hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06505.1
Complex Portal: CPX-25629
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHCHD3 | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | 5 | UniProt NCBI |
| SGPP1 | Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) | 5 | UniProt NCBI |
| ABCD3 | ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) | 5 | UniProt NCBI |
| MCU | Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A) | 5 | UniProt NCBI |
| SARAF | Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66) | 5 | UniProt NCBI |
| DNAJC11 | DnaJ homolog subfamily C member 11 | 5 | UniProt NCBI |
| ERLIN2 | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | 5 | UniProt NCBI |
| MGST3 | Glutathione S-transferase 3, mitochondrial (GST-3) (EC 2.5.1.-) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20) | 5 | UniProt NCBI |
| SLC25A24 | Mitochondrial adenyl nucleotide antiporter SLC25A24 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Short calcium-binding mitochondrial carrier protein 1) (SCaMC-1) (Solute carrier family 25 member 24) | 5 | UniProt NCBI |
| RNF185 | E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185) | 5 | UniProt NCBI |
| DHRS7B | Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 0.00138006084651 | 0.2 | CHCHD3 DNAJC11 | MIB complex |
| REAC:R-HSA-8949613 | 0.04382523057 | 0.2 | CHCHD3 DNAJC11 | Cristae formation |
| GO:0031090 | 0.0481586078992 | 0.9 | MGST3 DHRS7B DNAJC11 SGPP1 ERLIN2 CHCHD3 SARAF MCU RNF185 | organelle membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ABCD3 | MGST3 | 0.996 | 0.128 | |
| RNF185 | ERLIN2 | 0.996 | 0.144 | |
| RNF185 | DHRS7B | 0.994 | 0.162 | |
| SGPP1 | DHRS7B | 0.992 | 0.056 | |
| CHCHD3 | DNAJC11 | 0.992 | 0.662 | |
| MCU | DHRS7B | 0.991 | 0.05 | |
| RNF185 | ABCD3 | 0.99 | 0.146 | |
| ABCD3 | SLC25A24 | 0.99 | 0.174 | |
| SGPP1 | ABCD3 | 0.989 | 0.052 | |
| ABCD3 | MCU | 0.988 | 0.214 | |
| SGPP1 | DNAJC11 | 0.988 | 0.12 | |
| DNAJC11 | DHRS7B | 0.987 | 0.046 | |
| CHCHD3 | ABCD3 | 0.987 | 0.162 | |
| DNAJC11 | MGST3 | 0.985 | 0.066 | |
| ABCD3 | DHRS7B | 0.985 | 0.054 | |
| SARAF | ERLIN2 | 0.983 | 0.17 | |
| SARAF | SGPP1 | 0.981 | 0.15 |
mutually_exclusive (Q9Y3E0)
|
| MCU | DNAJC11 | 0.98 | 0.23 | |
| RNF185 | SARAF | 0.98 | 0.072 | |
| ABCD3 | DNAJC11 | 0.979 | 0.144 | |
| SARAF | DNAJC11 | 0.977 | 0.094 | |
| MGST3 | DHRS7B | 0.967 | 0.094 | |
| CHCHD3 | DHRS7B | 0.966 | 0.088 | |
| ABCD3 | ERLIN2 | 0.961 | 0.236 | |
| SARAF | ABCD3 | 0.96 | 0.154 | |
| CHCHD3 | MGST3 | 0.959 | 0.104 | |
| SGPP1 | MGST3 | 0.955 | 0.082 | |
| RNF185 | MCU | 0.95 | 0.122 | |
| MCU | MGST3 | 0.939 | 0.062 | |
| MCU | ERLIN2 | 0.916 | 0.136 | |
| CHCHD3 | MCU | 0.903 | 0.312 | |
| SGPP1 | MCU | 0.894 | 0.06 | |
| RNF185 | DNAJC11 | 0.887 | 0.088 | |
| CHCHD3 | ERLIN2 | 0.875 | 0.176 | |
| RNF185 | MGST3 | 0.855 | 0.11 | |
| RNF185 | SGPP1 | 0.854 | 0.184 | |
| MCU | SLC25A24 | 0.696 | 0.128 | |
| SARAF | DHRS7B | 0.689 | 0.076 | |
| SARAF | MGST3 | 0.638 | 0.078 |
mutually_exclusive (Q9Y3E0)
|
| RNF185 | CHCHD3 | 0.618 | 0.14 | |
| SGPP1 | ERLIN2 | 0.604 | 0.106 | |
| CHCHD3 | SGPP1 | 0.583 | 0.154 | |
| MGST3 | SLC25A24 | 0.582 | 0.128 | |
| DNAJC11 | ERLIN2 | 0.52 | 0.114 | |
| SLC25A24 | DHRS7B | 0.482 | 0.02 | |
| ERLIN2 | MGST3 | 0.436 | 0.176 | |
| CHCHD3 | SLC25A24 | 0.434 | 0.32 | |
| ERLIN2 | DHRS7B | 0.177 | 0.094 | |
| DNAJC11 | SLC25A24 | 0.142 | 0.074 | |
| SARAF | SLC25A24 | 0.127 | 0.126 | |
| SARAF | CHCHD3 | 0.092 | 0.116 | |
| SGPP1 | SLC25A24 | 0.059 | 0.07 | |
| RNF185 | SLC25A24 | 0.054 | 0.072 | |
| SARAF | MCU | 0.02 | 0.096 | |
| ERLIN2 | SLC25A24 | 0.017 | 0.074 |
Related Complexes