hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06423.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRP1 | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | 5 | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 5 | UniProt NCBI |
| LRP2 | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | 5 | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | 5 | UniProt NCBI |
| LRP4 | Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097242 | 4.72375798258e-06 | 0.8 | LRPAP1 LRP4 LRP1 LRP2 | amyloid-beta clearance |
| KEGG:04979 | 9.90919093578e-06 | 0.6 | LRPAP1 LRP1 LRP2 | Cholesterol metabolism |
| REAC:R-HSA-975634 | 3.07163147334e-05 | 0.6 | LRP8 LRP1 LRP2 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 3.83555767792e-05 | 0.6 | LRP8 LRP1 LRP2 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-2187338 | 0.000235592298974 | 0.6 | LRP8 LRP1 LRP2 | Visual phototransduction |
| GO:0005041 | 0.000349481973524 | 0.6 | LRP8 LRP1 LRP2 | low-density lipoprotein particle receptor activity |
| GO:0045056 | 0.000436807598019 | 0.6 | LRPAP1 LRP1 LRP2 | transcytosis |
| GO:0030228 | 0.000537554131189 | 0.6 | LRP8 LRP1 LRP2 | lipoprotein particle receptor activity |
| REAC:R-HSA-196854 | 0.00194346431817 | 0.6 | LRP8 LRP1 LRP2 | Metabolism of vitamins and cofactors |
| REAC:R-HSA-9709957 | 0.00451677062682 | 0.6 | LRP8 LRP1 LRP2 | Sensory Perception |
| WP:WP5304 | 0.010677250915 | 0.4 | LRPAP1 LRP1 | Cholesterol metabolism |
| GO:0038024 | 0.0126766174236 | 0.6 | LRP8 LRP1 LRP2 | cargo receptor activity |
| GO:1905167 | 0.0140440992017 | 0.4 | LRP1 LRP2 | positive regulation of lysosomal protein catabolic process |
| GO:0001523 | 0.0279690439474 | 0.6 | LRP8 LRP1 LRP2 | retinoid metabolic process |
| GO:0016101 | 0.0310683011928 | 0.6 | LRP8 LRP1 LRP2 | diterpenoid metabolic process |
| GO:0006721 | 0.0457443058639 | 0.6 | LRP8 LRP1 LRP2 | terpenoid metabolic process |
| GO:1904352 | 0.0468008499735 | 0.4 | LRP1 LRP2 | positive regulation of protein catabolic process in the vacuole |
| CORUM:7535 | 0.0498708842806 | 0.2 | LRP1 | CD44-LRP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LRP2 | LRPAP1 | 0.99 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP4 | 0.988 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP8 | LRPAP1 | 0.979 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP2 | LRP1 | 0.575 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP1 | LRP4 | 0.523 | 0.25 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP2 | LRP4 | 0.254 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP4 | 0.196 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP1 | 0.111 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP2 | 0.066 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes