hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06520.1
Complex Portal: CPX-17948
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNRF2 | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | 5 | UniProt NCBI |
| TMEM266 | Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1) | 5 | UniProt NCBI |
| RPIA | Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) | 5 | UniProt NCBI |
| WDR5B | WD repeat-containing protein 5B | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5659996 | 0.0499436884912 | 0.25 | RPIA | RPIA deficiency: failed conversion of R5P to RU5P |
| REAC:R-HSA-6791461 | 0.0499436884912 | 0.25 | RPIA | RPIA deficiency: failed conversion of RU5P to R5P |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPIA | WDR5B | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR5B | ZNRF2 | 0.994 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR5B | TMEM266 | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RPIA | ZNRF2 | 0.504 | 0.014 |
mutually_exclusive (Q86VZ2)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ZNRF2 | TMEM266 | 0.192 | bioplex3_WMM WMM_only | ||
| RPIA | TMEM266 | 0.175 | bioplex3_WMM WMM_only |
Related Complexes