hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06494.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | 5 | UniProt NCBI |
| RGPD1 | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | 3 | UniProt NCBI |
| RAN | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | 5 | UniProt NCBI |
| DLGAP5 | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | 5 | UniProt NCBI |
| NUSAP1 | Nucleolar and spindle-associated protein 1 (NuSAP) | 5 | UniProt NCBI |
| B2M | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | 5 | UniProt NCBI |
| RGPD2 | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | 3 | UniProt NCBI |
| RCC1 | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | 5 | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| RANGAP1 | Ran GTPase-activating protein 1 (RanGAP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9615933 | 1.66051543107e-07 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-2995410 | 1.18372592435e-05 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | Nuclear Envelope (NE) Reassembly |
| KEGG:03013 | 1.33275465027e-05 | 0.444444444444 | UBE2I RANGAP1 RAN SUMO2 | Nucleocytoplasmic transport |
| REAC:R-HSA-162909 | 0.000147302456461 | 0.444444444444 | RCC1 RANGAP1 RAN B2M | Host Interactions of HIV factors |
| REAC:R-HSA-165054 | 0.000188109751173 | 0.333333333333 | RCC1 RAN RANGAP1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-177243 | 0.000226805410345 | 0.333333333333 | RCC1 RAN RANGAP1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-9793242 | 0.000239571230342 | 0.222222222222 | UBE2I RANGAP1 | SUMOylation of nuclear envelope proteins |
| REAC:R-HSA-4615885 | 0.000434042545956 | 0.333333333333 | UBE2I SUMO2 RANGAP1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-3065678 | 0.0011967088847 | 0.222222222222 | UBE2I SUMO2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-162906 | 0.00143161155991 | 0.444444444444 | RCC1 RANGAP1 RAN B2M | HIV Infection |
| REAC:R-HSA-68882 | 0.00148368678123 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0015102451773 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | Mitotic Metaphase and Anaphase |
| WP:WP4657 | 0.00231220241685 | 0.333333333333 | RCC1 RAN RANGAP1 | 22q11 2 copy number variation syndrome |
| REAC:R-HSA-3215018 | 0.00286935042585 | 0.222222222222 | UBE2I SUMO2 | Processing and activation of SUMO |
| REAC:R-HSA-196791 | 0.00358554253109 | 0.222222222222 | UBE2I SUMO2 | Vitamin D (calciferol) metabolism |
| GO:0140014 | 0.0050677296575 | 0.555555555556 | UBE2I RCC1 NUSAP1 RAN DLGAP5 | mitotic nuclear division |
| GO:0005643 | 0.00596183262373 | 0.444444444444 | UBE2I RANGAP1 RAN RGPD2 | nuclear pore |
| REAC:R-HSA-9824446 | 0.00644900522555 | 0.555555555556 | UBE2I RCC1 RANGAP1 RAN B2M | Viral Infection Pathways |
| HPA:0471411 | 0.00740976145381 | 0.555555555556 | RANGAP1 SUMO2 DLGAP5 B2M NUSAP1 | skin 2; cells in spinous layer[>=Low] |
| HPA:0461391 | 0.00808378338 | 0.555555555556 | RANGAP1 SUMO2 DLGAP5 B2M NUSAP1 | skin 1; cells in basal layer[>=Low] |
| REAC:R-HSA-3232118 | 0.00835291407054 | 0.222222222222 | UBE2I SUMO2 | SUMOylation of transcription factors |
| REAC:R-HSA-4090294 | 0.0108121024449 | 0.222222222222 | UBE2I SUMO2 | SUMOylation of intracellular receptors |
| REAC:R-HSA-8957322 | 0.0108901888715 | 0.333333333333 | UBE2I RAN SUMO2 | Metabolism of steroids |
| HPA:0471391 | 0.0120791720662 | 0.555555555556 | RANGAP1 SUMO2 DLGAP5 B2M NUSAP1 | skin 2; cells in basal layer[>=Low] |
| REAC:R-HSA-68886 | 0.0130073366317 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | M Phase |
| REAC:R-HSA-162599 | 0.0131636816219 | 0.333333333333 | RCC1 RAN RANGAP1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.0171260552969 | 0.333333333333 | RCC1 RAN RANGAP1 | HIV Life Cycle |
| REAC:R-HSA-5663205 | 0.0174507834687 | 0.555555555556 | UBE2I RCC1 RANGAP1 RAN B2M | Infectious disease |
| REAC:R-HSA-3108232 | 0.0235262214575 | 0.333333333333 | UBE2I SUMO2 RANGAP1 | SUMO E3 ligases SUMOylate target proteins |
| HPA:0030432 | 0.0240411721099 | 0.333333333333 | DLGAP5 B2M NUSAP1 | appendix; germinal center cells[>=Medium] |
| HPA:0461413 | 0.0247731600554 | 0.333333333333 | RANGAP1 NUSAP1 SUMO2 | skin 1; cells in spinous layer[High] |
| REAC:R-HSA-2990846 | 0.0258063693812 | 0.333333333333 | UBE2I SUMO2 RANGAP1 | SUMOylation |
| GO:0000280 | 0.0264467978108 | 0.555555555556 | UBE2I RCC1 NUSAP1 RAN DLGAP5 | nuclear division |
| HPA:0460202 | 0.0296661231022 | 0.444444444444 | RANGAP1 SUMO2 DLGAP5 B2M | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.0298703924638 | 0.444444444444 | RANGAP1 SUMO2 NUSAP1 B2M | skin 1; cells in spinous layer[>=Medium] |
| WP:WP5362 | 0.0356319901131 | 0.222222222222 | UBE2I SUMO2 | TAR syndrome |
| REAC:R-HSA-180746 | 0.0368028731299 | 0.222222222222 | RCC1 RAN | Nuclear import of Rev protein |
| HPA:0030442 | 0.0385283795644 | 0.333333333333 | DLGAP5 B2M NUSAP1 | appendix; non-germinal center cells[>=Medium] |
| REAC:R-HSA-4085377 | 0.0392438573551 | 0.222222222222 | UBE2I SUMO2 | SUMOylation of SUMOylation proteins |
| HPA:0471413 | 0.0420791600644 | 0.333333333333 | RANGAP1 NUSAP1 SUMO2 | skin 2; cells in spinous layer[High] |
| REAC:R-HSA-69278 | 0.0428747976055 | 0.444444444444 | UBE2I RANGAP1 RAN RCC1 | Cell Cycle, Mitotic |
| HPA:0310432 | 0.0460528081793 | 0.777777777778 | RCC1 SUMO2 UBE2I B2M NUSAP1 RANGAP1 DLGAP5 | lymph node; germinal center cells[>=Medium] |
| GO:0048285 | 0.0471451748895 | 0.555555555556 | UBE2I RCC1 NUSAP1 RAN DLGAP5 | organelle fission |
| HPA:0030431 | 0.048077197281 | 0.333333333333 | DLGAP5 B2M NUSAP1 | appendix; germinal center cells[>=Low] |
| GO:1902850 | 0.0489603106588 | 0.444444444444 | RCC1 NUSAP1 RAN DLGAP5 | microtubule cytoskeleton organization involved in mitosis |
| HPA:0471412 | 0.0498011129854 | 0.444444444444 | RANGAP1 SUMO2 NUSAP1 B2M | skin 2; cells in spinous layer[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAN | RANGAP1 | 1.0 | 0.242 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| UBE2I | RCC1 | 1.0 | 0.07 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| UBE2I | RANGAP1 | 1.0 | 0.202 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| RCC1 | RANGAP1 | 1.0 | 0.254 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| RAN | RCC1 | 1.0 | 0.16 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM |
| SUMO2 | UBE2I | 0.999 | 0.436 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| RAN | DLGAP5 | 0.999 | 0.213514285714 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SUMO2 | RCC1 | 0.999 | 0.161 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| NUSAP1 | RCC1 | 0.998 | 0.212 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| RGPD1 | RAN | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DLGAP5 | RCC1 | 0.995 | 0.096 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| RAN | RGPD2 | 0.995 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAN | NUSAP1 | 0.995 | 0.282 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RGPD1 | RCC1 | 0.995 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| RAN | UBE2I | 0.994 | 0.45 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM |
| B2M | RANGAP1 | 0.991 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| RAN | B2M | 0.99 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| RGPD2 | RANGAP1 | 0.99 | 0.184 | bioplex_WMM Guru bioplex3_WMM fraction |
| SUMO2 | RAN | 0.98 | 0.49 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| B2M | RCC1 | 0.976 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| B2M | UBE2I | 0.965 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NUSAP1 | RANGAP1 | 0.96 | 0.254 | hein_WMM bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| RGPD2 | UBE2I | 0.955 | 0.118 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RGPD2 | RCC1 | 0.955 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| RGPD1 | NUSAP1 | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RGPD1 | RANGAP1 | 0.948 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only | |
| DLGAP5 | RANGAP1 | 0.945 | 0.154 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| B2M | RGPD2 | 0.916 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RGPD1 | UBE2I | 0.906 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SUMO2 | RANGAP1 | 0.851 | 0.45 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| DLGAP5 | UBE2I | 0.837 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| NUSAP1 | UBE2I | 0.761 | 0.164 | hein_WMM bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| DLGAP5 | NUSAP1 | 0.749 | 0.168 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| DLGAP5 | B2M | 0.486 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| NUSAP1 | B2M | 0.375 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RGPD1 | DLGAP5 | 0.329 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DLGAP5 | RGPD2 | 0.227 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| NUSAP1 | RGPD2 | 0.202 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| SUMO2 | RGPD2 | 0.114 | 0.1645 | bioplex3_WMM WMM_only |
| SUMO2 | NUSAP1 | 0.099 | 0.3 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| RGPD1 | RGPD2 | 0.055 | bioplex3_WMM WMM_only | |
| SUMO2 | DLGAP5 | 0.013 | 0.244 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SUMO2 | RGPD1 | 0.007 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SUMO2 | B2M | 0.004 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes