hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06571.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DICER1 | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | 5 | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | 5 | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | 5 | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426486 | 1.20999690042e-11 | 1.0 | AGO1 DICER1 AGO3 AGO2 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-203927 | 8.50358932796e-10 | 1.0 | AGO1 DICER1 AGO3 AGO2 | MicroRNA (miRNA) biogenesis |
| GO:0070578 | 1.84188417064e-09 | 1.0 | AGO1 DICER1 AGO3 AGO2 | RISC-loading complex |
| GO:0070922 | 5.52565251192e-09 | 1.0 | AGO1 DICER1 AGO3 AGO2 | RISC complex assembly |
| GO:0031332 | 2.63389436402e-08 | 1.0 | AGO1 DICER1 AGO3 AGO2 | RNAi effector complex |
| GO:0016442 | 2.63389436402e-08 | 1.0 | AGO1 DICER1 AGO3 AGO2 | RISC complex |
| GO:0031054 | 4.78889884367e-08 | 1.0 | AGO1 DICER1 AGO3 AGO2 | pre-miRNA processing |
| REAC:R-HSA-426496 | 4.91023464396e-08 | 0.75 | AGO2 AGO3 AGO1 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 7.85597209803e-08 | 0.75 | AGO2 AGO3 AGO1 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-9768778 | 7.85597209803e-08 | 0.75 | AGO2 AGO3 AGO1 | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8943723 | 1.17833531486e-07 | 0.75 | AGO2 AGO3 AGO1 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 1.68324973574e-07 | 0.75 | AGO2 AGO3 AGO1 | Regulation of NPAS4 gene expression |
| REAC:R-HSA-211000 | 7.36929886059e-07 | 1.0 | AGO1 DICER1 AGO3 AGO2 | Gene Silencing by RNA |
| GO:1902555 | 8.27926934703e-07 | 1.0 | AGO1 DICER1 AGO3 AGO2 | endoribonuclease complex |
| REAC:R-HSA-8934593 | 9.53498684462e-07 | 0.75 | AGO2 AGO3 AGO1 | Regulation of RUNX1 Expression and Activity |
| GO:1905348 | 1.37772935964e-06 | 1.0 | AGO1 DICER1 AGO3 AGO2 | endonuclease complex |
| GO:0035196 | 1.94226685794e-06 | 1.0 | AGO1 DICER1 AGO3 AGO2 | miRNA processing |
| GO:0061980 | 2.16424021313e-06 | 1.0 | AGO1 DICER1 AGO3 AGO2 | regulatory RNA binding |
| REAC:R-HSA-9634815 | 4.59102468944e-06 | 0.75 | AGO2 AGO3 AGO1 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 5.12049513312e-06 | 0.75 | AGO2 AGO3 AGO1 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 6.29837429836e-06 | 0.75 | AGO2 AGO3 AGO1 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| GO:0070918 | 8.97405436883e-06 | 1.0 | AGO1 DICER1 AGO3 AGO2 | regulatory ncRNA processing |
| GO:0003725 | 9.66436624335e-06 | 1.0 | AGO1 DICER1 AGO3 AGO2 | double-stranded RNA binding |
| REAC:R-HSA-9024446 | 1.28002609524e-05 | 0.75 | AGO2 AGO3 AGO1 | NR1H2 and NR1H3-mediated signaling |
| GO:0016441 | 1.28309598221e-05 | 1.0 | AGO1 DICER1 AGO3 AGO2 | post-transcriptional gene silencing |
| CORUM:5377 | 1.53774525569e-05 | 0.5 | DICER1 AGO2 | RNA-induced silencing complex, RISC |
| CORUM:1385 | 1.53774525569e-05 | 0.5 | DICER1 AGO2 | DICER1-NCOA6-AGO2 complex |
| CORUM:5381 | 1.53774525569e-05 | 0.5 | DICER1 AGO2 | RNA-induced silencing complex, RISC |
| CORUM:3032 | 3.07520988333e-05 | 0.5 | DICER1 AGO2 | RNA-induced silencing complex, RISC |
| GO:0010501 | 3.22863876272e-05 | 0.75 | AGO2 AGO3 AGO1 | RNA secondary structure unwinding |
| REAC:R-HSA-8986944 | 3.27872895639e-05 | 0.75 | AGO2 AGO3 AGO1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 3.27872895639e-05 | 0.75 | AGO2 AGO3 AGO1 | Ca2+ pathway |
| WP:WP2805 | 3.82933516227e-05 | 0.5 | DICER1 AGO2 | exRNA mechanism of action and biogenesis |
| CORUM:5378 | 7.68662167609e-05 | 0.5 | DICER1 AGO2 | TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) |
| GO:0031047 | 8.0240394575e-05 | 1.0 | AGO1 DICER1 AGO3 AGO2 | regulatory ncRNA-mediated gene silencing |
| REAC:R-HSA-1912408 | 9.82762051365e-05 | 0.75 | AGO2 AGO3 AGO1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 0.000110531761496 | 0.75 | AGO2 AGO3 AGO1 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 0.000119242757257 | 0.75 | AGO2 AGO3 AGO1 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 0.000175410417245 | 0.75 | AGO2 AGO3 AGO1 | Pre-NOTCH Expression and Processing |
| GO:0035278 | 0.000261258639543 | 0.75 | AGO2 AGO3 AGO1 | miRNA-mediated gene silencing by inhibition of translation |
| REAC:R-HSA-9018519 | 0.000464818544718 | 0.75 | AGO2 AGO3 AGO1 | Estrogen-dependent gene expression |
| REAC:R-HSA-6807070 | 0.000558868800628 | 0.75 | AGO2 AGO3 AGO1 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.000571445331233 | 0.75 | AGO2 AGO3 AGO1 | Beta-catenin independent WNT signaling |
| GO:0016891 | 0.000998468305694 | 0.75 | DICER1 AGO3 AGO2 | RNA endonuclease activity, producing 5'-phosphomonoesters |
| WP:WP4844 | 0.00110807642161 | 0.5 | DICER1 AGO2 | Influence of laminopathies on Wnt signaling |
| GO:0022618 | 0.00127030093913 | 1.0 | AGO1 DICER1 AGO3 AGO2 | protein-RNA complex assembly |
| REAC:R-HSA-8939211 | 0.0014432337528 | 0.75 | AGO2 AGO3 AGO1 | ESR-mediated signaling |
| GO:0071826 | 0.00153690814718 | 1.0 | AGO1 DICER1 AGO3 AGO2 | protein-RNA complex organization |
| GO:0035198 | 0.00172575455775 | 0.75 | AGO2 AGO3 AGO1 | miRNA binding |
| REAC:R-HSA-157118 | 0.00193618063067 | 0.75 | AGO2 AGO3 AGO1 | Signaling by NOTCH |
| GO:0016893 | 0.00209449363787 | 0.75 | DICER1 AGO3 AGO2 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| REAC:R-HSA-8878171 | 0.00214268652298 | 0.75 | AGO2 AGO3 AGO1 | Transcriptional regulation by RUNX1 |
| WP:WP4879 | 0.0027493593259 | 0.5 | DICER1 AGO2 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-1257604 | 0.00277575065107 | 0.75 | AGO2 AGO3 AGO1 | PIP3 activates AKT signaling |
| GO:0090624 | 0.0028092043205 | 0.5 | AGO2 AGO3 | endoribonuclease activity, cleaving miRNA-paired mRNA |
| REAC:R-HSA-9006931 | 0.00343792850162 | 0.75 | AGO2 AGO3 AGO1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 0.00352209873575 | 0.75 | AGO2 AGO3 AGO1 | MAPK family signaling cascades |
| GO:0006401 | 0.00404764913615 | 1.0 | AGO1 DICER1 AGO3 AGO2 | RNA catabolic process |
| REAC:R-HSA-9006925 | 0.00424519576246 | 0.75 | AGO2 AGO3 AGO1 | Intracellular signaling by second messengers |
| GO:0035195 | 0.00473512798232 | 0.75 | AGO2 AGO3 AGO1 | miRNA-mediated post-transcriptional gene silencing |
| MIRNA:hsa-miR-107 | 0.005365870902 | 1.0 | AGO1 DICER1 AGO3 AGO2 | hsa-miR-107 |
| REAC:R-HSA-2559585 | 0.00539805716719 | 0.5 | AGO3 AGO1 | Oncogene Induced Senescence |
| REAC:R-HSA-195721 | 0.00597363524476 | 0.75 | AGO2 AGO3 AGO1 | Signaling by WNT |
| REAC:R-HSA-8853884 | 0.0068064250699 | 0.5 | AGO3 AGO1 | Transcriptional Regulation by VENTX |
| REAC:R-HSA-3700989 | 0.00879681508035 | 0.75 | AGO2 AGO3 AGO1 | Transcriptional Regulation by TP53 |
| GO:0035194 | 0.0089837173405 | 0.75 | AGO2 AGO3 AGO1 | regulatory ncRNA-mediated post-transcriptional gene silencing |
| GO:0004521 | 0.0100599149475 | 0.75 | DICER1 AGO3 AGO2 | RNA endonuclease activity |
| REAC:R-HSA-74160 | 0.0112707156575 | 1.0 | AGO1 DICER1 AGO3 AGO2 | Gene expression (Transcription) |
| MIRNA:hsa-miR-148b-3p | 0.0112818436667 | 1.0 | AGO1 DICER1 AGO3 AGO2 | hsa-miR-148b-3p |
| WP:WP4549 | 0.0151597078239 | 0.5 | DICER1 AGO2 | Fragile X syndrome |
| GO:0034470 | 0.0163581002539 | 1.0 | AGO1 DICER1 AGO3 AGO2 | ncRNA processing |
| GO:0003727 | 0.0192043220783 | 0.75 | AGO2 AGO3 AGO1 | single-stranded RNA binding |
| WP:WP2943 | 0.0248784837172 | 0.25 | DICER1 | Hypoxia mediated EMT and stemness |
| CORUM:1387 | 0.0249718442456 | 0.25 | AGO2 | TTP-AGO2 complex |
| GO:0034655 | 0.0252333972666 | 1.0 | AGO1 DICER1 AGO3 AGO2 | nucleobase-containing compound catabolic process |
| GO:0022613 | 0.0254935353828 | 1.0 | AGO1 DICER1 AGO3 AGO2 | ribonucleoprotein complex biogenesis |
| GO:0010608 | 0.0262860281498 | 1.0 | AGO1 DICER1 AGO3 AGO2 | post-transcriptional regulation of gene expression |
| MIRNA:hsa-miR-103a-3p | 0.0296421612139 | 1.0 | AGO1 DICER1 AGO3 AGO2 | hsa-miR-103a-3p |
| REAC:R-HSA-8936459 | 0.0321680026233 | 0.5 | AGO3 AGO1 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| GO:0046700 | 0.0333098536164 | 1.0 | AGO1 DICER1 AGO3 AGO2 | heterocycle catabolic process |
| GO:0044270 | 0.0336301406704 | 1.0 | AGO1 DICER1 AGO3 AGO2 | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.0352663601862 | 1.0 | AGO1 DICER1 AGO3 AGO2 | aromatic compound catabolic process |
| GO:1901361 | 0.0409056153775 | 1.0 | AGO1 DICER1 AGO3 AGO2 | organic cyclic compound catabolic process |
| REAC:R-HSA-5578749 | 0.041644107744 | 0.5 | AGO2 AGO1 | Transcriptional regulation by small RNAs |
| GO:0004519 | 0.0420072408269 | 0.75 | DICER1 AGO3 AGO2 | endonuclease activity |
| CORUM:5360 | 0.049938562206 | 0.25 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.993 | 0.212 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| AGO3 | AGO1 | 0.99 | 0.288 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| AGO3 | AGO2 | 0.976 | 0.268346153846 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| DICER1 | AGO2 | 0.97 | 0.118979591837 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| DICER1 | AGO1 | 0.822 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| DICER1 | AGO3 | 0.812 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
Related Complexes