hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06552.1
Complex Portal: CPX-23285
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IER5L | Immediate early response gene 5-like protein | 2 | UniProt NCBI |
| CDCA4 | Cell division cycle-associated protein 4 (Hematopoietic progenitor protein) | 5 | UniProt NCBI |
| RAB11FIP5 | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | 5 | UniProt NCBI |
| FBXL16 | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | 4 | UniProt NCBI |
| IGFBP5 | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | 5 | UniProt NCBI |
| PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | 5 | UniProt NCBI |
| PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | 4 | UniProt NCBI |
| FOXS1 | Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10) | 4 | UniProt NCBI |
| SERTAD1 | SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) | 5 | UniProt NCBI |
| PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05142 | 0.00123626686132 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Chagas disease |
| KEGG:03015 | 0.00136715049003 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | mRNA surveillance pathway |
| KEGG:04071 | 0.00198163198395 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Sphingolipid signaling pathway |
| KEGG:04660 | 0.00198163198395 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | T cell receptor signaling pathway |
| KEGG:04728 | 0.00234724766639 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Dopaminergic synapse |
| KEGG:04152 | 0.00261407475108 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | AMPK signaling pathway |
| KEGG:04261 | 0.00305051913616 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Adrenergic signaling in cardiomyocytes |
| KEGG:05160 | 0.00406147233016 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Hepatitis C |
| KEGG:04530 | 0.00484440033129 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Tight junction |
| KEGG:04390 | 0.00560546698078 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Hippo signaling pathway |
| GO:0000159 | 0.00936146543831 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | protein phosphatase type 2A complex |
| WP:WP500 | 0.0272713027679 | 0.2 | PPP2R2B PPP2R2A | Glycogen synthesis and degradation |
| KEGG:04151 | 0.0404637839965 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.0438405134702 | 0.3 | PPP2R2B PPP2R2D PPP2R2A | Human papillomavirus infection |
| CORUM:5107 | 0.0499436884912 | 0.1 | SERTAD1 | p34(SEI-1)-CDK4-CyclinD2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PPP2R2D | PPP2R2A | 1.0 | 0.754 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| CDCA4 | PPP2R2A | 0.999 | 0.068 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| FBXL16 | IGFBP5 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CDCA4 | PPP2R2B | 0.997 | 0.0600670391061 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB11FIP5 | PPP2R2D | 0.996 | 0.012 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDCA4 | PPP2R2D | 0.995 | 0.056 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXL16 | PPP2R2B | 0.994 |
mutually_exclusive (P67775)
structurally_consistent (dimer) |
hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP2R2D | FOXS1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FBXL16 | PPP2R2D | 0.987 | hein_WMM bioplex3_WMM hein () | ||
| FOXS1 | PPP2R2A | 0.987 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB11FIP5 | PPP2R2A | 0.984 | 0.15 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| IGFBP5 | PPP2R2A | 0.982 | 0.07 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IER5L | PPP2R2B | 0.982 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IER5L | PPP2R2D | 0.98 |
mutually_exclusive (Q00005)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP2R2B | PPP2R2D | 0.976 | 0.922 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PPP2R2D | SERTAD1 | 0.972 |
mutually_exclusive (P67775)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB11FIP5 | PPP2R2B | 0.961 | 0.06 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only |
| PPP2R2B | PPP2R2A | 0.961 | 0.904 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| FBXL16 | CDCA4 | 0.959 | hein_WMM bioplex3_WMM WMM_only | ||
| SERTAD1 | PPP2R2A | 0.957 |
mutually_exclusive (P67775)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDCA4 | RAB11FIP5 | 0.956 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IGFBP5 | PPP2R2D | 0.951 | 0.034 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXL16 | PPP2R2A | 0.927 |
mutually_exclusive (P67775)
|
hein_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| FBXL16 | RAB11FIP5 | 0.818 | hein_WMM bioplex3_WMM WMM_only | ||
| FBXL16 | IER5L | 0.688 |
mutually_exclusive (Q00005)
|
bioplex3_WMM WMM_only | |
| IER5L | PPP2R2A | 0.587 | bioplex3_WMM WMM_only | ||
| IER5L | CDCA4 | 0.455 |
mutually_exclusive (Q00005)
|
bioplex3_WMM WMM_only | |
| IER5L | RAB11FIP5 | 0.32 |
mutually_exclusive (Q00005)
|
bioplex3_WMM WMM_only |
Related Complexes