hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06419.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PKD2	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	5	UniProt NCBI
CNGA4	Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4)	5	UniProt NCBI
TRPM4	Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5620916	0.00104246243986	0.666666666667	CNGA4 PKD2	VxPx cargo-targeting to cilium
REAC:R-HSA-5620920	0.00704293704569	0.666666666667	CNGA4 PKD2	Cargo trafficking to the periciliary membrane
GO:0099094	0.00949377645712	1.0	CNGA4 PKD2 TRPM4	ligand-gated monoatomic cation channel activity
GO:0015276	0.0180186629002	1.0	CNGA4 PKD2 TRPM4	ligand-gated monoatomic ion channel activity
GO:0022834	0.0180186629002	1.0	CNGA4 PKD2 TRPM4	ligand-gated channel activity
CORUM:1071	0.0249718442456	0.333333333333	PKD2	PKD2-FPC complex
GO:0034703	0.0343879058955	1.0	CNGA4 PKD2 TRPM4	cation channel complex
CORUM:1927	0.0499402709677	0.333333333333	PKD2	PKD2-PACS1 complex

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TRPM4	CNGA4	0.998		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PKD2	CNGA4	0.957		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TRPM4	PKD2	0.81	0.06	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PKD2	huMAP3_02572.1 huMAP3_06419.1 huMAP3_06570.1 huMAP3_10155.1 huMAP3_10624.1 huMAP3_11804.1 huMAP3_11884.1
CNGA4	huMAP3_06419.1 huMAP3_06570.1 huMAP3_07829.1 huMAP3_09302.1 huMAP3_09734.1 huMAP3_10155.1 huMAP3_11884.1
TRPM4	huMAP3_00454.1 huMAP3_05584.1 huMAP3_06419.1 huMAP3_07829.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10018.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11104.1 huMAP3_11349.1 huMAP3_11884.1