.0446883661999 | 0.5 | GINS4 GINS2 GINS3 | DNA geometric change |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GINS2 | GINS4 | 1.0 | 0.93 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| TIPIN | TIMELESS | 1.0 | 0.216 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| GINS2 | GINS3 | 1.0 | 0.908 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS4 | GINS3 | 1.0 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo fraction |
| MCM3 | MCM5 | 0.999 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| GINS4 | TIMELESS | 0.998 | 0.204 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| GINS4 | TIPIN | 0.997 | 0.09 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| CLSPN | GINS4 | 0.996 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TIPIN | GINS3 | 0.996 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | TIMELESS | 0.995 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| GINS3 | TIMELESS | 0.995 | 0.158 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| MCM3 | GINS4 | 0.994 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM fraction |
| MCM3 | GINS3 | 0.993 | 0.646 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| MCM3 | TIPIN | 0.992 | 0.236 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | TIPIN | 0.988 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| MCM3 | TIMELESS | 0.979 | 0.342 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | GINS3 | 0.978 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| TIPIN | MCM5 | 0.974 | 0.26 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MCM5 | TIMELESS | 0.967 | 0.502 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| MCM3 | CLSPN | 0.965 | 0.384 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| GINS2 | MCM5 | 0.963 | 0.472 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| GINS3 | MCM5 | 0.957 | 0.578 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| GINS4 | MCM5 | 0.953 | 0.328 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction |
| GINS2 | TIMELESS | 0.952 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| MCM3 | GINS2 | 0.879 | 0.302 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| GINS2 | TIPIN | 0.699 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GINS2 | CLSPN | 0.401 | 0.078 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CLSPN | MCM5 | 0.064 | 0.34 | hein_WMM bioplex3_WMM youn_WMM hein () gupta_WMM bioplex_WMM |
Related Complexes