hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06427.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CENPI | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | 5 | UniProt NCBI |
| CENPO | Centromere protein O (CENP-O) (Interphase centromere complex protein 36) | 5 | UniProt NCBI |
| ITGB3BP | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) | 5 | UniProt NCBI |
| CENPK | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) | 5 | UniProt NCBI |
| CENPC | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | 5 | UniProt NCBI |
| CENPT | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | 5 | UniProt NCBI |
| CENPQ | Centromere protein Q (CENP-Q) | 5 | UniProt NCBI |
| ZFX | Zinc finger X-chromosomal protein | 5 | UniProt NCBI |
| CENPH | Centromere protein H (CENP-H) (Interphase centromere complex protein 35) | 5 | UniProt NCBI |
| CENPP | Centromere protein P (CENP-P) | 5 | UniProt NCBI |
| CENPN | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | 5 | UniProt NCBI |
| CENPU | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | 5 | UniProt NCBI |
| CENPX | Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog) | 5 | UniProt NCBI |
| CENPL | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000939 | 1.26290933922e-37 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | inner kinetochore |
| CORUM:1179 | 2.10699549954e-33 | 0.846153846154 | ITGB3BP CENPP CENPT CENPU CENPQ CENPO CENPK CENPN CENPH CENPC CENPL | CENP-A NAC-CAD complex |
| CORUM:7394 | 1.44667155072e-30 | 0.769230769231 | ITGB3BP CENPL CENPP CENPU CENPI CENPH CENPQ CENPN CENPK CENPO | CENP-H-I complex |
| REAC:R-HSA-774815 | 8.0918651751e-30 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | Nucleosome assembly |
| REAC:R-HSA-606279 | 8.0918651751e-30 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-73886 | 2.34401790357e-25 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | Chromosome Maintenance |
| REAC:R-HSA-141424 | 6.49641415066e-24 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 6.49641415066e-24 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 4.98795507072e-23 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 8.83626355044e-23 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | EML4 and NUDC in mitotic spindle formation |
| GO:0000776 | 1.20538575019e-22 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | kinetochore |
| GO:0000779 | 1.78267773069e-22 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | condensed chromosome, centromeric region |
| REAC:R-HSA-2500257 | 2.09165363994e-22 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 6.23269493996e-22 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | RHO GTPases Activate Formins |
| GO:0000775 | 1.51916695712e-20 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | chromosome, centromeric region |
| GO:0000793 | 2.59742431983e-20 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | condensed chromosome |
| REAC:R-HSA-2467813 | 3.87948664049e-20 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 7.94750321553e-20 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 4.14821571922e-19 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 4.38273958023e-19 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 6.46425708254e-18 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Cell Cycle Checkpoints |
| GO:0098687 | 1.00132893746e-17 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | chromosomal region |
| GO:0007059 | 1.18108432728e-17 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | chromosome segregation |
| REAC:R-HSA-195258 | 1.33154702117e-17 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 3.4845018134e-16 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | M Phase |
| REAC:R-HSA-1640170 | 6.10254424794e-16 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | Cell Cycle |
| CORUM:7388 | 6.57179580752e-15 | 0.461538461538 | CENPT CENPI CENPL CENPC CENPN CENPH | CENP-A nucleosomal complex |
| REAC:R-HSA-69278 | 1.43690321658e-14 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Cell Cycle, Mitotic |
| CORUM:929 | 1.82009259025e-14 | 0.538461538462 | CENPL CENPU CENPI CENPH CENPC CENPK CENPO | CEN complex |
| CORUM:927 | 7.80900880046e-14 | 0.384615384615 | CENPN CENPH CENPU CENPC CENPT | CENP-A NAC complex |
| REAC:R-HSA-194315 | 1.27011201694e-13 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 1.65571980357e-13 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0099080 | 5.57935158277e-12 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | supramolecular complex |
| GO:0022402 | 2.57115708943e-11 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | cell cycle process |
