hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06467.1
Complex Portal: CPX-12437
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HECW2 | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| NDFIP2 | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) | 5 | UniProt NCBI |
| WBP1 | WW domain-binding protein 1 (WBP-1) | 3 | UniProt NCBI |
| NEDD4L | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | 5 | UniProt NCBI |
| NEDD4 | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | 5 | UniProt NCBI |
| LDLRAD4 | Low-density lipoprotein receptor class A domain-containing protein 4 | 5 | UniProt NCBI |
| ENTREP3 | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4904 | 0.000373625217643 | 0.285714285714 | NEDD4 LDLRAD4 | LDLRAD4 and what we know about it |
| GO:0050699 | 0.0032492156641 | 0.428571428571 | NDFIP2 ENTREP3 WBP1 | WW domain binding |
| GO:0048814 | 0.016587316136 | 0.428571428571 | NEDD4L HECW2 NEDD4 | regulation of dendrite morphogenesis |
| REAC:R-HSA-983168 | 0.045519996482 | 0.428571428571 | NEDD4L HECW2 NEDD4 | Antigen processing: Ubiquitination & Proteasome degradation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LDLRAD4 | HECW2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ENTREP3 | HECW2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | ENTREP3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4L | ENTREP3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | LDLRAD4 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | NEDD4L | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| NEDD4 | NDFIP2 | 0.989 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4 | HECW2 | 0.985 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NEDD4L | LDLRAD4 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | WBP1 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NEDD4L | WBP1 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NEDD4L | HECW2 | 0.966 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only | |
| NEDD4L | NDFIP2 | 0.955 | 0.058 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HECW2 | WBP1 | 0.949 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NDFIP2 | WBP1 | 0.278 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ENTREP3 | NDFIP2 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HECW2 | NDFIP2 | 0.106 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes