hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06553.1
Complex Portal: CPX-24831
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 3.91945798564e-08 | 1.0 | CAMK2D CAMK2B CAMK2A | CaMK IV-mediated phosphorylation of CREB |
| REAC:R-HSA-442982 | 1.69843179378e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Ras activation upon Ca2+ influx through NMDA receptor |
| WP:WP4875 | 1.78287172964e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Disruption of postsynaptic signaling by CNV |
| REAC:R-HSA-9617324 | 3.1728945598e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-438066 | 3.1728945598e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9620244 | 3.80747347177e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Long-term potentiation |
| GO:0005954 | 3.84480164306e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | calcium- and calmodulin-dependent protein kinase complex |
| WP:WP4756 | 4.63856714356e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Renin angiotensin aldosterone system RAAS |
| WP:WP4008 | 6.02300579971e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | NO cGMP PKG mediated neuroprotection |
| REAC:R-HSA-442742 | 7.18567297368e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-3371571 | 8.26352391973e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | HSF1-dependent transactivation |
| REAC:R-HSA-5576892 | 9.44402733683e-07 | 1.0 | CAMK2D CAMK2B CAMK2A | Phase 0 - rapid depolarisation |
| REAC:R-HSA-399719 | 1.07318492464e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 1.07318492464e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| KEGG:04971 | 1.22375439253e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Gastric acid secretion |
| KEGG:04720 | 1.29573994503e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Long-term potentiation |
| KEGG:05031 | 1.52851760973e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Amphetamine addiction |
| REAC:R-HSA-9022692 | 1.70496422375e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Regulation of MECP2 expression and activity |
| REAC:R-HSA-111997 | 1.89440469306e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | CaM pathway |
| REAC:R-HSA-5673000 | 1.89440469306e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | RAF activation |
| REAC:R-HSA-111933 | 1.89440469306e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Calmodulin induced events |
| KEGG:04911 | 2.28180619251e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Insulin secretion |
| REAC:R-HSA-111996 | 2.31434662009e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Ca-dependent events |
| KEGG:04912 | 2.61801737967e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | GnRH signaling pathway |
| KEGG:05214 | 2.61801737967e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Glioma |
| KEGG:04750 | 2.73701816965e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-9656223 | 3.05391101381e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling by RAF1 mutants |
| WP:WP4341 | 3.07824431547e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04713 | 3.24906634499e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Circadian entrainment |
| REAC:R-HSA-1489509 | 3.3315392878e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | DAG and IP3 signaling |
| KEGG:04925 | 3.38635083845e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Aldosterone synthesis and secretion |
| KEGG:04012 | 3.67241243895e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | ErbB signaling pathway |
| REAC:R-HSA-936837 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Ion transport by P-type ATPases |
| REAC:R-HSA-9609736 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-6802955 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 3.93625566272e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling downstream of RAS mutants |
| KEGG:04740 | 4.62629936833e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Olfactory transduction |
| KEGG:04916 | 4.79978559464e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Melanogenesis |
| REAC:R-HSA-5578775 | 4.97397882464e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Ion homeostasis |
| REAC:R-HSA-112043 | 5.35659258038e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | PLC beta mediated events |
| KEGG:04725 | 5.93248714392e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Cholinergic synapse |
| KEGG:04922 | 6.56019280347e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Glucagon signaling pathway |
| WP:WP673 | 6.61367895536e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | ErbB signaling pathway |
| REAC:R-HSA-112040 | 7.56595371871e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | G-protein mediated events |
| KEGG:04066 | 8.19365887109e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | HIF-1 signaling pathway |
| KEGG:04722 | 8.44707100112e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Neurotrophin signaling pathway |
| KEGG:04114 | 9.51295867401e-06 | 1.0 | CAMK2D CAMK2B CAMK2A | Oocyte meiosis |
| REAC:R-HSA-8986944 | 1.09306217585e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Transcriptional Regulation by MECP2 |
| KEGG:04728 | 1.09667742953e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Dopaminergic synapse |
| WP:WP428 | 1.29180684237e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Wnt signaling |
| REAC:R-HSA-6802952 | 1.29342113526e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling by BRAF and RAF1 fusions |
| KEGG:04921 | 1.39434656978e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Oxytocin signaling pathway |
| KEGG:04261 | 1.43040725693e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Adrenergic signaling in cardiomyocytes |
