hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06470.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | 5 | UniProt NCBI |
| GLCE | D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) | 5 | UniProt NCBI |
| CHST9 | Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2) | 5 | UniProt NCBI |
| GABRQ | Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) | 5 | UniProt NCBI |
| HLA-DRA | HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 0.000616938529993 | 0.4 | HLA-DRB5 HLA-DRA | Asthma |
| WP:WP4884 | 0.000704478690725 | 0.4 | HLA-DRB5 HLA-DRA | Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex |
| REAC:R-HSA-202430 | 0.0011839189519 | 0.4 | HLA-DRB5 HLA-DRA | Translocation of ZAP-70 to Immunological synapse |
| KEGG:05330 | 0.0015900664359 | 0.4 | HLA-DRB5 HLA-DRA | Allograft rejection |
| KEGG:04672 | 0.00171214467432 | 0.4 | HLA-DRB5 HLA-DRA | Intestinal immune network for IgA production |
| REAC:R-HSA-202427 | 0.00206313859056 | 0.4 | HLA-DRB5 HLA-DRA | Phosphorylation of CD3 and TCR zeta chains |
| KEGG:05332 | 0.00210534424221 | 0.4 | HLA-DRB5 HLA-DRA | Graft-versus-host disease |
| REAC:R-HSA-389948 | 0.00232071308473 | 0.4 | HLA-DRB5 HLA-DRA | PD-1 signaling |
| KEGG:04940 | 0.00269245905375 | 0.4 | HLA-DRB5 HLA-DRA | Type I diabetes mellitus |
| KEGG:05320 | 0.00352719256651 | 0.4 | HLA-DRB5 HLA-DRA | Autoimmune thyroid disease |
| KEGG:05321 | 0.00408172507551 | 0.4 | HLA-DRB5 HLA-DRA | Inflammatory bowel disease |
| REAC:R-HSA-202433 | 0.00418294558639 | 0.4 | HLA-DRB5 HLA-DRA | Generation of second messenger molecules |
| KEGG:05150 | 0.0057569162449 | 0.4 | HLA-DRB5 HLA-DRA | Staphylococcus aureus infection |
| KEGG:05416 | 0.00645863473927 | 0.4 | HLA-DRB5 HLA-DRA | Viral myocarditis |
| KEGG:04640 | 0.00771708586936 | 0.4 | HLA-DRB5 HLA-DRA | Hematopoietic cell lineage |
| KEGG:04612 | 0.00825154536734 | 0.4 | HLA-DRB5 HLA-DRA | Antigen processing and presentation |
| KEGG:05140 | 0.00852542753416 | 0.4 | HLA-DRB5 HLA-DRA | Leishmaniasis |
| KEGG:05323 | 0.0102617382696 | 0.4 | HLA-DRB5 HLA-DRA | Rheumatoid arthritis |
| KEGG:04658 | 0.012157220678 | 0.4 | HLA-DRB5 HLA-DRA | Th1 and Th2 cell differentiation |
| WP:WP2328 | 0.0128896073912 | 0.4 | HLA-DRB5 HLA-DRA | Allograft rejection |
| KEGG:04659 | 0.0179869923441 | 0.4 | HLA-DRB5 HLA-DRA | Th17 cell differentiation |
| KEGG:05145 | 0.0183886697314 | 0.4 | HLA-DRB5 HLA-DRA | Toxoplasmosis |
| KEGG:04514 | 0.024008315736 | 0.4 | HLA-DRB5 HLA-DRA | Cell adhesion molecules |
| REAC:R-HSA-388841 | 0.0240791876622 | 0.4 | HLA-DRB5 HLA-DRA | Costimulation by the CD28 family |
| KEGG:05322 | 0.0258857078716 | 0.4 | HLA-DRB5 HLA-DRA | Systemic lupus erythematosus |
| KEGG:04145 | 0.038606937256 | 0.4 | HLA-DRB5 HLA-DRA | Phagosome |
| WP:WP4217 | 0.0386238148414 | 0.4 | HLA-DRB5 HLA-DRA | Ebola virus infection in host |
| REAC:R-HSA-877300 | 0.0428866281036 | 0.4 | HLA-DRB5 HLA-DRA | Interferon gamma signaling |
| KEGG:05164 | 0.0458988724567 | 0.4 | HLA-DRB5 HLA-DRA | Influenza A |
| KEGG:05152 | 0.0471742362289 | 0.4 | HLA-DRB5 HLA-DRA | Tuberculosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HLA-DRA | HLA-DRB5 | 0.998 | 0.524 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GABRQ | HLA-DRA | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CHST9 | HLA-DRA | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GLCE | HLA-DRA | 0.968 | 0.048 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GLCE | GABRQ | 0.356 | bioplex3_WMM WMM_only | |
| GABRQ | HLA-DRB5 | 0.046 | bioplex3_WMM WMM_only | |
| GLCE | HLA-DRB5 | 0.042 | 0.064 | bioplex3_WMM WMM_only |
Related Complexes