hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06443.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SDE2 | Splicing regulator SDE2 (Replication stress response regulator SDE2) | 5 | UniProt NCBI |
| MAGOH | Protein mago nashi homolog | 5 | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | 5 | UniProt NCBI |
| MAGOHB | Protein mago nashi homolog 2 | 5 | UniProt NCBI |
| RBM8A | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:755 | 2.80175822576e-08 | 0.6 | MAGOH RBM8A PYM1 | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM) |
| KEGG:03015 | 3.39757204201e-07 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | mRNA surveillance pathway |
| KEGG:03013 | 5.18747173605e-07 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | Nucleocytoplasmic transport |
| GO:0035145 | 6.36865069892e-07 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | exon-exon junction complex |
| GO:1990501 | 9.61200410764e-07 | 0.6 | MAGOH MAGOHB RBM8A | exon-exon junction subcomplex mago-y14 |
| GO:1903503 | 9.61200410764e-07 | 0.6 | MAGOH MAGOHB RBM8A | ATPase inhibitor complex |
| GO:0000184 | 5.37501604002e-06 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| CORUM:773 | 1.36501667663e-05 | 0.4 | MAGOH RBM8A | Y14-Magoh complex |
| CORUM:763 | 1.36501667663e-05 | 0.4 | MAGOH RBM8A | Y14-Magoh complex |
| REAC:R-HSA-72163 | 2.78873163091e-05 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 3.19999178813e-05 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | mRNA Splicing |
| CORUM:1293 | 4.09448956317e-05 | 0.4 | MAGOH RBM8A | IPO13-RBM8A-MAGOH complex |
| REAC:R-HSA-72187 | 8.14372399533e-05 | 0.6 | MAGOH MAGOHB RBM8A | mRNA 3'-end processing |
| CORUM:769 | 8.18785830799e-05 | 0.4 | MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:754 | 8.18785830799e-05 | 0.4 | MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14) |
| CORUM:744 | 8.18785830799e-05 | 0.4 | MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:740 | 8.18785830799e-05 | 0.4 | MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| REAC:R-HSA-72203 | 9.66841881558e-05 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-73856 | 0.000123167229073 | 0.6 | MAGOH MAGOHB RBM8A | RNA Polymerase II Transcription Termination |
| GO:2000622 | 0.000158467845213 | 0.6 | MAGOH MAGOHB RBM8A | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| REAC:R-HSA-159236 | 0.000169658686915 | 0.6 | MAGOH MAGOHB RBM8A | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:6742 | 0.000204640425412 | 0.4 | MAGOH RBM8A | SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex |
| REAC:R-HSA-72202 | 0.000244866764891 | 0.6 | MAGOH MAGOHB RBM8A | Transport of Mature Transcript to Cytoplasm |
| CORUM:785 | 0.000286457379015 | 0.4 | MAGOH RBM8A | Exon junction complex |
| KEGG:03040 | 0.0002928242891 | 0.6 | MAGOH MAGOHB RBM8A | Spliceosome |
| REAC:R-HSA-975957 | 0.00074191010701 | 0.6 | MAGOH MAGOHB RBM8A | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.00074191010701 | 0.6 | MAGOH MAGOHB RBM8A | Nonsense-Mediated Decay (NMD) |
| GO:0000956 | 0.000812283184782 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-9010553 | 0.00229748232928 | 0.6 | MAGOH MAGOHB RBM8A | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-8953854 | 0.00371793814615 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | Metabolism of RNA |
| GO:0016071 | 0.00384557561421 | 1.0 | RBM8A SDE2 PYM1 MAGOHB MAGOH | mRNA metabolic process |
| REAC:R-HSA-376176 | 0.00464799867734 | 0.6 | MAGOH MAGOHB RBM8A | Signaling by ROBO receptors |
| WP:WP5362 | 0.00687274586933 | 0.4 | MAGOH PYM1 | TAR syndrome |
| GO:0006402 | 0.00893796193013 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | mRNA catabolic process |
| HPA:0330223 | 0.011424797654 | 0.8 | SDE2 PYM1 RBM8A MAGOH | oral mucosa; squamous epithelial cells[High] |
| GO:0006401 | 0.0199678668185 | 0.8 | MAGOH RBM8A MAGOHB PYM1 | RNA catabolic process |
| GO:0000398 | 0.0264444778619 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | mRNA splicing, via spliceosome |
| GO:0000377 | 0.0264444778619 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.0280745884658 | 0.8 | SDE2 RBM8A MAGOHB MAGOH | RNA splicing, via transesterification reactions |
| CORUM:1181 | 0.0395319616948 | 0.4 | MAGOH RBM8A | C complex spliceosome |
| GO:0006406 | 0.0437005530348 | 0.6 | MAGOH MAGOHB RBM8A | mRNA export from nucleus |
| HPA:0190223 | 0.0455701736828 | 0.8 | SDE2 PYM1 RBM8A MAGOH | esophagus; squamous epithelial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAGOH | RBM8A | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| MAGOH | PYM1 | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RBM8A | PYM1 | 0.996 | 0.096 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| MAGOH | MAGOHB | 0.994 | hein_WMM bioplex3_WMM hein () gupta_WMM | |
| RBM8A | SDE2 | 0.991 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| RBM8A | MAGOHB | 0.983 | 0.946 | hein_WMM bioplex3_WMM hein () gupta_WMM |
| PYM1 | MAGOHB | 0.854 | 0.1 | hein_WMM bioplex3_WMM hein () |
| MAGOH | SDE2 | 0.353 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SDE2 | MAGOHB | 0.179 | 0.224 | hein_WMM bioplex3_WMM WMM_only |
| SDE2 | PYM1 | 0.032 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes