hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06496.1
Complex Portal: CPX-19672
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SGSM2 | Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1) | 5 | UniProt NCBI |
| MICAL2 | [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) | 5 | UniProt NCBI |
| PLA2G7 | Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) | 5 | UniProt NCBI |
| BPNT2 | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase) | 5 | UniProt NCBI |
| PTPRN | Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] | 5 | UniProt NCBI |
| PTPRN2 | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0020063 | 0.00145389004938 | 0.333333333333 | PTPRN PTPRN2 | adrenal gland; medullary cells[High] |
| HPA:0020062 | 0.0034980693017 | 0.333333333333 | PTPRN PTPRN2 | adrenal gland; medullary cells[>=Medium] |
| HPA:0020061 | 0.00381537880503 | 0.333333333333 | PTPRN PTPRN2 | adrenal gland; medullary cells[>=Low] |
| KEGG:04940 | 0.00429978170568 | 0.333333333333 | PTPRN PTPRN2 | Type I diabetes mellitus |
| HPA:0370493 | 0.00560735489577 | 0.333333333333 | PTPRN PTPRN2 | pituitary gland; cells in anterior [High] |
| HPA:0370492 | 0.00969333822175 | 0.333333333333 | PTPRN PTPRN2 | pituitary gland; cells in anterior [>=Medium] |
| HPA:0370000 | 0.0102154360236 | 0.333333333333 | PTPRN PTPRN2 | pituitary gland |
| HPA:0370491 | 0.0102154360236 | 0.333333333333 | PTPRN PTPRN2 | pituitary gland; cells in anterior [>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SGSM2 | PTPRN | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MICAL2 | PTPRN | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PTPRN | PTPRN2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| BPNT2 | PTPRN | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PLA2G7 | PTPRN | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SGSM2 | PTPRN2 | 0.938 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MICAL2 | SGSM2 | 0.868 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BPNT2 | MICAL2 | 0.693 | bioplex3_WMM WMM_only | ||
| MICAL2 | PTPRN2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BPNT2 | SGSM2 | 0.444 | bioplex3_WMM WMM_only | ||
| BPNT2 | PTPRN2 | 0.051 | bioplex3_WMM WMM_only |
Related Complexes