hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06555.1

Complex Portal: CPX-16250

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
COL13A1	Collagen alpha-1(XIII) chain (COLXIIIA1)	5	UniProt NCBI
COL5A2	Collagen alpha-2(V) chain	5	UniProt NCBI
C1QTNF9B	Complement C1q and tumor necrosis factor-related protein 9B (C1q/TNF-related protein 9B) (CTRP9B) (Complement C1q and tumor necrosis factor-related protein 9-like)	4	UniProt NCBI
PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	5	UniProt NCBI
COLEC11	Collectin-11 (Collectin kidney protein 1) (CL-K1)	5	UniProt NCBI
C1QTNF3	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	5	UniProt NCBI
COL4A2	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	5	UniProt NCBI
COL6A1	Collagen alpha-1(VI) chain	5	UniProt NCBI
RITA1	RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)	5	UniProt NCBI
PLOD2	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)	5	UniProt NCBI
COL18A1	Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]	5	UniProt NCBI
COL9A3	Collagen alpha-3(IX) chain	5	UniProt NCBI
COL5A1	Collagen alpha-1(V) chain	5	UniProt NCBI
COLGALT1	Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	8.50350749169e-18	0.692307692308	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	1.95752576394e-16	0.692307692308	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	Collagen formation
REAC:R-HSA-1474244	8.65125002987e-12	0.692307692308	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	Extracellular matrix organization
REAC:R-HSA-8948216	2.03872783836e-11	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	Collagen chain trimerization
REAC:R-HSA-1442490	4.76395468187e-10	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	Collagen degradation
GO:0005581	6.3610961755e-10	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	collagen trimer
KEGG:04974	8.48089016928e-10	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	Protein digestion and absorption
REAC:R-HSA-216083	2.30143513928e-09	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	Integrin cell surface interactions
GO:0030020	2.98592534115e-09	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	extracellular matrix structural constituent conferring tensile strength
GO:0043062	1.91289366491e-08	0.615384615385	COL13A1 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	extracellular structure organization
GO:0030198	1.91289366491e-08	0.615384615385	COL13A1 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	extracellular matrix organization
GO:0045229	2.10100597522e-08	0.615384615385	COL13A1 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	external encapsulating structure organization
REAC:R-HSA-1474228	5.35752185098e-08	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	Degradation of the extracellular matrix
REAC:R-HSA-2022090	9.52921135212e-08	0.384615384615	COL9A3 COL18A1 COL5A1 COL5A2 COL4A2	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-419037	1.78390160965e-06	0.307692307692	COL9A3 COL5A1 COL5A2 COL4A2	NCAM1 interactions
GO:0030199	5.72981326005e-06	0.384615384615	COL18A1 COLGALT1 COL5A1 COL5A2 PLOD3	collagen fibril organization
REAC:R-HSA-375165	1.1293428452e-05	0.307692307692	COL9A3 COL5A1 COL5A2 COL4A2	NCAM signaling for neurite out-growth
GO:0005201	1.61868727354e-05	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	extracellular matrix structural constituent
REAC:R-HSA-186797	1.95745243779e-05	0.307692307692	COL9A3 COL5A1 COL5A2 COL4A2	Signaling by PDGF
HP:0009811	2.44325848294e-05	0.461538461538	COL9A3 PLOD2 COL5A2 PLOD3 COLEC11 COL5A1	Abnormality of the elbow
GO:0005788	2.84728597134e-05	0.538461538462	COL9A3 COL13A1 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1	endoplasmic reticulum lumen
HP:0025019	3.19898255905e-05	0.230769230769	COL5A1 COL5A2 PLOD3	Arterial rupture
REAC:R-HSA-3000178	4.24708464477e-05	0.307692307692	COL9A3 COL5A1 COL5A2 COL4A2	ECM proteoglycans
WP:WP2911	5.20093389321e-05	0.230769230769	COL5A1 COL5A2 COL4A2	miRNA targets in ECM and membrane receptors
CORUM:6997	0.00012303818858	0.153846153846	COLGALT1 PLOD3	ADIPOQ-PLOD3-GLT25D1 complex
KEGG:00310	0.000943491618216	0.230769230769	COLGALT1 PLOD3 PLOD2	Lysine degradation
HP:0034430	0.00124932371235	0.615384615385	COL13A1 PLOD2 COL9A3 COL5A2 PLOD3 COL18A1 COLEC11 COL5A1	Abnormal joint physiology
HP:0011729	0.00124932371235	0.615384615385	COL13A1 PLOD2 COL9A3 COL5A2 PLOD3 COL18A1 COLEC11 COL5A1	Abnormality of joint mobility
HP:0009810	0.00160022694071	0.461538461538	COL9A3 PLOD2 COL5A2 PLOD3 COLEC11 COL5A1	Abnormality of upper limb joint
HP:0001382	0.00174400719007	0.461538461538	COL9A3 COL13A1 COL5A2 COLEC11 COL18A1 COL5A1	Joint hypermobility
HP:0002132	0.00206494539291	0.230769230769	COLGALT1 PLOD3 COL4A2	Porencephalic cyst
HP:0025509	0.00228133307992	0.153846153846	COL5A2 COL5A1	Piezogenic pedal papules
HP:0025014	0.00228133307992	0.153846153846	COL5A2 COL5A1	Subcutaneous spheroids
REAC:R-HSA-3000171	0.00253884618379	0.230769230769	COL5A1 COL5A2 COL4A2	Non-integrin membrane-ECM interactions
HP:0100659	0.00406163628839	0.384615384615	COLGALT1 COL5A1 COL4A2 COL5A2 PLOD3	Abnormal cerebral vascular morphology
HP:0004872	0.0045603764747	0.153846153846	COL5A2 COL5A1	Incisional hernia
HP:0030009	0.0045603764747	0.153846153846	COL5A2 COL5A1	Cervical insufficiency
HP:0002996	0.00486153226598	0.307692307692	COL9A3 COLEC11 PLOD3 PLOD2	Limited elbow movement
GO:0062023	0.0055173965507	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	collagen-containing extracellular matrix
HP:0011843	0.00562413958304	0.615384615385	COL13A1 PLOD2 COL9A3 COL5A2 PLOD3 COL18A1 COLEC11 COL5A1	Abnormal musculoskeletal physiology
HP:0001384	0.00610532856973	0.384615384615	COL9A3 COL13A1 COL5A1 COL5A2 COLEC11	Abnormal hip joint morphology
HP:0025323	0.00700506604878	0.307692307692	COLGALT1 COL5A1 COL5A2 PLOD3	Abnormal arterial physiology
HP:0100491	0.00758965749681	0.461538461538	COL9A3 PLOD2 COL13A1 COL5A2 COLEC11 COL5A1	Abnormality of lower limb joint
HP:0000993	0.00759681327472	0.153846153846	COL5A2 COL5A1	Molluscoid pseudotumors
HP:0003771	0.00759681327472	0.153846153846	COL5A2 COL5A1	Pulp calcification
HP:0004944	0.00795339328573	0.230769230769	COL5A1 COL5A2 PLOD3	Dilatation of the cerebral artery
HP:0002758	0.00795339328573	0.230769230769	COL9A3 COL5A2 COL5A1	Osteoarthritis
HP:0001367	0.00935025175827	0.538461538462	COL13A1 PLOD2 COL9A3 COL5A2 PLOD3 COLEC11 COL5A1	Abnormal joint morphology
GO:0098644	0.00995012273459	0.230769230769	COL5A1 COL5A2 COL4A2	complex of collagen trimers
HP:0009763	0.0103053160575	0.230769230769	COL9A3 COL5A2 COL5A1	Limb pain
HP:0100823	0.0113895015741	0.153846153846	COL5A2 COL5A1	Genital hernia
HP:0010749	0.0113895015741	0.153846153846	COL5A2 COL5A1	Blepharochalasis
HP:0006243	0.0113895015741	0.153846153846	COL5A2 COL5A1	Phalangeal dislocation
HP:0000139	0.0113895015741	0.153846153846	COL5A2 COL5A1	Uterine prolapse
GO:0005783	0.0148266902732	0.692307692308	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COL5A1 PLOD3	endoplasmic reticulum
HP:0010750	0.01593730064	0.153846153846	COL5A2 COL5A1	Dermatochalasis
HP:0002818	0.0165721795618	0.307692307692	COLEC11 COL5A1 COL5A2 COL9A3	Abnormal morphology of the radius
GO:0030312	0.0183733258262	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	external encapsulating structure
GO:0031012	0.0183733258262	0.461538461538	COL9A3 COL13A1 COL5A2 COL4A2 COL18A1 COL5A1	extracellular matrix
HP:0040072	0.0221190077454	0.307692307692	COLEC11 COL5A1 COL5A2 COL9A3	Abnormal forearm bone morphology
HP:0002973	0.0225615292021	0.307692307692	COLEC11 COL5A1 COL5A2 COL9A3	Abnormal forearm morphology
HPA:0461433	0.0249306925292	0.153846153846	COL18A1 COL4A2	skin 1; extracellular matrix[High]
REAC:R-HSA-3000480	0.0269367236592	0.153846153846	COLEC11 COL4A2	Scavenging by Class A Receptors
HPA:0471433	0.0272913447162	0.153846153846	COL18A1 COL4A2	skin 2; extracellular matrix[High]
HP:0004947	0.0272936739987	0.153846153846	COL5A2 COL5A1	Arteriovenous fistula
HP:0009145	0.0302896654553	0.230769230769	COL5A1 COL5A2 PLOD3	Abnormal cerebral artery morphology
HP:0033127	0.0305004578248	0.769230769231	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COLEC11 COL5A1 PLOD3	Abnormality of the musculoskeletal system
KEGG:00514	0.031976259245	0.153846153846	COLGALT1 PLOD3	Other types of O-glycan biosynthesis
HP:0002827	0.0340485765369	0.307692307692	COL13A1 COL5A1 COL5A2 COLEC11	Hip dislocation
HP:0001073	0.0340999726817	0.153846153846	COL5A2 COL5A1	Cigarette-paper scars
GO:1903225	0.0365196561665	0.153846153846	COL5A2 COL5A1	negative regulation of endodermal cell differentiation
GO:0005588	0.0365196561665	0.153846153846	COL5A2 COL5A1	collagen type V trimer
WP:WP4786	0.0391034347791	0.153846153846	COLGALT1 PLOD2	Type I collagen synthesis in the context of osteogenesis imperfecta
HP:0003011	0.0402847448731	0.692307692308	COL13A1 PLOD2 COL9A3 COL5A2 COLGALT1 COL4A2 COLEC11 COL5A1 PLOD3	Abnormality of the musculature
HP:0003272	0.0407284871829	0.384615384615	COL9A3 COL13A1 COL5A1 COL5A2 COLEC11	Abnormal hip bone morphology
HP:0012759	0.0453172641829	0.692307692308	COL13A1 COL9A3 COL5A2 COLGALT1 COL4A2 COL18A1 COLEC11 COL5A1 PLOD3	Neurodevelopmental abnormality
REAC:R-HSA-3000170	0.0456381529906	0.153846153846	COL5A2 COL5A1	Syndecan interactions
HP:0005294	0.0499631138006	0.153846153846	COL5A2 COL5A1	Arterial dissection
HP:0001027	0.0499631138006	0.153846153846	COL5A2 COL5A1	Soft, doughy skin
HP:0012888	0.0499631138006	0.153846153846	COL5A2 COL5A1	Abnormal uterine cervix morphology

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PLOD3	COLGALT1	1.0	0.55	structurally_consistent (Q02809)
PLOD3	PLOD2	1.0		mutually_exclusive (Q02809) structurally_consistent (dimer)
PLOD2	COLGALT1	0.999		structurally_consistent (Q02809)
PLOD3	C1QTNF9B	0.996
COL5A1	PLOD3	0.996	0.166
PLOD3	COL18A1	0.995	0.164
COLGALT1	C1QTNF9B	0.994
PLOD3	COLEC11	0.994
PLOD2	C1QTNF9B	0.993
PLOD3	COL6A1	0.993	0.146
COL5A1	COLGALT1	0.992	0.118
COLEC11	PLOD2	0.991
COL5A2	COL5A1	0.991	0.444
C1QTNF9B	COL6A1	0.988
PLOD3	C1QTNF3	0.987
COL18A1	C1QTNF9B	0.984
COL9A3	PLOD3	0.978
PLOD3	RITA1	0.972
COL13A1	PLOD3	0.971
COLEC11	COL6A1	0.967
RITA1	COLGALT1	0.963
C1QTNF3	COLGALT1	0.958
COLGALT1	COL6A1	0.957	0.106
COL5A2	PLOD3	0.956	0.112
COL4A2	PLOD3	0.955	0.174
COL5A2	COLGALT1	0.952	0.132
C1QTNF3	PLOD2	0.939
COL4A2	COL5A1	0.928	0.262
PLOD2	COL6A1	0.909
COLEC11	COLGALT1	0.882
PLOD2	COL18A1	0.842
COL18A1	COL6A1	0.831	0.432
COL18A1	COLGALT1	0.801	0.122
COL13A1	PLOD2	0.745
COL13A1	COL18A1	0.733
COL5A1	COL18A1	0.724	0.282
COL4A2	COL6A1	0.686	0.536
COL13A1	COL6A1	0.682
COL13A1	COLGALT1	0.629
COL5A1	COL6A1	0.619	0.318
RITA1	PLOD2	0.532
COL4A2	COL18A1	0.509	0.51
COL4A2	PLOD2	0.508
COL13A1	COL9A3	0.455
COL4A2	COLGALT1	0.416	0.09
COL4A2	C1QTNF9B	0.414
COL4A2	RITA1	0.403
COL9A3	COLGALT1	0.402
COL9A3	COL18A1	0.402
COL9A3	COL6A1	0.348
COL9A3	PLOD2	0.348
COL4A2	COL13A1	0.326
COL5A1	PLOD2	0.291
COL13A1	COL5A2	0.278
COL13A1	COL5A1	0.262
COL4A2	COL9A3	0.072
COL4A2	COL5A2	0.065	0.236
RITA1	COL6A1	0.064
COL5A2	PLOD2	0.06
COL5A2	COL6A1	0.058	0.35
COL5A2	COL18A1	0.056	0.362
RITA1	COL18A1	0.049
COL9A3	COL5A1	0.043
COL4A2	COLEC11	0.038
COLEC11	COL18A1	0.03
C1QTNF3	COL6A1	0.023

Related Complexes

Genename	Complexes
COL13A1	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_04420.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL5A2	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1
C1QTNF9B	huMAP3_03042.1 huMAP3_06555.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1
PLOD3	huMAP3_02991.1 huMAP3_03159.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COLEC11	huMAP3_02991.1 huMAP3_06555.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_12819.1 huMAP3_13038.1 huMAP3_14072.1
C1QTNF3	huMAP3_02991.1 huMAP3_06555.1 huMAP3_06962.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_11684.1 huMAP3_13038.1
COL4A2	huMAP3_00257.1 huMAP3_00858.1 huMAP3_02991.1 huMAP3_04937.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
COL6A1	huMAP3_06555.1 huMAP3_09427.1
RITA1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1
PLOD2	huMAP3_02991.1 huMAP3_06555.1 huMAP3_08295.1 huMAP3_09335.1 huMAP3_09435.1 huMAP3_10567.1 huMAP3_10699.1 huMAP3_12184.1 huMAP3_13038.1
COL18A1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_06555.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COL9A3	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
COL5A1	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
COLGALT1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06555.1

Complex Portal: CPX-16250