hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06533.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OCC1 | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | 2 | UniProt NCBI |
| VPS37C | Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) | 5 | UniProt NCBI |
| RAET1L | UL16-binding protein 6 (Retinoic acid early transcript 1L protein) | 5 | UniProt NCBI |
| VPS28 | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | 5 | UniProt NCBI |
| HRAS | GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] | 5 | UniProt NCBI |
| ZDHHC23 | Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) | 5 | UniProt NCBI |
| EFR3A | Protein EFR3 homolog A (Protein EFR3-like) | 5 | UniProt NCBI |
| ERICH5 | Glutamate-rich protein 5 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1192 | 7.17483486175e-05 | 0.25 | VPS37C VPS28 | ESCRT-I complex |
| REAC:R-HSA-174490 | 0.00505983974502 | 0.25 | VPS37C VPS28 | Membrane binding and targetting of GAG proteins |
| REAC:R-HSA-174495 | 0.00505983974502 | 0.25 | VPS37C VPS28 | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| REAC:R-HSA-175474 | 0.00666866305696 | 0.25 | VPS37C VPS28 | Assembly Of The HIV Virion |
| KEGG:04144 | 0.0101901500628 | 0.375 | HRAS VPS37C VPS28 | Endocytosis |
| REAC:R-HSA-162588 | 0.0194471683576 | 0.25 | VPS37C VPS28 | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 0.0240813966337 | 0.25 | VPS37C VPS28 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-9615710 | 0.0274432906045 | 0.25 | VPS37C VPS28 | Late endosomal microautophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS28 | VPS37C | 0.999 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZDHHC23 | ERICH5 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAET1L | ZDHHC23 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OCC1 | ZDHHC23 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZDHHC23 | EFR3A | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZDHHC23 | VPS37C | 0.967 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZDHHC23 | VPS28 | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HRAS | ZDHHC23 | 0.953 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ERICH5 | VPS37C | 0.952 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| HRAS | VPS37C | 0.923 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only |
| OCC1 | VPS37C | 0.921 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
| OCC1 | HRAS | 0.919 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
| OCC1 | ERICH5 | 0.812 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| EFR3A | ERICH5 | 0.799 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| ERICH5 | VPS28 | 0.776 | 0.03 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| HRAS | EFR3A | 0.739 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only |
| RAET1L | OCC1 | 0.652 | bioplex3_WMM WMM_only | |
| RAET1L | ERICH5 | 0.651 | bioplex3_WMM WMM_only | |
| OCC1 | VPS28 | 0.619 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| HRAS | VPS28 | 0.615 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| OCC1 | EFR3A | 0.545 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| HRAS | ERICH5 | 0.484 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| RAET1L | VPS28 | 0.335 | bioplex3_WMM WMM_only | |
| RAET1L | VPS37C | 0.251 | bioplex3_WMM WMM_only | |
| RAET1L | EFR3A | 0.251 | bioplex3_WMM WMM_only | |
| EFR3A | VPS37C | 0.172 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
| RAET1L | HRAS | 0.167 | bioplex3_WMM WMM_only | |
| EFR3A | VPS28 | 0.057 | 0.034 | bioplex3_WMM WMM_only |
Related Complexes