hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06536.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC13 | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | 5 | UniProt NCBI |
| SEC16B | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| SEC31A | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | 5 | UniProt NCBI |
| SCYL1 | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204005 | 0.000111649199751 | 0.6 | SEC31A SEC13 SEC16B | COPII-mediated vesicle transport |
| REAC:R-HSA-199977 | 0.0014678873081 | 0.6 | SEC31A SEC13 SEC16B | ER to Golgi Anterograde Transport |
| GO:0030662 | 0.00243730532859 | 0.8 | SEC31A SCYL1 SEC13 SEC16B | coated vesicle membrane |
| REAC:R-HSA-948021 | 0.00255576037195 | 0.6 | SEC31A SEC13 SEC16B | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-983170 | 0.00531742996423 | 0.4 | SEC31A SEC13 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-446203 | 0.0113314618617 | 0.6 | SEC31A SEC13 SEC16B | Asparagine N-linked glycosylation |
| GO:0030135 | 0.0130363720333 | 0.8 | SEC31A SCYL1 SEC13 SEC16B | coated vesicle |
| WP:WP1982 | 0.0132783799217 | 0.4 | SEC31A SEC13 | Sterol regulatory element binding proteins SREBP signaling |
| GO:0012507 | 0.016548216138 | 0.6 | SEC31A SEC13 SEC16B | ER to Golgi transport vesicle membrane |
| REAC:R-HSA-9639288 | 0.0208015819243 | 0.4 | SEC13 SESN2 | Amino acids regulate mTORC1 |
| GO:0030120 | 0.0279690439474 | 0.6 | SEC31A SEC13 SCYL1 | vesicle coat |
| GO:0048193 | 0.0280745884658 | 0.8 | SEC31A SCYL1 SEC13 SEC16B | Golgi vesicle transport |
| KEGG:04150 | 0.0484667159694 | 0.4 | SEC13 SESN2 | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC31A | SEC13 | 1.0 | 0.29 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SCYL1 | SEC31A | 0.998 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| SEC16B | SEC13 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SEC13 | SESN2 | 0.995 | 0.334 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SCYL1 | SEC13 | 0.968 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SEC31A | SESN2 | 0.96 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes