hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06517.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP43 | Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) | 5 | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 5 | UniProt NCBI |
| NUP160 | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:87 | 1.96449718988e-08 | 1.0 | NUP98 NUP43 NUP160 | Nup 107-160 subcomplex |
| WP:WP3998 | 7.12226249528e-06 | 1.0 | NUP98 NUP43 NUP160 | Prader Willi and Angelman syndrome |
| KEGG:03013 | 8.70565480728e-06 | 1.0 | NUP98 NUP43 NUP160 | Nucleocytoplasmic transport |
| GO:0031080 | 1.15344049292e-05 | 1.0 | NUP98 NUP43 NUP160 | nuclear pore outer ring |
| CORUM:1347 | 2.05032700758e-05 | 0.666666666667 | NUP98 NUP160 | NPC subcomplex (NUP98, NUP107, NUP133, NUP160) |
| KEGG:05014 | 0.00029339200738 | 1.0 | NUP98 NUP43 NUP160 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-9615933 | 0.00188000535098 | 0.666666666667 | NUP160 NUP43 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-170822 | 0.00257431960226 | 0.666666666667 | NUP160 NUP43 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 0.00257431960226 | 0.666666666667 | NUP160 NUP43 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168271 | 0.00276488364952 | 0.666666666667 | NUP160 NUP43 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 0.00276488364952 | 0.666666666667 | NUP160 NUP43 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168333 | 0.00276488364952 | 0.666666666667 | NUP160 NUP43 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-180910 | 0.00316638779295 | 0.666666666667 | NUP160 NUP43 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 0.00316638779295 | 0.666666666667 | NUP160 NUP43 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 0.00316638779295 | 0.666666666667 | NUP160 NUP43 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.0033773260227 | 0.666666666667 | NUP160 NUP43 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 0.0033773260227 | 0.666666666667 | NUP160 NUP43 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 0.0033773260227 | 0.666666666667 | NUP160 NUP43 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 0.00359505378021 | 0.666666666667 | NUP160 NUP43 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 0.00381957013228 | 0.666666666667 | NUP160 NUP43 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 0.00381957013228 | 0.666666666667 | NUP160 NUP43 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 0.00405087414568 | 0.666666666667 | NUP160 NUP43 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.00453384142373 | 0.666666666667 | NUP160 NUP43 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.00478550282195 | 0.666666666667 | NUP160 NUP43 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.00504394814871 | 0.666666666667 | NUP160 NUP43 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.00530917647079 | 0.666666666667 | NUP160 NUP43 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.00585997836812 | 0.666666666667 | NUP160 NUP43 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.00614555007695 | 0.666666666667 | NUP160 NUP43 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.00735562020533 | 0.666666666667 | NUP160 NUP43 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.00867409880878 | 0.666666666667 | NUP160 NUP43 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.00867409880878 | 0.666666666667 | NUP160 NUP43 | Metabolism of non-coding RNA |
| GO:0005643 | 0.00883160549414 | 1.0 | NUP98 NUP43 NUP160 | nuclear pore |
| REAC:R-HSA-6784531 | 0.0101009261622 | 0.666666666667 | NUP160 NUP43 | tRNA processing in the nucleus |
| REAC:R-HSA-3371453 | 0.0141416283812 | 0.666666666667 | NUP160 NUP43 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0141416283812 | 0.666666666667 | NUP160 NUP43 | Glycolysis |
| REAC:R-HSA-1169408 | 0.0145828870271 | 0.666666666667 | NUP160 NUP43 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 0.0145828870271 | 0.666666666667 | NUP160 NUP43 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-2995410 | 0.0150309034717 | 0.666666666667 | NUP160 NUP43 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-159236 | 0.0164154902665 | 0.666666666667 | NUP160 NUP43 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-5619102 | 0.0164154902665 | 0.666666666667 | NUP160 NUP43 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.0168905285744 | 0.666666666667 | NUP160 NUP43 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.017372320015 | 0.666666666667 | NUP160 NUP43 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.0209338694285 | 0.666666666667 | NUP160 NUP43 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-70326 | 0.0209338694285 | 0.666666666667 | NUP160 NUP43 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.0242497192193 | 0.666666666667 | NUP160 NUP43 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.0278082114556 | 0.666666666667 | NUP160 NUP43 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-141444 | 0.0284248695791 | 0.666666666667 | NUP160 NUP43 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0284248695791 | 0.666666666667 | NUP160 NUP43 | Amplification of signal from the kinetochores |
| REAC:R-HSA-72306 | 0.0329299631783 | 0.666666666667 | NUP160 NUP43 | tRNA processing |
| REAC:R-HSA-9610379 | 0.0329299631783 | 0.666666666667 | NUP160 NUP43 | HCMV Late Events |
| REAC:R-HSA-69618 | 0.0392065258044 | 0.666666666667 | NUP160 NUP43 | Mitotic Spindle Checkpoint |
| GO:0000776 | 0.0402954436201 | 1.0 | NUP98 NUP43 NUP160 | kinetochore |
| REAC:R-HSA-9705671 | 0.0421708333427 | 0.666666666667 | NUP160 NUP43 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-9648025 | 0.0429286997388 | 0.666666666667 | NUP160 NUP43 | EML4 and NUDC in mitotic spindle formation |
| GO:0000779 | 0.0439566559847 | 1.0 | NUP98 NUP43 NUP160 | condensed chromosome, centromeric region |
| REAC:R-HSA-211000 | 0.0468187221283 | 0.666666666667 | NUP160 NUP43 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.0484217025219 | 0.666666666667 | NUP160 NUP43 | HCMV Early Events |
| REAC:R-HSA-2500257 | 0.049233254294 | 0.666666666667 | NUP160 NUP43 | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUP98 | NUP43 | 0.999 | 0.84 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| NUP160 | NUP43 | 0.999 | 0.83 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP98 | NUP160 | 0.971 | 0.888 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM |
Related Complexes