hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06561.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-oxosteroid reductase) (EC 1.1.1.201) (Corticosteroid 11-beta-dehydrogenase isozyme 1) (Short chain dehydrogenase/reductase family 26C member 1) | 5 | UniProt NCBI |
| INSR | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3634 | 0.0363468011862 | 1.0 | INSR | Insulin signaling in adipocytes normal condition |
| WP:WP3635 | 0.0363468011862 | 1.0 | INSR | Insulin signaling in adipocytes diabetic condition |
| WP:WP5400 | 0.0408901513344 | 1.0 | INSR | 6q16 copy number variation |
| KEGG:04960 | 0.0481851079105 | 1.0 | INSR | Aldosterone-regulated sodium reabsorption |
| HP:0004914 | 0.0495817777049 | 1.0 | INSR | Recurrent infantile hypoglycemia |
| HP:0012684 | 0.0495817777049 | 1.0 | INSR | Abnormal pineal volume |
| HP:0012686 | 0.0495817777049 | 1.0 | INSR | Increased pineal volume |
| HP:0034384 | 0.0495817777049 | 1.0 | INSR | Elevated circulating insulin:C-peptide ratio |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSD11B1 | INSR | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| HSD11B1 | huMAP3_01368.1 huMAP3_04935.1 huMAP3_06561.1 huMAP3_09799.1 huMAP3_10145.1 huMAP3_11006.1 |
| INSR | huMAP3_02023.1 huMAP3_04935.1 huMAP3_06561.1 huMAP3_08471.1 huMAP3_11006.1 |