hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06483.1
Complex Portal: CPX-11955
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | 5 | UniProt NCBI |
| RHOA | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | 5 | UniProt NCBI |
| MFSD11 | UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) | 4 | UniProt NCBI |
| XPNPEP1 | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-416572 | 0.00175047124894 | 0.5 | ARHGEF11 RHOA | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-400685 | 0.00258893271292 | 0.5 | ARHGEF11 RHOA | Sema4D in semaphorin signaling |
| KEGG:04928 | 0.00847251296121 | 0.5 | ARHGEF11 RHOA | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.0113396114984 | 0.5 | ARHGEF11 RHOA | Vascular smooth muscle contraction |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | ARHGEF11 RHOA | Semaphorin interactions |
| REAC:R-HSA-416482 | 0.019281632575 | 0.5 | ARHGEF11 RHOA | G alpha (12/13) signalling events |
| REAC:R-HSA-9013106 | 0.0212029570934 | 0.5 | ARHGEF11 RHOA | RHOC GTPase cycle |
| REAC:R-HSA-193704 | 0.0275106007785 | 0.5 | ARHGEF11 RHOA | p75 NTR receptor-mediated signalling |
| KEGG:05130 | 0.0334335704012 | 0.5 | ARHGEF11 RHOA | Pathogenic Escherichia coli infection |
| KEGG:05163 | 0.0451972531521 | 0.5 | ARHGEF11 RHOA | Human cytomegalovirus infection |
| CORUM:553 | 0.049938562206 | 0.25 | RHOA | RHOA-IP3R-TRPC1 complex |
| CORUM:816 | 0.049938562206 | 0.25 | RHOA | MRIP-RHOA complex |
| CORUM:3153 | 0.049938562206 | 0.25 | RHOA | GNAQ-GEFT-RHOA complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MFSD11 | RHOA | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| XPNPEP1 | RHOA | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARHGEF11 | RHOA | 0.973 |
mutually_exclusive (P08134)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPNPEP1 | ARHGEF11 | 0.217 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes