hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06565.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB7A | Ras-related protein Rab-7a (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAB10 | Ras-related protein Rab-10 (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAB6A | Ras-related protein Rab-6A (Rab-6) | 5 | UniProt NCBI |
| RAB5A | Ras-related protein Rab-5A (EC 3.6.5.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 5.35706921361e-08 | 1.0 | RAB10 RAB5A RAB7A RAB6A | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 1.59771447866e-07 | 1.0 | RAB10 RAB5A RAB7A RAB6A | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 5.14641931672e-07 | 1.0 | RAB10 RAB5A RAB7A RAB6A | Rab regulation of trafficking |
| REAC:R-HSA-8854214 | 1.28002609524e-05 | 0.75 | RAB6A RAB7A RAB5A | TBC/RABGAPs |
| REAC:R-HSA-9636383 | 0.000368856835097 | 0.5 | RAB7A RAB5A | Prevention of phagosomal-lysosomal fusion |
| REAC:R-HSA-199991 | 0.000426838992032 | 1.0 | RAB10 RAB5A RAB7A RAB6A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000530772712934 | 1.0 | RAB10 RAB5A RAB7A RAB6A | Vesicle-mediated transport |
| KEGG:04144 | 0.000687966939719 | 0.75 | RAB10 RAB7A RAB5A | Endocytosis |
| REAC:R-HSA-9637687 | 0.000798898068561 | 0.5 | RAB7A RAB5A | Suppression of phagosomal maturation |
| GO:0005525 | 0.000993378785041 | 1.0 | RAB10 RAB5A RAB7A RAB6A | GTP binding |
| GO:0032561 | 0.00156892706691 | 1.0 | RAB10 RAB5A RAB7A RAB6A | guanyl ribonucleotide binding |
| GO:0019001 | 0.00160144369006 | 1.0 | RAB10 RAB5A RAB7A RAB6A | guanyl nucleotide binding |
| REAC:R-HSA-9637690 | 0.00258893271292 | 0.5 | RAB7A RAB5A | Response of Mtb to phagocytosis |
| REAC:R-HSA-9635486 | 0.00332479301982 | 0.5 | RAB7A RAB5A | Infection with Mycobacterium tuberculosis |
| GO:0016197 | 0.00379124230895 | 1.0 | RAB10 RAB5A RAB7A RAB6A | endosomal transport |
| KEGG:05146 | 0.00909742323246 | 0.5 | RAB7A RAB5A | Amoebiasis |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | RAB10 RAB5A RAB7A RAB6A | Post-translational protein modification |
| KEGG:04137 | 0.0118173906169 | 0.5 | RAB7A RAB5A | Mitophagy - animal |
| GO:0019003 | 0.0152210712647 | 0.75 | RAB10 RAB7A RAB5A | GDP binding |
| WP:WP4217 | 0.0168573248614 | 0.5 | RAB7A RAB5A | Ebola virus infection in host |
| REAC:R-HSA-9824439 | 0.0174510452107 | 0.5 | RAB7A RAB5A | Bacterial Infection Pathways |
| REAC:R-HSA-6798695 | 0.0179349264259 | 0.75 | RAB10 RAB7A RAB6A | Neutrophil degranulation |
| KEGG:04148 | 0.0189154103852 | 0.5 | RAB7A RAB5A | Efferocytosis |
| KEGG:04145 | 0.0214296747035 | 0.5 | RAB7A RAB5A | Phagosome |
| KEGG:05152 | 0.02620193588 | 0.5 | RAB7A RAB5A | Tuberculosis |
| GO:0035639 | 0.0326761482103 | 1.0 | RAB10 RAB5A RAB7A RAB6A | purine ribonucleoside triphosphate binding |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | RAB10 RAB5A RAB7A RAB6A | Metabolism of proteins |
| HPA:0480053 | 0.048862114603 | 1.0 | RAB10 RAB5A RAB7A RAB6A | small intestine; glandular cells[High] |
| CORUM:2572 | 0.049938562206 | 0.25 | RAB5A | RAB5-EEA1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAB10 | RAB7A | 0.994 | 0.388 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB10 | RAB6A | 0.974 | 0.5 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| RAB5A | RAB7A | 0.968 | 0.346 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB7A | RAB6A | 0.96 | 0.396 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| RAB5A | RAB6A | 0.953 | 0.342 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| RAB5A | RAB10 | 0.65 | 0.596 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes