hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06453.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | 5 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090110 | 2.96127975816e-14 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | COPII-coated vesicle cargo loading |
| GO:0030127 | 2.96127975816e-14 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | COPII vesicle coat |
| WP:WP1982 | 5.80699737942e-13 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | Sterol regulatory element binding proteins SREBP signaling |
| GO:0070971 | 8.51367930471e-13 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | endoplasmic reticulum exit site |
| GO:0035459 | 2.72269483219e-12 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle cargo loading |
| GO:0090114 | 1.20648594511e-11 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | COPII-coated vesicle budding |
| REAC:R-HSA-983170 | 1.60149771012e-11 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 1.60149771012e-11 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Cargo concentration in the ER |
| GO:0012507 | 4.53788462633e-11 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | ER to Golgi transport vesicle membrane |
| KEGG:04141 | 6.95239973135e-11 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | Protein processing in endoplasmic reticulum |
| GO:0030120 | 1.34190392241e-10 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle coat |
| REAC:R-HSA-1655829 | 4.19761205869e-10 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0006900 | 5.77756138483e-10 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle budding from membrane |
| GO:0030134 | 6.29495494168e-10 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | COPII-coated ER to Golgi transport vesicle |
| REAC:R-HSA-204005 | 1.17788247364e-09 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | COPII-mediated vesicle transport |
| GO:0048475 | 1.8673715483e-09 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | coated membrane |
| GO:0030117 | 1.8673715483e-09 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | membrane coat |
| GO:0030658 | 1.04048949275e-08 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | transport vesicle membrane |
| GO:0006888 | 1.21851216851e-08 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-9705671 | 2.64838246794e-08 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-2132295 | 3.30671765569e-08 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | MHC class II antigen presentation |
| REAC:R-HSA-8957322 | 4.08980754644e-08 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Metabolism of steroids |
| GO:0030662 | 4.6735613044e-08 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | coated vesicle membrane |
| REAC:R-HSA-199977 | 9.14976149591e-08 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 2.32738499526e-07 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-9705683 | 3.64586325736e-07 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | SARS-CoV-2-host interactions |
| GO:0030135 | 5.90196021447e-07 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | coated vesicle |
| GO:0030133 | 1.23875416936e-06 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | transport vesicle |
| GO:0048193 | 1.8815358051e-06 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | Golgi vesicle transport |
| REAC:R-HSA-9694516 | 2.382222328e-06 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | SARS-CoV-2 Infection |
| GO:0016050 | 2.39621111688e-06 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle organization |
| REAC:R-HSA-446203 | 2.85376278052e-06 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Asparagine N-linked glycosylation |
| REAC:R-HSA-983169 | 7.81805966072e-06 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-9679506 | 1.18552046474e-05 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | SARS-CoV Infections |
| KEGG:05130 | 1.19511029976e-05 | 0.666666666667 | SEC24B SEC24D SEC24C SEC24A | Pathogenic Escherichia coli infection |
| CORUM:7139 | 1.70876175213e-05 | 0.333333333333 | SEC24B SEC23A | SEC23-SEC24 adaptor complex |
| REAC:R-HSA-199991 | 9.7213397673e-05 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Membrane Trafficking |
| CORUM:7140 | 0.000102488289015 | 0.333333333333 | SEC24B SEC23A | SEC23-SEC24-SCAP-SREBP1c complex |
| REAC:R-HSA-5653656 | 0.000127442072623 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Vesicle-mediated transport |
| REAC:R-HSA-556833 | 0.000134957179754 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Metabolism of lipids |
| GO:0061024 | 0.000162684444082 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | membrane organization |
| CORUM:7141 | 0.000170782642132 | 0.333333333333 | SEC24B SEC23A | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| REAC:R-HSA-1280218 | 0.00020253555583 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Adaptive Immune System |
| REAC:R-HSA-9824446 | 0.000269027682904 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Viral Infection Pathways |
| TF:M11235_1 | 0.000316805542726 | 0.5 | SEC24A SEC23A SEC24D | Factor: OASIS; motif: YGCCACGTCANC; match class: 1 |
| REAC:R-HSA-5663205 | 0.000749154054491 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Infectious disease |
| GO:0000149 | 0.000792088897246 | 0.666666666667 | SEC24B SEC24D SEC24C SEC24A | SNARE binding |
| GO:0008270 | 0.000862411909616 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | zinc ion binding |
| GO:0030659 | 0.000903164632246 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | cytoplasmic vesicle membrane |
| GO:0012506 | 0.00099360007814 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle membrane |
| GO:0098796 | 0.00312436057741 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | membrane protein complex |
| HP:0002868 | 0.00388470114881 | 0.333333333333 | SEC23A SEC24D | Narrow iliac wing |
| REAC:R-HSA-597592 | 0.00433380037126 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Post-translational protein modification |
| GO:0046914 | 0.00467641244227 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | transition metal ion binding |
| GO:0046907 | 0.008082403103 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | intracellular transport |
| GO:0016192 | 0.00887756788753 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | vesicle-mediated transport |
| REAC:R-HSA-1643685 | 0.0108707096527 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Disease |
| REAC:R-HSA-168256 | 0.0203260039291 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Immune System |
| REAC:R-HSA-392499 | 0.0215959266916 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Metabolism of proteins |
| REAC:R-HSA-1430728 | 0.0258573248266 | 0.833333333333 | SEC24B SEC24D SEC24C SEC24A SEC23A | Metabolism |
| GO:0005783 | 0.0353957491943 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | endoplasmic reticulum |
| GO:0051649 | 0.0361725108126 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | establishment of localization in cell |
| GO:0098588 | 0.046464555054 | 1.0 | SEC24A SEC24B SEC24C SEC23A SEC23B SEC24D | bounding membrane of organelle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC23B | SEC24A | 1.0 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23B | SEC24C | 1.0 | 0.268 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24C | 1.0 | 0.53 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24A | 1.0 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23B | SEC24B | 0.999 | 0.102 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24B | 0.999 | 0.286666666667 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC24B | SEC24A | 0.996 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SEC23B | SEC24D | 0.993 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC24C | SEC24B | 0.992 | 0.27 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SEC24C | SEC24A | 0.991 | 0.386 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23A | SEC24D | 0.981 | 0.302631578947 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24A | 0.963 | 0.266 | bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24C | 0.602 | 0.136 | bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24B | 0.342 | 0.116 | bioplex_WMM bioplex3_WMM fraction |
Related Complexes