hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06531.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 5 | UniProt NCBI |
| JMY | Junction-mediating and -regulatory protein | 5 | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | 5 | UniProt NCBI |
| MYL3 | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | 5 | UniProt NCBI |
| IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | 5 | UniProt NCBI |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-195258 | 0.000440361429128 | 0.666666666667 | IQGAP1 IQGAP2 MYL6 MYL12B | RHO GTPase Effectors |
| KEGG:04814 | 0.00135053284488 | 0.5 | MYL3 MYL6 MYL12B | Motor proteins |
| KEGG:04810 | 0.00235078889433 | 0.5 | IQGAP1 MYL12B IQGAP2 | Regulation of actin cytoskeleton |
| GO:0015629 | 0.00322461566408 | 0.833333333333 | IQGAP1 MYL3 IQGAP2 MYL6 MYL12B | actin cytoskeleton |
| REAC:R-HSA-397014 | 0.00380890170895 | 0.5 | MYL3 MYL6 MYL12B | Muscle contraction |
| WP:WP4352 | 0.00400681842466 | 0.5 | IQGAP1 MYL6 IQGAP2 | Ciliary landscape |
| REAC:R-HSA-416572 | 0.00440152140132 | 0.333333333333 | MYL6 MYL12B | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627117 | 0.00440152140132 | 0.333333333333 | MYL6 MYL12B | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00440152140132 | 0.333333333333 | MYL6 MYL12B | RHO GTPases activate CIT |
| REAC:R-HSA-5627123 | 0.00488968644054 | 0.333333333333 | MYL6 MYL12B | RHO GTPases activate PAKs |
| WP:WP524 | 0.00529013036744 | 0.333333333333 | IQGAP1 IQGAP2 | G13 signaling pathway |
| REAC:R-HSA-400685 | 0.00650743774508 | 0.333333333333 | MYL6 MYL12B | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 0.00835477835936 | 0.333333333333 | MYL6 MYL12B | EPHA-mediated growth cone collapse |
| REAC:R-HSA-194315 | 0.0087987737143 | 0.666666666667 | IQGAP1 IQGAP2 MYL6 MYL12B | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00959411672385 | 0.666666666667 | IQGAP1 IQGAP2 MYL6 MYL12B | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-5626467 | 0.0104313293282 | 0.333333333333 | IQGAP1 IQGAP2 | RHO GTPases activate IQGAPs |
| REAC:R-HSA-445355 | 0.0170865043842 | 0.333333333333 | MYL6 MYL12B | Smooth Muscle Contraction |
| GO:2000689 | 0.0210651876021 | 0.333333333333 | IQGAP1 IQGAP2 | actomyosin contractile ring assembly actin filament organization |
| GO:1903479 | 0.0210651876021 | 0.333333333333 | IQGAP1 IQGAP2 | mitotic actomyosin contractile ring assembly actin filament organization |
| GO:1903475 | 0.0210651876021 | 0.333333333333 | IQGAP1 IQGAP2 | mitotic actomyosin contractile ring assembly |
| GO:1902407 | 0.0210651876021 | 0.333333333333 | IQGAP1 IQGAP2 | assembly of actomyosin apparatus involved in mitotic cytokinesis |
| KEGG:04520 | 0.0261678409889 | 0.333333333333 | IQGAP1 MYL12B | Adherens junction |
| REAC:R-HSA-373755 | 0.0437202891307 | 0.333333333333 | MYL6 MYL12B | Semaphorin interactions |
| CORUM:1844 | 0.0499436884912 | 0.166666666667 | IQGAP1 | APC-IQGAP1 complex |
| CORUM:6729 | 0.0499436884912 | 0.166666666667 | IQGAP1 | IQGAP1-CXCR2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IQGAP2 | MYL6 | 0.995 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| MYL6 | MYL12B | 0.993 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| MYL3 | IQGAP1 | 0.992 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MYL6 | IQGAP1 | 0.991 | 0.252624 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MYL12B | IQGAP1 | 0.984 | 0.544 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| JMY | MYL12B | 0.979 | 0.042 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| JMY | MYL6 | 0.979 | 0.058 | hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM fraction |
| MYL6 | MYL3 | 0.975 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MYL12B | MYL3 | 0.869 | 0.676 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IQGAP2 | MYL12B | 0.806 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| IQGAP2 | IQGAP1 | 0.503 | 0.262 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| JMY | IQGAP1 | 0.063 | 0.212 | hein_WMM WMM_only |
| IQGAP2 | MYL3 | 0.008 | 0.106 | bioplex3_HEK293 bioplex () |
Related Complexes