| GO:0007049 | 6.5873191791e-10 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | cell cycle |
| GO:0005694 | 2.64323694442e-09 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | chromosome |
| REAC:R-HSA-162582 | 1.50002870075e-07 | 0.923076923077 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPQ CENPL CENPN CENPH CENPK CENPO | Signal Transduction |
| CORUM:6146 | 0.000245952888523 | 0.153846153846 | CENPT CENPX | CENP-T-W-S-X heterotetramer complex |
| GO:0005654 | 0.000642773776147 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | nucleoplasm |
| GO:0043228 | 0.000910415812014 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | non-membrane-bounded organelle |
| GO:0043232 | 0.000910415812014 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | intracellular non-membrane-bounded organelle |
| GO:0031981 | 0.00148875347378 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | nuclear lumen |
| GO:0051383 | 0.0152921671063 | 0.230769230769 | CENPH CENPC CENPT | kinetochore organization |
| GO:0070013 | 0.0244298182677 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | intracellular organelle lumen |
| GO:0043233 | 0.0244298182677 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | organelle lumen |
| GO:0031974 | 0.0244298182677 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | membrane-enclosed lumen |
| GO:0032991 | 0.0292789767838 | 1.0 | ITGB3BP CENPP CENPT CENPU CENPI CENPC CENPX CENPQ CENPL CENPN CENPH CENPK CENPO | protein-containing complex |
| GO:0034508 | 0.0362257557392 | 0.230769230769 | CENPT CENPI CENPC | centromere complex assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| CENPO | CENPP | 1.0 | 0.376 |
| CENPK | CENPH | 1.0 | 0.43 |
| ITGB3BP | CENPP | 1.0 | 0.298 |
| CENPU | ITGB3BP | 1.0 | 0.25 |
| CENPH | CENPI | 1.0 | 0.328 |
| CENPQ | CENPP | 1.0 | 0.302 |
| CENPU | CENPQ | 1.0 | 0.524 |
| CENPO | ITGB3BP | 0.999 | 0.218 |
| CENPU | CENPO | 0.999 | 0.364 |
| CENPU | CENPP | 0.999 | 0.212 |
| CENPO | CENPQ | 0.999 | 0.462 |
| ITGB3BP | CENPQ | 0.999 | 0.302 |
| CENPK | CENPI | 0.999 | 0.206 |
| CENPU | CENPI | 0.999 | 0.268 |
| ITGB3BP | CENPT | 0.998 | 0.156 |
| CENPU | CENPT | 0.998 | 0.19 |
| CENPP | CENPH | 0.998 | 0.284 |
| CENPN | ITGB3BP | 0.998 | 0.21 |
| CENPQ | CENPI | 0.998 | 0.316 |
| CENPC | CENPI | 0.998 | 0.192 |
| CENPN | CENPQ | 0.998 | 0.286 |
| CENPN | CENPI | 0.998 | 0.238 |
| CENPO | CENPT | 0.997 | 0.36 |
| CENPO | CENPI | 0.996 | 0.256 |
| CENPT | CENPQ | 0.996 | 0.172 |
| CENPN | CENPU | 0.996 | 0.322 |
| CENPN | CENPO | 0.996 | 0.38 |
| CENPC | CENPN | 0.996 | 0.224 |
| CENPU | CENPH | 0.996 | 0.194 |
| CENPC | CENPU | 0.996 | 0.21 |
| CENPT | CENPH | 0.995 | 0.26 |
| CENPU | CENPX | 0.995 | 0.168 |
| ITGB3BP | CENPH | 0.995 | 0.196 |
| CENPC | CENPQ | 0.995 | 0.134 |
| CENPQ | CENPX | 0.994 | 0.124 |
| CENPO | CENPX | 0.994 | 0.156 |
| CENPC | CENPO | 0.994 | 0.182 |
| CENPN | CENPT | 0.993 | 0.218 |
| ITGB3BP | CENPX | 0.993 | 0.106 |
| CENPC | CENPT | 0.993 | 0.15 |
| CENPO | CENPH | 0.993 | 0.172 |
| ITGB3BP | CENPI | 0.993 | 0.206 |
| CENPQ | CENPH | 0.992 | 0.424 |
| CENPP | CENPX | 0.991 | 0.152 |
| CENPP | CENPI | 0.99 | 0.156 |
| CENPT | CENPI | 0.99 | 0.168 |
| CENPN | CENPH | 0.989 | 0.228 |
| CENPL | CENPQ | 0.988 | 0.176 |
| CENPN | CENPP | 0.985 | 0.258 |
| CENPT | CENPP | 0.984 | 0.138 |
| ZFX | CENPU | 0.983 | 0.138 |
| CENPC | CENPP | 0.982 | 0.152 |
| CENPC | ITGB3BP | 0.981 | 0.09 |
| ZFX | CENPI | 0.973 | 0.108 |
| CENPL | CENPI | 0.966 | 0.218 |
| CENPC | CENPH | 0.965 | 0.058 |
| ITGB3BP | CENPK | 0.965 | 0.194 |
| CENPC | CENPL | 0.964 | 0.242 |
| CENPO | CENPK | 0.962 | 0.264 |
| CENPU | CENPK | 0.962 | 0.228 |
| CENPN | CENPL | 0.961 | 0.276 |
| CENPQ | CENPK | 0.96 | 0.352 |
| CENPU | CENPL | 0.956 | 0.216 |
| CENPC | CENPK | 0.946 | 0.154 |
| CENPC | ZFX | 0.94 | 0.098 |
| CENPL | CENPO | 0.938 | 0.308 |
| CENPL | ITGB3BP | 0.931 | 0.22 |
| ZFX | CENPO | 0.925 | 0.118 |
| ZFX | CENPN | 0.898 | 0.1 |
| CENPX | CENPH | 0.886 | 0.212 |
| ZFX | ITGB3BP | 0.852 | 0.118 |
| ZFX | CENPQ | 0.845 | 0.098 |
| CENPC | CENPX | 0.796 | 0.064 |
| CENPP | CENPK | 0.785 | 0.22 |
| CENPT | CENPK | 0.785 | 0.166 |
| CENPN | CENPK | 0.785 | 0.224 |
| CENPL | CENPH | 0.765 | 0.252 |
| CENPT | CENPX | 0.764 | 0.166 |
| CENPX | CENPI | 0.764 | 0.124 |
| CENPN | CENPX | 0.764 | 0.134 |
| CENPX | CENPK | 0.764 | 0.226 |
| ZFX | CENPK | 0.232 | 0.118 |
| ZFX | CENPP | 0.232 | 0.112 |
| ZFX | CENPX | 0.232 | 0.062 |
| ZFX | CENPT | 0.232 | 0.104 |
| ZFX | CENPH | 0.232 | 0.112 |
| CENPL | CENPT | 0.192 | 0.16 |
| CENPL | CENPK | 0.192 | 0.182 |
| CENPL | CENPP | 0.192 | 0.294 |
| CENPL | CENPX | 0.192 | 0.134 |
| ZFX | CENPL | 0.135 | 0.09 |
Related Complexes