hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06572.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| ERH | Enhancer of rudimentary homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 3.67150180564e-05 | 0.75 | CHTOP THOC6 THOC3 | mRNA 3'-end processing |
| CORUM:6858 | 5.12488211613e-05 | 0.5 | CHTOP ERH | CHTOP-methylosome complex |
| REAC:R-HSA-73856 | 5.55513549806e-05 | 0.75 | CHTOP THOC6 THOC3 | RNA Polymerase II Transcription Termination |
| GO:0000346 | 6.34131776058e-05 | 0.75 | CHTOP THOC6 THOC3 | transcription export complex |
| REAC:R-HSA-159236 | 7.65476877178e-05 | 0.75 | CHTOP THOC6 THOC3 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:6160 | 7.68662167609e-05 | 0.5 | THOC6 THOC3 | hTREX84 complex |
| CORUM:770 | 0.000107602882996 | 0.5 | THOC6 THOC3 | TREX complex |
| REAC:R-HSA-72202 | 0.000110531761496 | 0.75 | CHTOP THOC6 THOC3 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-72203 | 0.00469213914253 | 0.75 | CHTOP THOC6 THOC3 | Processing of Capped Intron-Containing Pre-mRNA |
| KEGG:03013 | 0.0125523722118 | 0.5 | THOC6 THOC3 | Nucleocytoplasmic transport |
| GO:0006406 | 0.0175369202004 | 0.75 | CHTOP THOC6 THOC3 | mRNA export from nucleus |
| GO:0051028 | 0.0228491864842 | 0.75 | CHTOP THOC6 THOC3 | mRNA transport |
| GO:0006405 | 0.0378152735667 | 0.75 | CHTOP THOC6 THOC3 | RNA export from nucleus |
| GO:0000347 | 0.042122686785 | 0.5 | THOC6 THOC3 | THO complex |
| GO:0000445 | 0.042122686785 | 0.5 | THOC6 THOC3 | THO complex part of transcription export complex |
| CORUM:351 | 0.047170241778 | 0.5 | THOC6 THOC3 | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THOC6 | THOC3 | 1.0 | 0.342 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| ALYREF | CHTOP | 0.999 | 0.572 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| CHTOP | ERH | 0.996 | 0.514 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| THOC3 | ALYREF | 0.984 | 0.246 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| THOC3 | ERH | 0.974 | 0.318 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| THOC6 | CHTOP | 0.972 | 0.146 |
mutually_exclusive (Q96J01)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| THOC3 | CHTOP | 0.97 | 0.134 |
mutually_exclusive (Q96A72)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| THOC6 | ERH | 0.959 | 0.326 | bioplex3_HEK293 bioplex3_WMM youn_WMM fraction | |
| THOC6 | ALYREF | 0.949 | 0.284 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| ALYREF | ERH | 0.85 | 0.594 |
mutually_exclusive (P38919)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
Related Complexes