hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06528.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC5 | Origin recognition complex subunit 5 | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000808 | 1.84188417064e-09 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | origin recognition complex |
| GO:0005664 | 1.84188417064e-09 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | nuclear origin of replication recognition complex |
| CORUM:1034 | 2.80628050973e-09 | 0.75 | ORC2 ORC3 ORC5 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 7.01534115619e-09 | 0.75 | ORC2 ORC3 ORC5 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1033 | 1.40299620761e-08 | 0.75 | ORC2 ORC3 ORC5 | ORC complex (origin recognition complex) |
| CORUM:1031 | 1.40299620761e-08 | 0.75 | ORC2 ORC3 ORC5 | ORC complex (origin recognition complex) |
| CORUM:389 | 1.40299620761e-08 | 0.75 | ORC2 ORC3 ORC5 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 7.85597209803e-08 | 0.75 | ORC2 ORC3 ORC5 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 1.17833531486e-07 | 0.75 | ORC2 ORC3 ORC5 | E2F-enabled inhibition of pre-replication complex formation |
| GO:0006270 | 9.46202211089e-07 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | DNA replication initiation |
| REAC:R-HSA-113510 | 2.1588394976e-06 | 0.75 | ORC2 ORC3 ORC5 | E2F mediated regulation of DNA replication |
| WP:WP466 | 4.00454251624e-06 | 0.75 | ORC2 ORC3 ORC5 | DNA replication |
| REAC:R-HSA-68962 | 7.64413736449e-06 | 0.75 | ORC2 ORC3 ORC5 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 1.00019654619e-05 | 0.75 | ORC2 ORC3 ORC5 | Activation of ATR in response to replication stress |
| WP:WP45 | 1.4517114839e-05 | 0.75 | ORC2 ORC3 ORC5 | G1 to S cell cycle control |
| CORUM:1032 | 1.53774525569e-05 | 0.5 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| CORUM:5251 | 3.07520988333e-05 | 0.5 | ORC2 ORC3 | Ku-ORC complex |
| REAC:R-HSA-68616 | 4.09441910601e-05 | 0.75 | ORC2 ORC3 ORC5 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-68949 | 7.65476877178e-05 | 0.75 | ORC2 ORC3 ORC5 | Orc1 removal from chromatin |
| GO:0003688 | 8.45465618902e-05 | 0.75 | ORC2 ORC3 ORC5 | DNA replication origin binding |
| WP:WP179 | 8.8077388901e-05 | 0.75 | ORC2 ORC3 ORC5 | Cell cycle |
| REAC:R-HSA-69052 | 0.000164113242291 | 0.75 | ORC2 ORC3 ORC5 | Switching of origins to a post-replicative state |
| KEGG:04110 | 0.000191622909408 | 0.75 | ORC2 ORC3 ORC5 | Cell cycle |
| REAC:R-HSA-69239 | 0.000381938496194 | 0.75 | ORC2 ORC3 ORC5 | Synthesis of DNA |
| GO:0006261 | 0.000415139510394 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | DNA-templated DNA replication |
| GO:0000781 | 0.000464844728187 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | chromosome, telomeric region |
| REAC:R-HSA-69206 | 0.000498740793897 | 0.75 | ORC2 ORC3 ORC5 | G1/S Transition |
| REAC:R-HSA-68867 | 0.000498740793897 | 0.75 | ORC2 ORC3 ORC5 | Assembly of the pre-replicative complex |
| REAC:R-HSA-453279 | 0.000722417813202 | 0.75 | ORC2 ORC3 ORC5 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69002 | 0.000722417813202 | 0.75 | ORC2 ORC3 ORC5 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69242 | 0.000915028341188 | 0.75 | ORC2 ORC3 ORC5 | S Phase |
| REAC:R-HSA-69481 | 0.000915028341188 | 0.75 | ORC2 ORC3 ORC5 | G2/M Checkpoints |
| GO:0000228 | 0.000948358662764 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | nuclear chromosome |
| REAC:R-HSA-69306 | 0.00120023774581 | 0.75 | ORC2 ORC3 ORC5 | DNA Replication |
| GO:0006260 | 0.00227782697336 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | DNA replication |
| REAC:R-HSA-69620 | 0.00495341247057 | 0.75 | ORC2 ORC3 ORC5 | Cell Cycle Checkpoints |
| GO:0098687 | 0.0111408206209 | 1.0 | ORC5 ORC2 ORC3 LRWD1 | chromosomal region |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | ORC2 ORC3 ORC5 | Cell Cycle, Mitotic |
| CORUM:2205 | 0.049938562206 | 0.25 | ORC5 | ORC5-ORC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| ORC2 | ORC5 | 0.994 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| LRWD1 | ORC5 | 0.991 | 0.672 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| LRWD1 | ORC3 | 0.858 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ORC3 | ORC5 | 0.692 | youn_WMM gupta_WMM fraction treiber_WMM |
Related Complexes