| KEGG:04148 | 1.62006150102e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Efferocytosis |
| KEGG:04934 | 1.65989907892e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Cushing syndrome |
| WP:WP5083 | 1.71942475092e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Neuroinflammation and glutamatergic signaling |
| WP:WP536 | 1.76674836791e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Calcium regulation in cardiac cells |
| KEGG:04217 | 2.18996976196e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Necroptosis |
| REAC:R-HSA-438064 | 2.33842329058e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Post NMDA receptor activation events |
| KEGG:05152 | 2.65416687338e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Tuberculosis |
| REAC:R-HSA-6802957 | 2.66686453773e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Oncogenic MAPK signaling |
| WP:WP289 | 2.83821551935e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Myometrial relaxation and contraction pathways |
| KEGG:04310 | 2.8799444916e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Wnt signaling pathway |
| KEGG:04360 | 3.11817592384e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Axon guidance |
| REAC:R-HSA-877300 | 3.28021305227e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Interferon gamma signaling |
| KEGG:04024 | 3.36919550068e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | cAMP signaling pathway |
| REAC:R-HSA-111885 | 3.549722449e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Opioid Signalling |
| REAC:R-HSA-442755 | 3.83360319167e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Activation of NMDA receptors and postsynaptic events |
| KEGG:04020 | 4.35329755601e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Calcium signaling pathway |
| REAC:R-HSA-3371556 | 4.60862934812e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Cellular response to heat stress |
| REAC:R-HSA-5576891 | 4.60862934812e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Cardiac conduction |
| KEGG:05417 | 4.99333165562e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Lipid and atherosclerosis |
| KEGG:05205 | 5.16258651055e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Proteoglycans in cancer |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | CAMK2D CAMK2B CAMK2A | Diabetic cardiomyopathy |
| KEGG:05012 | 0.00011589966492 | 1.0 | CAMK2D CAMK2B CAMK2A | Parkinson disease |
| REAC:R-HSA-983712 | 0.000144704522421 | 1.0 | CAMK2D CAMK2B CAMK2A | Ion channel transport |
| GO:0004683 | 0.000148024863258 | 1.0 | CAMK2D CAMK2B CAMK2A | calmodulin-dependent protein kinase activity |
| WP:WP5231 | 0.000193548942551 | 0.666666666667 | CAMK2B CAMK2A | Hippocampal synaptogenesis and neurogenesis |
| REAC:R-HSA-397014 | 0.000257237760415 | 1.0 | CAMK2D CAMK2B CAMK2A | Muscle contraction |
| REAC:R-HSA-112314 | 0.000300937850546 | 1.0 | CAMK2D CAMK2B CAMK2A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-913531 | 0.000409665014874 | 1.0 | CAMK2D CAMK2B CAMK2A | Interferon Signaling |
| REAC:R-HSA-418594 | 0.000492377243425 | 1.0 | CAMK2D CAMK2B CAMK2A | G alpha (i) signalling events |
| KEGG:05022 | 0.000613327564103 | 1.0 | CAMK2D CAMK2B CAMK2A | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-112315 | 0.000640971827897 | 1.0 | CAMK2D CAMK2B CAMK2A | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 0.000740957667713 | 1.0 | CAMK2D CAMK2B CAMK2A | RAF/MAP kinase cascade |
| KEGG:05200 | 0.000767224943957 | 1.0 | CAMK2D CAMK2B CAMK2A | Pathways in cancer |
| REAC:R-HSA-5684996 | 0.000783695624229 | 1.0 | CAMK2D CAMK2B CAMK2A | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 0.00118616050146 | 1.0 | CAMK2D CAMK2B CAMK2A | MAPK family signaling cascades |
| REAC:R-HSA-9006925 | 0.001430872794 | 1.0 | CAMK2D CAMK2B CAMK2A | Intracellular signaling by second messengers |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | CAMK2D CAMK2B CAMK2A | Neuronal System |
| REAC:R-HSA-388396 | 0.00381272507886 | 1.0 | CAMK2D CAMK2B CAMK2A | GPCR downstream signalling |
| REAC:R-HSA-5663202 | 0.00393910426879 | 1.0 | CAMK2D CAMK2B CAMK2A | Diseases of signal transduction by growth factor receptors and second messengers |
| GO:0010666 | 0.00421361424067 | 0.666666666667 | CAMK2D CAMK2A | positive regulation of cardiac muscle cell apoptotic process |
| GO:0010663 | 0.00421361424067 | 0.666666666667 | CAMK2D CAMK2A | positive regulation of striated muscle cell apoptotic process |
| REAC:R-HSA-372790 | 0.00563898766183 | 1.0 | CAMK2D CAMK2B CAMK2A | Signaling by GPCR |
| WP:WP4549 | 0.0067573392711 | 0.666666666667 | CAMK2B CAMK2A | Fragile X syndrome |
| GO:0005516 | 0.00851239083773 | 1.0 | CAMK2D CAMK2B CAMK2A | calmodulin binding |
| REAC:R-HSA-382551 | 0.0117092435511 | 1.0 | CAMK2D CAMK2B CAMK2A | Transport of small molecules |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | CAMK2D CAMK2B CAMK2A | Cytokine Signaling in Immune system |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | CAMK2D CAMK2B CAMK2A | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | CAMK2D CAMK2B CAMK2A | Cellular responses to stimuli |
| GO:0051924 | 0.0411908979227 | 1.0 | CAMK2D CAMK2B CAMK2A | regulation of calcium ion transport |
| GO:0030666 | 0.0488366704701 | 1.0 | CAMK2D CAMK2B CAMK2A | endocytic vesicle membrane |
| CORUM:5655 | 0.0499402709677 | 0.333333333333 | CAMK2A | Ternary complex (LRRC7, CAMK2a, ACTN4) |
| CORUM:6517 | 0.0499402709677 | 0.333333333333 | CAMK2A | SERCA2a-alphaKAP-CaM-CaMKII complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | ||
| CAMK2D | CAMK2A | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| CAMK2B | CAMK2A | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes