hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06587.1

Complex Portal: CPX-19796

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)	5	UniProt NCBI
CDK3	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)	5	UniProt NCBI
SKP2	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	5	UniProt NCBI
GMNN	Geminin	5	UniProt NCBI
CCNB1	G2/mitotic-specific cyclin-B1	5	UniProt NCBI
E2F4	Transcription factor E2F4 (E2F-4)	5	UniProt NCBI
CDKN1C	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)	5	UniProt NCBI
CKS1B	Cyclin-dependent kinases regulatory subunit 1 (CKS-1)	5	UniProt NCBI
PCNA	Proliferating cell nuclear antigen (PCNA) (Cyclin)	5	UniProt NCBI
RBL1	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	5	UniProt NCBI
CDK1	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	5	UniProt NCBI
CDK2	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	5	UniProt NCBI
CCNE1	G1/S-specific cyclin-E1	5	UniProt NCBI
MIDEAS	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	4	UniProt NCBI
E2F5	Transcription factor E2F5 (E2F-5)	5	UniProt NCBI
CDT1	DNA replication factor Cdt1 (Double parked homolog) (DUP)	5	UniProt NCBI
CDKN1B	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)	5	UniProt NCBI
CREBBP	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	5	UniProt NCBI
CDK5R1	Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]	5	UniProt NCBI
CCNB2	G2/mitotic-specific cyclin-B2	5	UniProt NCBI
CKS2	Cyclin-dependent kinases regulatory subunit 2 (CKS-2)	4	UniProt NCBI
RBL2	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	5	UniProt NCBI
CCNA2	Cyclin-A2 (Cyclin-A) (Cyclin A)	5	UniProt NCBI
EP300	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	5	UniProt NCBI
CDK5	Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)	5	UniProt NCBI
CCNE2	G1/S-specific cyclin-E2	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04110	2.42290558987e-24	0.714285714286	CCNE2 E2F5 CDK1 RBL1 RBL2 CDKN1C PKMYT1 CREBBP CCNA2 E2F4 CDT1 CCNB2 EP300 SKP2 CDKN1B	Cell cycle
WP:WP179	5.88645195921e-21	0.619047619048	CCNE2 E2F5 CDK1 RBL1 RBL2 CDKN1C PKMYT1 CCNA2 E2F4 EP300 CCNB2 SKP2 CDKN1B	Cell cycle
REAC:R-HSA-453279	3.82337212118e-19	0.619047619048	CCNE2 E2F5 CDK1 GMNN CDKN1C RBL2 CDKN1B CCNA2 CDT1 CKS1B RBL1 SKP2 E2F4	Mitotic G1 phase and G1/S transition
REAC:R-HSA-69206	1.28595816886e-17	0.571428571429	CCNE2 E2F5 CDK1 RBL1 RBL2 CCNA2 CDKN1B CDT1 CKS1B GMNN SKP2 E2F4	G1/S Transition
REAC:R-HSA-69278	3.50180648674e-17	0.761904761905	CCNE2 E2F5 CDK1 GMNN RBL2 CDKN1C PKMYT1 CDKN1B CCNA2 CDT1 CKS1B RBL1 CCNB2 EP300 SKP2 E2F4	Cell Cycle, Mitotic
REAC:R-HSA-1640170	9.64442553462e-16	0.761904761905	CCNE2 E2F5 CDK1 GMNN RBL2 CDKN1C PKMYT1 CDKN1B CCNA2 CDT1 CKS1B RBL1 CCNB2 EP300 SKP2 E2F4	Cell Cycle
REAC:R-HSA-69236	1.20754940826e-15	0.428571428571	E2F5 CCNE2 RBL1 CDKN1C RBL2 CDKN1B CKS1B SKP2 E2F4	G1 Phase
REAC:R-HSA-69231	1.20754940826e-15	0.428571428571	E2F5 CCNE2 RBL1 CDKN1C RBL2 CDKN1B CKS1B SKP2 E2F4	Cyclin D associated events in G1
REAC:R-HSA-6791312	2.64957458964e-13	0.380952380952	CCNE2 CDK1 RBL1 CCNA2 RBL2 CDKN1B EP300 E2F4	TP53 Regulates Transcription of Cell Cycle Genes
REAC:R-HSA-1538133	8.55030716863e-13	0.333333333333	E2F5 CDK1 RBL1 CCNA2 RBL2 E2F4 CCNE2	G0 and Early G1
REAC:R-HSA-69242	1.78091860841e-12	0.47619047619	E2F5 CCNE2 CDT1 RBL2 CCNA2 CDKN1B CKS1B GMNN SKP2 E2F4	S Phase
REAC:R-HSA-1362300	6.38711351855e-12	0.285714285714	E2F5 CDK1 RBL1 CCNA2 RBL2 E2F4	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
REAC:R-HSA-69202	4.25425933265e-11	0.380952380952	E2F5 CCNE2 RBL2 CCNA2 CDKN1B E2F4 SKP2 CKS1B	Cyclin E associated events during G1/S transition
REAC:R-HSA-69656	5.19536922566e-11	0.380952380952	E2F5 CCNE2 RBL2 CCNA2 CDKN1B E2F4 SKP2 CKS1B	Cyclin A:Cdk2-associated events at S phase entry
REAC:R-HSA-3700989	7.92057635596e-11	0.52380952381	CCNE2 CDK1 CREBBP RBL1 RBL2 CCNA2 CDKN1B CDK5 EP300 CDK5R1 E2F4	Transcriptional Regulation by TP53
KEGG:05203	1.09213950061e-10	0.428571428571	CCNE2 CREBBP RBL1 RBL2 CCNA2 CDKN1B EP300 SKP2 CDK1	Viral carcinogenesis
GO:0000307	2.3162982634e-10	0.380952380952	CCNE2 CKS1B CDK1 CCNA2 CDK5 CDK3 CCNB2 CDK5R1	cyclin-dependent protein kinase holoenzyme complex
WP:WP366	3.48395237492e-10	0.380952380952	E2F5 CREBBP RBL1 RBL2 E2F4 EP300 CCNB2 CDK1	TGF beta signaling pathway
REAC:R-HSA-69205	3.73779575451e-10	0.285714285714	E2F5 CDK1 RBL1 RBL2 E2F4 CDT1	G1/S-Specific Transcription
KEGG:04218	6.23840455123e-10	0.380952380952	E2F5 CDK1 RBL1 RBL2 CCNA2 E2F4 CCNB2 CCNE2	Cellular senescence
CORUM:5118	1.63737564381e-09	0.190476190476	E2F5 EP300 E2F4 RBL2	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
GO:0000278	1.95881391664e-09	0.666666666667	CCNE2 CDK1 GMNN RBL2 CDKN1C PKMYT1 CDKN1B CCNA2 CDT1 CKS1B RBL1 CCNB2 SKP2 CDK3	mitotic cell cycle
WP:WP2446	2.54530612991e-09	0.333333333333	CDK1 CDT1 CCNA2 CDKN1B CCNB2 SKP2 CCNE2	Retinoblastoma gene in cancer
GO:0007049	5.44048255524e-09	0.761904761905	CCNE2 CDK1 GMNN RBL2 CDKN1C PKMYT1 CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 CCNB2 SKP2 CDK5R1 CDK3	cell cycle
REAC:R-HSA-6804114	7.18892511866e-09	0.238095238095	RBL1 EP300 RBL2 E2F4 CDK1	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
GO:0051726	1.07066076471e-08	0.666666666667	CCNE2 CDK1 GMNN RBL2 CDKN1C PKMYT1 CDKN1B CDK5 CDT1 CKS1B RBL1 SKP2 CDK5R1 CDK3	regulation of cell cycle
WP:WP5180	1.22061069123e-08	0.285714285714	E2F5 GMNN RBL2 CDKN1B RBL1 E2F4	DYRK1A involvement regarding cell proliferation in brain development
REAC:R-HSA-212436	3.545549397e-08	0.619047619048	CCNE2 E2F5 CDK1 RBL1 RBL2 CCNA2 CREBBP CDKN1B CDK5 EP300 SKP2 CDK5R1 E2F4	Generic Transcription Pathway
CORUM:1661	8.87775379387e-08	0.142857142857	RBL1 E2F4 CCNA2	E2F4-p107-cyclinA complex
GO:0044770	1.35508476173e-07	0.52380952381	CCNE2 CDK1 RBL1 PKMYT1 RBL2 CCNA2 CDK3 CDT1 CCNB2 SKP2 CDKN1B	cell cycle phase transition
REAC:R-HSA-73857	1.39680661095e-07	0.619047619048	CCNE2 E2F5 CDK1 RBL1 RBL2 CCNA2 CREBBP CDKN1B CDK5 EP300 SKP2 CDK5R1 E2F4	RNA Polymerase II Transcription
GO:1902554	2.25816270887e-07	0.380952380952	CCNE2 CKS1B CDK1 CCNA2 CDK5 CDK3 CCNB2 CDK5R1	serine/threonine protein kinase complex
GO:0044772	5.39578133613e-07	0.47619047619	CCNE2 CDK1 RBL1 PKMYT1 RBL2 CCNA2 CDKN1B CCNB2 SKP2 CDK3	mitotic cell cycle phase transition
KEGG:04068	5.42078831213e-07	0.285714285714	CREBBP RBL2 CDKN1B EP300 CCNB2 SKP2	FoxO signaling pathway
GO:1902911	6.30257675515e-07	0.380952380952	CCNE2 CKS1B CDK1 CCNA2 CDK5 CDK3 CCNB2 CDK5R1	protein kinase complex
REAC:R-HSA-74160	6.61960462644e-07	0.619047619048	CCNE2 E2F5 CDK1 RBL1 RBL2 CCNA2 CREBBP CDKN1B CDK5 EP300 SKP2 CDK5R1 E2F4	Gene expression (Transcription)
CORUM:2975	8.86135714757e-07	0.142857142857	RBL1 E2F4 E2F5	SMAD3-E2F4/5-p107-DP1 complex
CORUM:1471	8.86135714757e-07	0.142857142857	E2F5 RBL2 EP300	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
CORUM:5117	8.86135714757e-07	0.142857142857	E2F5 E2F4 RBL2	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2)
GO:0016538	1.01976927829e-06	0.285714285714	CCNE2 CCNA2 CKS1B CCNB2 CDKN1B CDK5R1	cyclin-dependent protein serine/threonine kinase regulator activity
CORUM:3015	1.77063405387e-06	0.142857142857	CDKN1B SKP2 CKS1B	p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
CORUM:1474	1.77063405387e-06	0.142857142857	RBL1 E2F4 E2F5	SMAD3/4-E2F4/5-p107-DP1 complex
GO:0000082	2.20232985566e-06	0.380952380952	CCNE2 CDK1 RBL1 RBL2 CCNA2 CDKN1B SKP2 CDK3	G1/S transition of mitotic cell cycle
REAC:R-HSA-1362277	3.04903593108e-06	0.190476190476	RBL1 RBL2 E2F4 E2F5	Transcription of E2F targets under negative control by DREAM complex
WP:WP707	3.52016359449e-06	0.238095238095	CCNE2 CCNB2 CDK5 CDK1 CDKN1B	DNA damage response
WP:WP1530	3.52016359449e-06	0.238095238095	CCNE2 CCNB2 CDK5 CDK1 CDKN1B	miRNA regulation of DNA damage response
GO:1990234	4.42618932093e-06	0.571428571429	CCNE2 CDK1 CCNA2 SKP2 CDK5 CDKN1B EP300 CCNB2 CDK3 CREBBP CDK5R1 CKS1B	transferase complex
GO:0044843	5.94209537807e-06	0.380952380952	CCNE2 CDK1 RBL1 RBL2 CCNA2 CDKN1B SKP2 CDK3	cell cycle G1/S phase transition
GO:1903047	5.96890278055e-06	0.52380952381	CCNE2 CDK1 RBL1 PKMYT1 RBL2 CCNA2 CDK3 CDT1 CCNB2 SKP2 CDKN1B	mitotic cell cycle process
REAC:R-HSA-187577	6.10039114537e-06	0.238095238095	CDKN1B CCNA2 CCNE2 SKP2 CKS1B	SCF(Skp2)-mediated degradation of p27/p21
KEGG:05165	6.66005346638e-06	0.333333333333	CREBBP RBL1 CCNA2 RBL2 CDKN1B EP300 CCNE2	Human papillomavirus infection
KEGG:04350	7.38112959935e-06	0.238095238095	CREBBP RBL1 EP300 E2F4 E2F5	TGF-beta signaling pathway
REAC:R-HSA-69478	8.17971429006e-06	0.142857142857	CCNB2 PKMYT1 CDK1	G2/M DNA replication checkpoint
REAC:R-HSA-69273	1.25227510168e-05	0.190476190476	CCNB2 CCNA2 PKMYT1 CDK1	Cyclin A/B1/B2 associated events during G2/M transition
REAC:R-HSA-69052	4.77610545822e-05	0.238095238095	CCNE2 GMNN CCNA2 SKP2 CDT1	Switching of origins to a post-replicative state
REAC:R-HSA-9687139	5.13526282739e-05	0.190476190476	CDKN1B CCNE2 SKP2 CDKN1C	Aberrant regulation of mitotic cell cycle due to RB1 defects
REAC:R-HSA-2173796	5.77179025468e-05	0.190476190476	RBL1 EP300 E2F4 E2F5	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
GO:0022402	6.46372198995e-05	0.571428571429	CCNE2 CDK1 RBL1 PKMYT1 RBL2 CCNA2 CDT1 CDK3 GMNN CCNB2 SKP2 CDKN1B	cell cycle process
REAC:R-HSA-9675126	6.46537410663e-05	0.190476190476	CDKN1B CCNE2 SKP2 CDKN1C	Diseases of mitotic cell cycle
GO:0007346	6.77328763895e-05	0.428571428571	CDK1 GMNN RBL2 CDKN1C PKMYT1 CKS1B RBL1 CDKN1B CDK3	regulation of mitotic cell cycle
CORUM:5542	6.82792716788e-05	0.0952380952381	CCNB2 CDK1	CCNB2-CDC2 complex
CORUM:5160	6.82792716788e-05	0.0952380952381	E2F4 RBL2	E2F4-p130 complex
CORUM:5559	6.82792716788e-05	0.0952380952381	CDK1 CCNA2	CDC2-CCNA2-CDK2 complex
CORUM:5557	6.82792716788e-05	0.0952380952381	CDK1 CCNA2	CDC2-CCNA2 complex
CORUM:6140	6.82792716788e-05	0.0952380952381	GMNN CDT1	Cdt1-Geminin complex
CORUM:5159	6.82792716788e-05	0.0952380952381	RBL1 E2F4	E2F4-p107-cyclinE complex
GO:0005634	8.26438783665e-05	1.0	CCNE2 CKS1B CDK1 CREBBP E2F5 GMNN RBL2 CDKN1C MIDEAS PKMYT1 CDKN1B CCNA2 CDK5 CDT1 E2F4 RBL1 CCNB2 EP300 SKP2 CDK5R1 CDK3	nucleus
KEGG:05200	0.000110854981256	0.333333333333	CCNE2 CREBBP CCNA2 CDKN1B EP300 SKP2 CKS1B	Pathways in cancer
GO:0061695	0.000120229606814	0.380952380952	CCNE2 CKS1B CDK1 CCNA2 CDK5 CDK3 CCNB2 CDK5R1	transferase complex, transferring phosphorus-containing groups
GO:0019887	0.000151770138732	0.333333333333	CCNE2 CDK5R1 CCNA2 CDKN1C CDKN1B CCNB2 CKS1B	protein kinase regulator activity
REAC:R-HSA-69239	0.000193275000633	0.238095238095	CCNE2 GMNN CCNA2 SKP2 CDT1	Synthesis of DNA
CORUM:1473	0.000204660259961	0.0952380952381	E2F5 RBL2	E2F5-RB2-DP1 complex
CORUM:571	0.000204660259961	0.0952380952381	EP300 CREBBP	p300-CBP-p270 complex
CORUM:6954	0.000204660259961	0.0952380952381	GMNN CDT1	Idas-Geminin-Cdt1 complex
CORUM:4	0.000204660259961	0.0952380952381	EP300 CREBBP	Multisubunit ACTR coactivator complex
CORUM:5144	0.000204660259961	0.0952380952381	RBL1 CCNA2	E2F1-p107-cyclinA complex
REAC:R-HSA-2173793	0.000222733915651	0.190476190476	RBL1 EP300 E2F4 E2F5	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REAC:R-HSA-6804116	0.000232216382943	0.142857142857	CCNE2 CDKN1B CCNA2	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
WP:WP45	0.000232480239526	0.190476190476	CDKN1B CCNE2 CDKN1C CDK1	G1 to S cell cycle control
GO:0045786	0.000244111052652	0.380952380952	CDK1 RBL1 RBL2 PKMYT1 CDKN1C CDT1 CDKN1B GMNN	negative regulation of cell cycle
KEGG:04914	0.000300978969241	0.190476190476	CCNB2 CCNA2 PKMYT1 CDK1	Progesterone-mediated oocyte maturation
GO:0005654	0.000352027648697	0.857142857143	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 PKMYT1 MIDEAS CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 EP300 SKP2 CDK5R1 E2F4	nucleoplasm
KEGG:05222	0.000364061664052	0.190476190476	CDKN1B CCNE2 SKP2 CKS1B	Small cell lung cancer
REAC:R-HSA-156711	0.00036875287941	0.142857142857	CCNB2 PKMYT1 EP300	Polo-like kinase mediated events
CORUM:310	0.000408965737855	0.0952380952381	CCNB2 CDK1	Cell cycle kinase complex CDC2
KEGG:05166	0.000434855017695	0.238095238095	CCNE2 CCNB2 EP300 CREBBP CCNA2	Human T-cell leukemia virus 1 infection
KEGG:05215	0.000436429921007	0.190476190476	CCNE2 EP300 CDKN1B CREBBP	Prostate cancer
GO:0019207	0.000443427241831	0.333333333333	CCNE2 CDK5R1 CCNA2 CDKN1C CDKN1B CCNB2 CKS1B	kinase regulator activity
REAC:R-HSA-9614085	0.000467239238708	0.190476190476	EP300 RBL2 CDKN1B CREBBP	FOXO-mediated transcription
REAC:R-HSA-9659787	0.000550085437963	0.142857142857	CCNE2 CDKN1C CDKN1B	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
REAC:R-HSA-9661069	0.000550085437963	0.142857142857	CCNE2 CDKN1C CDKN1B	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
REAC:R-HSA-69620	0.000626834201201	0.285714285714	CCNE2 CCNA2 PKMYT1 CDKN1B CCNB2 CDK1	Cell Cycle Checkpoints
REAC:R-HSA-5633007	0.000649568122157	0.238095238095	CCNA2 EP300 CDK1 CDK5 CDK5R1	Regulation of TP53 Activity
REAC:R-HSA-9768919	0.00065949271837	0.142857142857	CDK5 CREBBP CDK5R1	NPAS4 regulates expression of target genes
CORUM:3036	0.000681018805949	0.0952380952381	SKP2 CKS1B	Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)
CORUM:2638	0.000681018805949	0.0952380952381	EP300 CREBBP	HES1 promoter corepressor complex
GO:1902494	0.000771787659786	0.619047619048	CCNE2 CDK1 MIDEAS CCNA2 CREBBP CDK5 CDKN1B EP300 CCNB2 CDK3 SKP2 CDK5R1 CKS1B	catalytic complex
KEGG:04114	0.000775177044629	0.190476190476	CCNE2 CCNB2 PKMYT1 CDK1	Oocyte meiosis
WP:WP4658	0.000872791785336	0.190476190476	CDKN1B CCNE2 CDKN1C CKS1B	Small cell lung cancer
GO:0005667	0.000943754776813	0.380952380952	E2F5 CREBBP GMNN MIDEAS RBL2 E2F4 RBL1 EP300	transcription regulator complex
CORUM:5596	0.0010206428919	0.0952380952381	E2F4 RBL2	LINC complex, quiescent cells
CORUM:6444	0.0010206428919	0.0952380952381	RBL1 RBL2	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex
GO:1904029	0.00103568301962	0.238095238095	CDKN1B CCNE2 PKMYT1 CDK5R1 CDKN1C	regulation of cyclin-dependent protein kinase activity
GO:0031981	0.00105967192723	0.857142857143	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 PKMYT1 MIDEAS CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 EP300 SKP2 CDK5R1 E2F4	nuclear lumen
REAC:R-HSA-69306	0.00126201955342	0.238095238095	CCNE2 GMNN CCNA2 SKP2 CDT1	DNA Replication
CORUM:570	0.00142766174991	0.0952380952381	EP300 CREBBP	p300-CBP-p270-SWI/SNF complex
WP:000000	0.0017733334666	0.904761904762	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 CDKN1C PKMYT1 CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 CCNB2 EP300 SKP2 CDK5R1 E2F4	WIKIPATHWAYS
REAC:R-HSA-170145	0.00188917163041	0.0952380952381	CDK1 CCNA2	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
REAC:R-HSA-69275	0.00189087036823	0.238095238095	CCNB2 EP300 CCNA2 PKMYT1 CDK1	G2/M Transition
REAC:R-HSA-453274	0.00199051894549	0.238095238095	CCNB2 EP300 CCNA2 PKMYT1 CDK1	Mitotic G2-G2/M phases
REAC:R-HSA-170834	0.0020797735601	0.190476190476	RBL1 EP300 E2F4 E2F5	Signaling by TGF-beta Receptor Complex
HP:0001042	0.00234100360042	0.0952380952381	EP300 CREBBP	High axial triradius
HP:0034227	0.00234100360042	0.0952380952381	EP300 CREBBP	Aortic isthmus hypoplasia
HP:0008107	0.00234100360042	0.0952380952381	EP300 CREBBP	Plantar crease between first and second toes
HP:0005895	0.00234100360042	0.0952380952381	EP300 CREBBP	Radial deviation of thumb terminal phalanx
REAC:R-HSA-9634815	0.00262331235357	0.142857142857	CDK5 CREBBP CDK5R1	Transcriptional Regulation by NPAS4
HP:0003042	0.00305099476005	0.190476190476	GMNN EP300 CREBBP CDT1	Elbow dislocation
CORUM:1005	0.00305132938631	0.0952380952381	CDK1 CCNA2	RC complex during G2/M-phase of cell cycle
KEGG:05206	0.00310510287641	0.190476190476	CCNE2 EP300 CDKN1B CREBBP	MicroRNAs in cancer
KEGG:05161	0.00310510287641	0.190476190476	CCNE2 EP300 CREBBP CCNA2	Hepatitis B
WP:WP3878	0.00323277962572	0.142857142857	CDK5 CDK1 CDK5R1	ATM signaling in development and disease
REAC:R-HSA-9031628	0.00395714876545	0.142857142857	EP300 CDK5R1 CDK5	NGF-stimulated transcription
REAC:R-HSA-9006936	0.00491016220686	0.190476190476	RBL1 EP300 E2F4 E2F5	Signaling by TGFB family members
HP:0030310	0.00499206865234	0.190476190476	GMNN EP300 CREBBP CDT1	Upper extremity joint dislocation
GO:0031323	0.0054108462452	0.857142857143	CCNE2 E2F5 CDK1 GMNN RBL2 CDKN1C MIDEAS PKMYT1 CREBBP CCNA2 CDK5 CDT1 E2F4 RBL1 EP300 CDKN1B CDK5R1 CDK3	regulation of cellular metabolic process
KEGG:04115	0.00591582367894	0.142857142857	CCNB2 CDK1 CCNE2	p53 signaling pathway
REAC:R-HSA-3134973	0.00628632743953	0.0952380952381	EP300 CREBBP	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
REAC:R-HSA-9032845	0.00628632743953	0.0952380952381	CDK5R1 CDK5	Activated NTRK2 signals through CDK5
KEGG:05169	0.0066422860675	0.190476190476	CCNE2 CCNA2 SKP2 CDKN1B	Epstein-Barr virus infection
HP:0006200	0.00701692319865	0.0952380952381	EP300 CREBBP	Widened distal phalanges
HP:0005363	0.00701692319865	0.0952380952381	EP300 CREBBP	Humoral immunodeficiency
HP:0000756	0.00701692319865	0.0952380952381	EP300 CREBBP	Agoraphobia
HP:5200232	0.00701692319865	0.0952380952381	EP300 CREBBP	Phobia
HP:0005322	0.00701692319865	0.0952380952381	EP300 CREBBP	Prominent nasal septum
HP:0008752	0.00701692319865	0.0952380952381	EP300 CREBBP	Laryngeal cartilage malformation
HP:0010785	0.00737658276448	0.190476190476	CREBBP EP300 CDKN1C CDKN1B	Gonadal neoplasm
WP:WP5158	0.00969614906734	0.142857142857	EP300 CDK1 CREBBP	Urotensin II mediated signaling pathway
HP:0003045	0.0105142945578	0.190476190476	GMNN EP300 CREBBP CDT1	Abnormal patella morphology
CORUM:5614	0.0115049703489	0.0952380952381	RBL1 RBL2	Emerin complex 32
REAC:R-HSA-2980767	0.013178416153	0.0952380952381	CCNB2 CDK1	Activation of NIMA Kinases NEK9, NEK6, NEK7
REAC:R-HSA-1234158	0.013178416153	0.0952380952381	EP300 CREBBP	Regulation of gene expression by Hypoxia-inducible Factor
HP:0031207	0.0140216824407	0.0952380952381	EP300 CREBBP	Hepatic hemangioma
HP:0410266	0.0140216824407	0.0952380952381	EP300 CREBBP	Visceral hemangioma
HP:0001128	0.0140216824407	0.0952380952381	EP300 CREBBP	Trichiasis
HP:0010775	0.0140216824407	0.0952380952381	EP300 CREBBP	Vascular ring
HP:0011087	0.0140216824407	0.0952380952381	EP300 CREBBP	Talon cusp
GO:1901988	0.0152086559394	0.285714285714	CDK1 RBL1 PKMYT1 RBL2 CDKN1B CDT1	negative regulation of cell cycle phase transition
GO:1901987	0.015531536336	0.333333333333	CDK1 CDT1 PKMYT1 RBL2 CDKN1B RBL1 CDK3	regulation of cell cycle phase transition
WP:WP53	0.0158065007671	0.0952380952381	RBL1 RBL2	ID signaling pathway
REAC:R-HSA-9818028	0.0175559950179	0.0952380952381	EP300 CREBBP	NFE2L2 regulates pentose phosphate pathway genes
HP:0005930	0.0190032105099	0.238095238095	CREBBP GMNN EP300 CDKN1C CDT1	Abnormal epiphysis morphology
REAC:R-HSA-198725	0.0193907029168	0.142857142857	EP300 CDK5R1 CDK5	Nuclear Events (kinase and transcription factor activation)
GO:0000086	0.0194642623679	0.238095238095	CCNA2 CDK1 SKP2 PKMYT1 CDK3	G2/M transition of mitotic cell cycle
HP:0000787	0.0196103262085	0.190476190476	CREBBP EP300 CDKN1C CDKN1B	Nephrolithiasis
KEGG:04066	0.0215622748439	0.142857142857	EP300 CDKN1B CREBBP	HIF-1 signaling pathway
GO:0019222	0.0217517881861	0.857142857143	CCNE2 E2F5 CDK1 GMNN RBL2 CDKN1C MIDEAS PKMYT1 CREBBP CCNA2 CDK5 CDT1 E2F4 RBL1 EP300 CDKN1B CDK5R1 CDK3	regulation of metabolic process
HP:0030421	0.023349216204	0.0952380952381	EP300 CREBBP	Epididymal neoplasm
HP:0033777	0.023349216204	0.0952380952381	EP300 CREBBP	Supernumerary cusp
HP:0009715	0.023349216204	0.0952380952381	EP300 CREBBP	Papillary cystadenoma of the epididymis
HP:0000327	0.0241861097206	0.190476190476	GMNN EP300 CREBBP CDT1	Hypoplasia of the maxilla
WP:WP4970	0.0250814115019	0.0952380952381	CDKN1C CDKN1B	Galanin receptor pathway
GO:0003682	0.0259929133911	0.333333333333	CREBBP RBL1 GMNN RBL2 E2F4 CDT1 EP300	chromatin binding
REAC:R-HSA-8866907	0.0281661174121	0.0952380952381	EP300 CREBBP	Activation of the TFAP2 (AP-2) family of transcription factors
REAC:R-HSA-9617629	0.0281661174121	0.0952380952381	EP300 CREBBP	Regulation of FOXO transcriptional activity by acetylation
GO:0044839	0.0301509000987	0.238095238095	CCNA2 CDK1 SKP2 PKMYT1 CDK3	cell cycle G2/M phase transition
GO:0043549	0.0305894784382	0.333333333333	CDK5R1 RBL1 RBL2 PKMYT1 CDKN1C CDKN1B CCNE2	regulation of kinase activity
HP:0002858	0.0313271739921	0.142857142857	EP300 CDKN1B CREBBP	Meningioma
REAC:R-HSA-69563	0.0322715766076	0.142857142857	CCNE2 CDKN1B CCNA2	p53-Dependent G1 DNA Damage Response
REAC:R-HSA-69580	0.0322715766076	0.142857142857	CCNE2 CDKN1B CCNA2	p53-Dependent G1/S DNA damage checkpoint
WP:WP2431	0.0340503948662	0.142857142857	E2F5 CDK1 CDKN1B	Spinal cord injury
REAC:R-HSA-8941856	0.0343954281992	0.0952380952381	EP300 CREBBP	RUNX3 regulates NOTCH signaling
REAC:R-HSA-2514853	0.0343954281992	0.0952380952381	CCNB2 CDK1	Condensation of Prometaphase Chromosomes
REAC:R-HSA-210744	0.0343954281992	0.0952380952381	EP300 CREBBP	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
HP:0100852	0.0349934705793	0.0952380952381	EP300 CREBBP	Abnormal fear-induced behavior
HP:0004411	0.0349934705793	0.0952380952381	EP300 CREBBP	Deviated nasal septum
HP:0008523	0.0349934705793	0.0952380952381	EP300 CDKN1C	Posterior helix pit
HP:0002700	0.0349934705793	0.0952380952381	EP300 CREBBP	Large foramen magnum
REAC:R-HSA-69615	0.0353787719881	0.142857142857	CCNE2 CDKN1B CCNA2	G1/S DNA Damage Checkpoints
WP:WP3640	0.0364523199885	0.0952380952381	SKP2 CDKN1B	Imatinib and chronic myeloid leukemia
HP:0010787	0.0367394277344	0.190476190476	CREBBP EP300 CDKN1C CDKN1B	Genital neoplasm
REAC:R-HSA-2559586	0.0370029498433	0.142857142857	CCNE2 CDKN1B CCNA2	DNA Damage/Telomere Stress Induced Senescence
GO:0010948	0.0377721065719	0.285714285714	CDK1 RBL1 PKMYT1 RBL2 CDKN1B CDT1	negative regulation of cell cycle process
GO:0070013	0.0398416860827	0.857142857143	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 PKMYT1 MIDEAS CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 EP300 SKP2 CDK5R1 E2F4	intracellular organelle lumen
GO:0043233	0.0398416860827	0.857142857143	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 PKMYT1 MIDEAS CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 EP300 SKP2 CDK5R1 E2F4	organelle lumen
GO:0031974	0.0398416860827	0.857142857143	CCNE2 E2F5 CDK1 CREBBP GMNN RBL2 PKMYT1 MIDEAS CDKN1B CCNA2 CDK5 CDT1 CKS1B RBL1 EP300 SKP2 CDK5R1 E2F4	membrane-enclosed lumen
HP:0000294	0.0402087685285	0.190476190476	EP300 CDK5 CREBBP RBL2	Low anterior hairline
WP:WP3657	0.0407055461977	0.0952380952381	EP300 CREBBP	Hematopoietic stem cell gene regulation by GABP alpha beta complex
REAC:R-HSA-68949	0.0421654372186	0.142857142857	CDT1 SKP2 CCNA2	Orc1 removal from chromatin
WP:WP5322	0.0450847564917	0.142857142857	CCNB2 CDK1 CDKN1B	CKAP4 signaling pathway map
HP:0000326	0.0452012273131	0.190476190476	GMNN EP300 CREBBP CDT1	Abnormal maxilla morphology
HPA:0620221	0.0459751188163	0.761904761905	CCNE2 CDK1 RBL1 RBL2 CDKN1C MIDEAS CREBBP CCNA2 CDK5 CDT1 CKS1B GMNN CCNB2 EP300 SKP2 CDKN1B	vagina; squamous epithelial cells[>=Low]
HPA:0620000	0.0459751188163	0.761904761905	CCNE2 CDK1 RBL1 RBL2 CDKN1C MIDEAS CREBBP CCNA2 CDK5 CDT1 CKS1B GMNN CCNB2 EP300 SKP2 CDKN1B	vagina
REAC:R-HSA-162658	0.0486944895379	0.0952380952381	CCNB2 CDK1	Golgi Cisternae Pericentriolar Stack Reorganization
REAC:R-HSA-3371568	0.0486944895379	0.0952380952381	EP300 CREBBP	Attenuation phase
HP:0030434	0.0489484028541	0.0952380952381	EP300 CREBBP	Pilomatrixoma
HP:0011335	0.0489484028541	0.0952380952381	EP300 CREBBP	Frontal hirsutism
WP:WP2882	0.0496114568649	0.190476190476	CDKN1B EP300 CDKN1C CDK1	Nuclear receptors meta pathway
CORUM:5319	0.0498916638157	0.047619047619	CKS1B	CDH1-CKS1B complex
CORUM:1656	0.0498916638157	0.047619047619	CDKN1B	p27-cyclinE-CDK2 complex
CORUM:5556	0.0498916638157	0.047619047619	CCNA2	CDK2-CCNA2 complex
CORUM:5543	0.0498916638157	0.047619047619	CDK1	CCNB1-CDC2 complex
CORUM:5198	0.0498916638157	0.047619047619	CREBBP	CBP-RARA-RXRA-DNA complex, ligand stimulated
CORUM:2628	0.0498916638157	0.047619047619	CDK3	CCNC-CDK3 complex
CORUM:5320	0.0498916638157	0.047619047619	SKP2	CDH1-SKP2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CDKN1B	CCNA2	1.0	0.124	structurally_consistent (dimer)
SKP2	CKS1B	1.0	0.138	structurally_consistent (dimer)
CCNB1	CKS1B	1.0	0.22	structurally_consistent (dimer)
CCNB1	CDKN1B	1.0	0.26236
SKP2	CCNA2	1.0	0.284	mutually_exclusive (P11802) structurally_consistent (dimer)
CCNA2	CKS1B	1.0	0.222
RBL2	CCNA2	1.0	0.118
CCNB1	CKS2	1.0	0.152
PKMYT1	CCNB2	1.0	0.214	structurally_consistent (dimer)
CCNA2	CDK2	1.0	0.224	structurally_consistent (dimer)
CDKN1B	CKS1B	1.0	0.072
CCNA2	GMNN	1.0	0.358
RBL1	CDK2	1.0	0.184	structurally_consistent (dimer)
CDKN1B	CCNE1	1.0	0.102
RBL2	CDK2	1.0	0.126	mutually_exclusive (P24385) structurally_consistent (dimer)
CCNB2	CKS2	1.0	0.134
RBL1	CCNA2	1.0	0.296	structurally_consistent (dimer)
CDKN1B	CKS2	1.0	0.036
CDK1	CKS2	1.0	0.23	structurally_consistent (dimer)
CDT1	CCNA2	1.0	0.128
CDKN1B	CDK1	1.0	0.158	structurally_consistent (P20248)
CKS1B	CDK2	0.999	0.112	structurally_consistent (dimer)
CDT1	GMNN	0.999	0.204
CCNB1	CDK2	0.999	0.161	structurally_consistent (dimer)
CDK1	CCNA2	0.999	0.258	structurally_consistent (dimer)
CDK2	CCNE2	0.999		structurally_consistent (dimer)
CCNA2	CDKN1C	0.999	0.096
CCNB2	CDKN1B	0.999	0.182
SKP2	CDK2	0.999	0.278
CDKN1B	CDK2	0.999	0.1424	structurally_consistent (P20248) structurally_consistent (dimer)
CCNB2	CCNB1	0.999	0.274
CCNA2	CCNE2	0.999
CDKN1B	CDKN1C	0.999	0.158	mutually_exclusive (P30281)
CDK5	CDK5R1	0.999		structurally_consistent (dimer)
CKS2	CCNA2	0.999	0.206	structurally_consistent (dimer)
CDK1	CKS1B	0.999	0.452	structurally_consistent (dimer)
CDKN1B	CDK5	0.999	0.114
CKS2	CDK2	0.999	0.062	structurally_consistent (dimer)
PKMYT1	CCNB1	0.999	0.276	mutually_exclusive (P61024) structurally_consistent (dimer)
CCNB2	CKS1B	0.999	0.22
CCNE1	CCNE2	0.999
EP300	CREBBP	0.999	0.476
CKS1B	CDKN1C	0.999	0.068
CCNB1	CDK1	0.999	0.3
CCNB1	CCNE1	0.998	0.102
SKP2	CDKN1C	0.998	0.086
CKS2	CKS1B	0.998	0.584	structurally_consistent (dimer)
CCNA2	CCNE1	0.998	0.126	mutually_exclusive (P24941)
CDKN1B	SKP2	0.998	0.174	mutually_exclusive (P11802)
CDK2	CDKN1C	0.998	0.172	structurally_consistent (dimer)
CKS2	SKP2	0.998	0.098
PKMYT1	CCNA2	0.998	0.12
GMNN	CKS1B	0.998	0.138
CKS1B	CDK3	0.998		structurally_consistent (dimer)
CCNB2	CDK1	0.998	0.35
SKP2	CDT1	0.998	0.21
CCNB1	CCNA2	0.998	0.348	structurally_consistent (dimer)
CDK2	CCNE1	0.998	0.15	structurally_consistent (dimer)
PKMYT1	CDKN1B	0.998	0.08
CDK1	CDK2	0.998	0.288	mutually_exclusive (P20248)
CDKN1B	CCNE2	0.997
CKS2	CDKN1C	0.997	0.026
CDK3	CDK2	0.997		structurally_consistent (dimer)
SKP2	GMNN	0.997	0.27
CREBBP	CDK2	0.997	0.134
CCNA2	CDK3	0.996
RBL2	RBL1	0.996	0.118
CCNB2	CCNA2	0.996	0.28	structurally_consistent (dimer)
CDT1	CDK2	0.996	0.256
CREBBP	CCNA2	0.996	0.236473684211
SKP2	CDK3	0.996
CDK1	CDKN1C	0.996	0.298
PKMYT1	CKS1B	0.996	0.064	structurally_consistent (dimer)
GMNN	CDK2	0.996	0.193555555556
CDK1	SKP2	0.996	0.372
EP300	CCNA2	0.995	0.266809384164
MIDEAS	CCNA2	0.995	0.06
CDT1	CKS1B	0.995	0.19
CKS2	CDK3	0.995		structurally_consistent (dimer)
CCNB1	SKP2	0.994	0.354	mutually_exclusive (P20248)
CDK2	CDK5	0.994	0.158
PCNA	CCNE2	0.994
CCNB2	SKP2	0.994	0.322	mutually_exclusive (P20248)
PKMYT1	CDK1	0.993	0.206885714286	structurally_consistent (dimer)
CCNB1	CCNE2	0.992
CDKN1B	CDT1	0.992	0.066
CKS2	CCNE2	0.992
PCNA	CCNE1	0.992	0.124
CKS2	CCNE1	0.992	0.126
CDKN1B	GMNN	0.992	0.148
CDK3	CCNE2	0.991		structurally_consistent (dimer)
CCNB2	CDK2	0.991	0.214	structurally_consistent (dimer)
CDKN1B	CDK3	0.99		structurally_consistent (dimer)
RBL2	CDKN1C	0.989	0.052
MIDEAS	CDKN1C	0.987	0.06
RBL2	CDKN1B	0.987	0.147076923077
CCNB1	CDK3	0.984
CDK2	CDK5R1	0.984		structurally_consistent (dimer)
PKMYT1	CKS2	0.984	0.056
CDKN1B	MIDEAS	0.983	0.094
CDK3	CDKN1C	0.982		structurally_consistent (dimer)
CDK5	CDKN1C	0.982	0.132
CDK3	CCNE1	0.982
CKS1B	CCNE2	0.981		structurally_consistent (dimer)
SKP2	CCNE2	0.98
CKS1B	CCNE1	0.979	0.084	structurally_consistent (dimer)
RBL2	CDK1	0.979	0.230961538462
CDT1	CDK3	0.977		mutually_exclusive (P06493) structurally_consistent (dimer)
SKP2	CCNE1	0.977	0.158
CDK1	GMNN	0.976	0.142
E2F4	GMNN	0.974	0.072
CCNB1	CDK5	0.974	0.066
E2F4	E2F5	0.974
CKS2	GMNN	0.974	0.084
CCNA2	PCNA	0.973	0.310958333333
CCNB1	CDKN1C	0.973	0.12	structurally_consistent (dimer)
PKMYT1	SKP2	0.969	0.184	mutually_exclusive (P61024)
EP300	CDK2	0.967	0.144578947368
GMNN	CDK3	0.967
MIDEAS	CDK2	0.966	0.038
CDK5	CCNE2	0.965
E2F5	CDK2	0.965
E2F4	CDK2	0.962	0.284
GMNN	E2F5	0.961
E2F4	CCNA2	0.96	0.138
PKMYT1	CDKN1C	0.959	0.182
PKMYT1	CDT1	0.958	0.116	mutually_exclusive (P14635)
CDK1	CCNE1	0.955	0.254946428571
CDK1	CDT1	0.954	0.386741935484	mutually_exclusive (Q00526) structurally_consistent (dimer)
RBL2	CKS2	0.953	0.046	mutually_exclusive (P24941)
CDK2	PCNA	0.951	0.414	structurally_consistent (dimer)
RBL2	CCNB1	0.95	0.251449636552	mutually_exclusive (P24941)
RBL2	CKS1B	0.949	0.052	mutually_exclusive (P24941)
CCNB2	CCNE1	0.949	0.114
RBL2	SKP2	0.947	0.098
CCNB2	CCNE2	0.938
MIDEAS	SKP2	0.937	0.056
CDK1	CCNE2	0.936
RBL1	CCNE1	0.934	0.15	mutually_exclusive (P24941)
MIDEAS	CKS1B	0.932	0.012
CKS2	CDT1	0.93	0.088	mutually_exclusive (P06493)
CCNA2	CDK5	0.93	0.237875
RBL2	CCNE1	0.93	0.09
GMNN	CDKN1C	0.92	0.126
CCNE2	CDKN1C	0.92
CDK5	CCNE1	0.916	0.176
RBL1	CCNE2	0.914		mutually_exclusive (P24941)
RBL2	CCNE2	0.901
EP300	RBL1	0.877	0.323130434783
CCNB1	PCNA	0.863	0.19	structurally_consistent (dimer)
GMNN	CCNE1	0.855	0.099
CCNB2	CDKN1C	0.851	0.118	structurally_consistent (dimer)
RBL2	CREBBP	0.846	0.362
PKMYT1	CDK2	0.835	0.184	mutually_exclusive (O95067)
RBL1	CREBBP	0.828	0.307536384977
RBL1	CKS1B	0.798	0.112
RBL1	CKS2	0.798	0.142	structurally_consistent (P20248)
RBL2	CDK5	0.793	0.11	mutually_exclusive (P24385)
RBL1	SKP2	0.784	0.136
RBL1	CDKN1B	0.781	0.076
CDT1	CDKN1C	0.773	0.048	mutually_exclusive (P14635)
CDT1	CCNE1	0.771	0.136
MIDEAS	GMNN	0.77	0.024
CKS1B	E2F5	0.763
RBL2	CDK3	0.761
CCNA2	E2F5	0.757
E2F4	CDK1	0.752	0.286385542169
CKS2	MIDEAS	0.749	0.012
CKS2	E2F5	0.746
RBL1	CDKN1C	0.738	0.182
PKMYT1	GMNN	0.73	0.14
E2F4	SKP2	0.702	0.302
RBL1	CDK3	0.702
E2F4	CKS1B	0.702	0.032
CDK1	PCNA	0.69	0.434	structurally_consistent (Q9H211)
PCNA	CDK5	0.685	0.126142857143
E2F4	CKS2	0.681	0.102
CDK3	E2F5	0.675
RBL2	PCNA	0.65	0.19	structurally_consistent (P30279)
CCNB2	CDK3	0.646
RBL1	GMNN	0.638	0.13
CCNB1	E2F5	0.634
E2F4	CDKN1C	0.634	0.074
RBL2	GMNN	0.625	0.094
CCNB1	CDT1	0.621	0.338	mutually_exclusive (P12004) structurally_consistent (dimer)
CKS1B	CDK5	0.597	0.046
E2F4	CDT1	0.592	0.164
PCNA	CDKN1C	0.59	0.098
E2F4	CDKN1B	0.587	0.178
RBL2	CDT1	0.572	0.062
RBL1	CDT1	0.572	0.134
PKMYT1	MIDEAS	0.541	0.0384117647059
E2F4	RBL1	0.526	0.154
E2F4	RBL2	0.524	0.09	structurally_consistent (dimer)
CKS2	CDK5	0.509	0.022
EP300	GMNN	0.5	0.343443566096
EP300	RBL2	0.482	0.226
CDK1	MIDEAS	0.466	0.0484553571429
E2F5	CCNE1	0.455
CDKN1B	CREBBP	0.431	0.388
E2F4	CCNB1	0.416	0.164
CCNE1	CDKN1C	0.413	0.056
RBL2	E2F5	0.404		structurally_consistent (dimer)
CDK1	CREBBP	0.404	0.222
MIDEAS	CDT1	0.396	0.072
E2F5	CCNE2	0.384
E2F4	CCNE2	0.384
RBL1	E2F5	0.384
CREBBP	CDKN1C	0.367	0.198
GMNN	CCNE2	0.367
CCNB2	GMNN	0.367	0.192
E2F4	CCNE1	0.362	0.124
CCNB2	CDK5	0.36	0.142
CCNB1	GMNN	0.358	0.246
E2F4	CDK3	0.325
CDK1	CDK3	0.32		structurally_consistent (dimer)
CDK3	CDK5	0.318
CDKN1B	PCNA	0.308	0.148	structurally_consistent (P30279)
CCNB2	CDT1	0.291	0.208695652174
CCNB2	E2F5	0.288
CDT1	CCNE2	0.281
E2F5	PCNA	0.274
CREBBP	CDK3	0.266
EP300	CDKN1C	0.264	0.088
RBL1	CCNB1	0.258	0.224	mutually_exclusive (P24941)
CKS1B	PCNA	0.254	0.114	structurally_consistent (P24941)
SKP2	E2F5	0.251
EP300	CCNE2	0.242
MIDEAS	CCNE1	0.232	0.152
E2F4	PCNA	0.229	0.228
EP300	CDK3	0.217
E2F4	CCNB2	0.214	0.17
EP300	CCNE1	0.213	0.218
EP300	CCNB2	0.208	0.232
PKMYT1	CDK3	0.207		mutually_exclusive (P06493)
RBL1	CDK1	0.193	0.26446031746
RBL2	CCNB2	0.19	0.088	mutually_exclusive (P24941)
E2F5	CDKN1C	0.188
CDKN1B	E2F5	0.188
MIDEAS	CREBBP	0.185	0.132
EP300	MIDEAS	0.178	0.258
EP300	CKS1B	0.177	0.022
CREBBP	GMNN	0.164	0.204
RBL1	PKMYT1	0.16	0.178
EP300	CKS2	0.16	0.024
E2F4	CDK5	0.159	0.194
RBL1	CCNB2	0.158	0.314
PKMYT1	CREBBP	0.15	0.146
CDK1	CDK5	0.145	0.07
PKMYT1	CCNE2	0.143		mutually_exclusive (P61024)
CDT1	E2F5	0.143
CDT1	CREBBP	0.143	0.248
RBL2	MIDEAS	0.143	0.112
RBL1	MIDEAS	0.143	0.064
EP300	CDT1	0.143	0.26
EP300	CDKN1B	0.141	0.362
CREBBP	CCNE2	0.141
CREBBP	CCNE1	0.136	0.37
E2F5	CDK5	0.133
PKMYT1	CCNE1	0.124	0.106	mutually_exclusive (P61024)
EP300	SKP2	0.12	0.280075471698
CREBBP	CKS1B	0.12	0.048
CKS2	CREBBP	0.12	0.016
CDK1	E2F5	0.118
RBL2	PKMYT1	0.114	0.062
CKS2	PCNA	0.112	0.062	structurally_consistent (P24941)
SKP2	CREBBP	0.111	0.260784313725
RBL1	CDK5	0.097	0.188
EP300	CDK1	0.092	0.257333333333
MIDEAS	CDK5	0.076	0.006
E2F4	PKMYT1	0.074	0.09
CCNB2	CREBBP	0.074	0.376
SKP2	PCNA	0.067	0.186
CREBBP	CDK5	0.067	0.046
EP300	PKMYT1	0.066	0.154
MIDEAS	CCNE2	0.063
CDT1	CDK5	0.063	0.124
MIDEAS	CDK3	0.06
CDK3	CDK5R1	0.055
SKP2	CDK5	0.05	0.144
CCNB1	CREBBP	0.048	0.148
E2F4	EP300	0.046	0.212
E2F4	CREBBP	0.046	0.294
CREBBP	E2F5	0.043
CCNB1	CDK5R1	0.043
CDKN1B	CDK5R1	0.043		mutually_exclusive (P24941)
EP300	E2F5	0.042
E2F4	MIDEAS	0.042	0.088
GMNN	CDK5	0.039	0.15
EP300	CCNB1	0.036	0.09
RBL1	PCNA	0.034	0.274
CDK3	PCNA	0.03
CCNB1	MIDEAS	0.028	0.06
CREBBP	PCNA	0.024	0.262
PKMYT1	CDK5	0.019	0.104
CCNB2	PCNA	0.018	0.218
CDK1	CDK5R1	0.016
PKMYT1	PCNA	0.014	0.26
MIDEAS	PCNA	0.013	0.064
EP300	CDK5	0.011	0.098
CDT1	PCNA	0.01	0.206	structurally_consistent (dimer)
EP300	PCNA	0.007	0.286
CCNB2	MIDEAS	0.006	0.052
PCNA	CDK5R1	0.004
GMNN	PCNA	0.002	0.178

Related Complexes

Genename	Complexes
PKMYT1	huMAP3_00736.1 huMAP3_01356.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1
CDK3	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
SKP2	huMAP3_01026.1 huMAP3_04611.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14632.1 huMAP3_14722.1
GMNN	huMAP3_02716.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNB1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
E2F4	huMAP3_00125.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1
CDKN1C	huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CKS1B	huMAP3_03425.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10328.1 huMAP3_10449.1 huMAP3_14134.1 huMAP3_14722.1
PCNA	huMAP3_03604.1 huMAP3_05320.1 huMAP3_05530.1 huMAP3_06587.1 huMAP3_10449.1 huMAP3_11068.1 huMAP3_14546.1 huMAP3_14722.1
RBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_03477.1 huMAP3_05269.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDK2	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNE1	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
MIDEAS	huMAP3_01026.1 huMAP3_01287.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_06587.1 huMAP3_07709.1 huMAP3_08377.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09319.1 huMAP3_09513.1 huMAP3_10311.1 huMAP3_10449.1 huMAP3_14722.1
E2F5	huMAP3_03477.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_13863.1 huMAP3_14722.1
CDT1	huMAP3_01026.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_14722.1
CDKN1B	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CREBBP	huMAP3_01026.1 huMAP3_02340.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK5R1	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_15344.1
CCNB2	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_14722.1
CKS2	huMAP3_01026.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
RBL2	huMAP3_00487.1 huMAP3_03477.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12923.1 huMAP3_14722.1
CCNA2	huMAP3_01026.1 huMAP3_05269.1 huMAP3_06587.1 huMAP3_07430.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_14722.1
EP300	huMAP3_00314.1 huMAP3_01026.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CDK5	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06311.1 huMAP3_06587.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_11987.1 huMAP3_14722.1 huMAP3_15344.1
CCNE2	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06587.1

Complex Portal: CPX-19796