hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06576.1
Complex Portal: CPX-22170
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLU7 | Pre-mRNA-splicing factor SLU7 (hSlu7) | 5 | UniProt NCBI |
| C1orf52 | UPF0690 protein C1orf52 (BCL10-associated gene protein) | 3 | UniProt NCBI |
| CDC5L | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | 5 | UniProt NCBI |
| GCFC2 | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | 5 | UniProt NCBI |
| YJU2 | Splicing factor YJU2 (Coiled-coil domain-containing protein 94) | 5 | UniProt NCBI |
| PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) | 5 | UniProt NCBI |
| PRPF19 | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | 5 | UniProt NCBI |
| PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | 5 | UniProt NCBI |
| USB1 | U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) | 5 | UniProt NCBI |
| ISY1 | Pre-mRNA-splicing factor ISY1 homolog | 5 | UniProt NCBI |
| CCDC12 | Coiled-coil domain-containing protein 12 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 1.18221227593e-11 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.56079717556e-11 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | mRNA Splicing |
| REAC:R-HSA-72203 | 1.45108678872e-10 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:1181 | 2.64333877911e-10 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | C complex spliceosome |
| GO:0005681 | 6.26619623191e-10 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | spliceosomal complex |
| KEGG:03040 | 3.56686159955e-09 | 0.6 | ISY1 PPIL1 PRPF19 CDC5L CCDC12 SLU7 | Spliceosome |
| CORUM:351 | 9.03386569974e-09 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | Spliceosome |
| REAC:R-HSA-8953854 | 2.21197932626e-07 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | Metabolism of RNA |
| GO:0008380 | 3.08950587726e-07 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L USB1 PPWD1 YJU2 SLU7 | RNA splicing |
| GO:0071013 | 3.84746777847e-07 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | catalytic step 2 spliceosome |
| GO:0005684 | 4.42538373683e-07 | 0.6 | ISY1 PPIL1 CDC5L CCDC12 PRPF19 YJU2 | U2-type spliceosomal complex |
| GO:1990904 | 1.4492580164e-05 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | ribonucleoprotein complex |
| GO:0006396 | 0.000113767423691 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L USB1 PPWD1 YJU2 SLU7 | RNA processing |
| CORUM:1182 | 0.000307240465423 | 0.2 | CDC5L PRPF19 | CDC5L core complex |
| GO:0000377 | 0.000339451176133 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000339451176133 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000371213922121 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0013480773406 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | mRNA processing |
| GO:0140513 | 0.00205875531072 | 0.8 | PPIL1 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 SLU7 | nuclear protein-containing complex |
| GO:0071012 | 0.00252937426606 | 0.3 | ISY1 YJU2 PRPF19 | catalytic step 1 spliceosome |
| GO:0071006 | 0.00252937426606 | 0.3 | ISY1 YJU2 PRPF19 | U2-type catalytic step 1 spliceosome |
| GO:0000974 | 0.00328700479383 | 0.3 | ISY1 CDC5L PRPF19 | Prp19 complex |
| HPA:0270352 | 0.00618262331506 | 0.8 | C1orf52 ISY1 PRPF19 CDC5L CCDC12 PPWD1 YJU2 USB1 | kidney; cells in glomeruli[>=Medium] |
| CORUM:1183 | 0.00915016156996 | 0.2 | CDC5L PRPF19 | CDC5L complex |
| HPA:0400053 | 0.0257128374152 | 0.7 | ISY1 C1orf52 PRPF19 CCDC12 PPWD1 CDC5L YJU2 | rectum; glandular cells[High] |
| GO:0016071 | 0.0266308920315 | 0.6 | ISY1 PPIL1 PRPF19 PPWD1 CDC5L SLU7 | mRNA metabolic process |
| HPA:0050011 | 0.0414593763245 | 0.7 | C1orf52 ISY1 PRPF19 CCDC12 PPWD1 YJU2 USB1 | breast; adipocytes[>=Low] |
| HPA:0460652 | 0.0423171558841 | 0.7 | ISY1 C1orf52 PRPF19 CCDC12 PPWD1 CDC5L YJU2 | skin 1; fibroblasts[>=Medium] |
| GO:0005654 | 0.042696914045 | 1.0 | PPIL1 C1orf52 PRPF19 YJU2 USB1 CCDC12 PPWD1 CDC5L SLU7 ISY1 | nucleoplasm |
| GO:0071007 | 0.0463773280544 | 0.3 | CDC5L PRPF19 PPIL1 | U2-type catalytic step 2 spliceosome |
| HPA:0380523 | 0.0498310928662 | 0.6 | ISY1 C1orf52 CCDC12 CDC5L PRPF19 YJU2 | placenta; trophoblastic cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PRPF19 | CDC5L | 1.0 | 0.508 |
structurally_consistent (dimer)
|
| ISY1 | CDC5L | 1.0 | 0.552 |
structurally_consistent (Q9HCS7)
|
| CCDC12 | PRPF19 | 0.999 | 0.244 |
structurally_consistent (Q9HCS7)
|
| ISY1 | CCDC12 | 0.999 | 0.458 |
structurally_consistent (Q9HCS7)
|
| CCDC12 | CDC5L | 0.999 | 0.526 | |
| GCFC2 | ISY1 | 0.999 | 0.372 | |
| YJU2 | PRPF19 | 0.999 | 0.23 | |
| ISY1 | PRPF19 | 0.998 | 0.266 | |
| YJU2 | CDC5L | 0.998 | 0.7 | |
| CCDC12 | PPIL1 | 0.997 | 0.64 | |
| PRPF19 | PPIL1 | 0.996 | 0.536 |
structurally_consistent (dimer)
|
| ISY1 | PPIL1 | 0.996 | 0.186 | |
| PPIL1 | CDC5L | 0.995 | 0.35 | |
| PPWD1 | CCDC12 | 0.993 | 0.298 | |
| C1orf52 | CCDC12 | 0.99 | 0.132 | |
| SLU7 | CCDC12 | 0.989 | 0.27 | |
| PRPF19 | USB1 | 0.988 |
structurally_consistent (dimer)
|
|
| GCFC2 | PRPF19 | 0.983 | 0.4185 | |
| ISY1 | USB1 | 0.981 | ||
| CCDC12 | USB1 | 0.981 |
structurally_consistent (Q9HCS7)
|
|
| PPWD1 | PRPF19 | 0.978 | 0.22 | |
| GCFC2 | CCDC12 | 0.976 | 0.316 | |
| ISY1 | PPWD1 | 0.973 | 0.282 | |
| PPWD1 | CDC5L | 0.97 | 0.21 | |
| C1orf52 | YJU2 | 0.969 | 0.11 | |
| YJU2 | CCDC12 | 0.968 | 0.358 | |
| USB1 | CDC5L | 0.968 | ||
| SLU7 | ISY1 | 0.959 | 0.31 | |
| C1orf52 | PRPF19 | 0.957 | 0.202 | |
| GCFC2 | PPIL1 | 0.952 | 0.27 | |
| C1orf52 | ISY1 | 0.931 | 0.058 | |
| SLU7 | PRPF19 | 0.888 | 0.628 | |
| YJU2 | ISY1 | 0.879 | 0.394 | |
| SLU7 | C1orf52 | 0.847 | 0.044 | |
| C1orf52 | PPIL1 | 0.832 | 0.042 | |
| C1orf52 | CDC5L | 0.832 | 0.158 | |
| SLU7 | CDC5L | 0.589 | 0.762 | |
| GCFC2 | CDC5L | 0.526 | 0.482 |
mutually_exclusive (O75934)
|
| YJU2 | PPIL1 | 0.398 | 0.078 | |
| GCFC2 | YJU2 | 0.196 | 0.298 |
structurally_consistent (O75934)
|
| YJU2 | PPWD1 | 0.191 | 0.106 | |
| C1orf52 | GCFC2 | 0.161 | 0.136 | |
| SLU7 | PPIL1 | 0.137 | 0.69 |
structurally_consistent (Q96BP3)
|
| PPWD1 | PPIL1 | 0.1 | 0.634 |
mutually_exclusive (P83876)
structurally_consistent (dimer) |
| C1orf52 | PPWD1 | 0.089 | 0.056 | |
| SLU7 | PPWD1 | 0.048 | 0.466 |
mutually_exclusive (P83876)
structurally_consistent (dimer) |
| PPIL1 | USB1 | 0.044 | ||
| SLU7 | GCFC2 | 0.044 | 0.15 | |
| GCFC2 | PPWD1 | 0.016 | 0.652 | |
| SLU7 | YJU2 | 0.009 | 0.2 |
Related Complexes