List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_06607.1

Confidence: Very High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RAB12	Ras-related protein Rab-12	5	UniProt   NCBI
RAB34	Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats)	5	UniProt   NCBI
USP25	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)	5	UniProt   NCBI
RAB6A	Ras-related protein Rab-6A (Rab-6)	5	UniProt   NCBI
RAB22A	Ras-related protein Rab-22A (Rab-22)	5	UniProt   NCBI
RAB6C	Ras-related protein Rab-6C (Rab6-like protein WTH3)	5	UniProt   NCBI
RABIF	Guanine nucleotide exchange factor MSS4 (Rab-interacting factor)	5	UniProt   NCBI
RAB8A	Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)	5	UniProt   NCBI
RAB10	Ras-related protein Rab-10 (EC 3.6.5.2)	5	UniProt   NCBI
RAB31	Ras-related protein Rab-31 (Ras-related protein Rab-22B)	5	UniProt   NCBI
RAB4B	Ras-related protein Rab-4B (EC 3.6.5.2)	5	UniProt   NCBI
RAB4A	Ras-related protein Rab-4A (EC 3.6.5.2)	5	UniProt   NCBI
GDI1	Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4)	5	UniProt   NCBI
RAB8B	Ras-related protein Rab-8B	5	UniProt   NCBI
RAB13	Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)	5	UniProt   NCBI
A6NDJ8		None	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8873719	4.67729634814e-17	0.692307692308	RAB10 RAB13 RAB8A RAB31 RAB8B RAB22A RAB6A RAB34 RAB4B	RAB geranylgeranylation
REAC:R-HSA-8876198	5.6254259005e-11	0.538461538462	RAB10 RAB13 RAB8A RAB6A RAB8B RAB31 GDI1	RAB GEFs exchange GTP for GDP on RABs
REAC:R-HSA-9007101	4.46715765781e-10	0.538461538462	RAB10 RAB13 RAB8A RAB6A RAB8B RAB31 GDI1	Rab regulation of trafficking
GO:0048193	7.35777454314e-09	0.692307692308	RAB10 RAB13 RAB8A RABIF RAB6A RAB8B RAB31 RAB6C RAB34	Golgi vesicle transport
GO:0016192	1.8511201906e-08	0.923076923077	RAB10 RAB13 RAB8A RABIF RAB6A RAB8B RAB31 GDI1 RAB22A RAB6C RAB34 RAB4B	vesicle-mediated transport
GO:0032561	5.5107181868e-08	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	guanyl ribonucleotide binding
GO:0019001	5.74220920314e-08	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	guanyl nucleotide binding
GO:0003924	3.01717781146e-07	0.615384615385	RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13 RAB4B	GTPase activity
REAC:R-HSA-597592	1.08001743465e-06	0.769230769231	RAB10 RAB13 RAB8A RAB6A USP25 RAB8B RAB22A RAB31 RAB34 RAB4B	Post-translational protein modification
GO:0005525	2.52734971515e-06	0.538461538462	RAB10 RAB8A RAB6A RAB22A RAB31 RAB13 RAB4B	GTP binding
GO:0017111	8.09306613412e-06	0.615384615385	RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13 RAB4B	ribonucleoside triphosphate phosphatase activity
GO:0016818	2.04016528965e-05	0.615384615385	RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13 RAB4B	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016462	2.04016528965e-05	0.615384615385	RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13 RAB4B	pyrophosphatase activity
GO:0016817	2.04016528965e-05	0.615384615385	RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13 RAB4B	hydrolase activity, acting on acid anhydrides
REAC:R-HSA-392499	2.5956925309e-05	0.769230769231	RAB10 RAB13 RAB8A RAB6A USP25 RAB8B RAB22A RAB31 RAB34 RAB4B	Metabolism of proteins
GO:0045184	2.5989491011e-05	0.769230769231	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 GDI1 RAB22A RAB6A RAB34	establishment of protein localization
GO:0098876	3.43109852436e-05	0.461538461538	RAB10 RAB8A RAB31 RAB8B RAB13 RAB34	vesicle-mediated transport to the plasma membrane
GO:0072657	4.04880907986e-05	0.615384615385	RAB10 RAB13 RAB8A RAB31 RAB6A RAB8B RAB34 GDI1	protein localization to membrane
REAC:R-HSA-199991	5.24099510606e-05	0.538461538462	RAB10 RAB13 RAB8A RAB6A RAB8B RAB31 GDI1	Membrane Trafficking
GO:0032555	6.44164153096e-05	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	purine ribonucleotide binding
GO:0032553	7.35342550565e-05	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	ribonucleotide binding
REAC:R-HSA-5653656	7.59113765594e-05	0.538461538462	RAB10 RAB13 RAB8A RAB6A RAB8B RAB31 GDI1	Vesicle-mediated transport
GO:0019003	7.9324144895e-05	0.384615384615	RAB22A RAB8B RAB8A RAB31 RAB10	GDP binding
GO:0015031	8.42951485318e-05	0.692307692308	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 RAB22A RAB6A RAB34	protein transport
GO:0048210	0.000109904886398	0.230769230769	RAB13 RAB8A RAB8B	Golgi vesicle fusion to target membrane
GO:0051668	0.000157962287886	0.615384615385	RAB10 RAB13 RAB8A RAB31 RAB6A RAB8B RAB34 GDI1	localization within membrane
GO:0017076	0.000170078636175	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	purine nucleotide binding
GO:0045335	0.000366472005037	0.384615384615	RAB34 RAB8B RAB8A RAB31 RAB22A	phagocytic vesicle
GO:0071702	0.000379481230133	0.769230769231	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 RAB22A RAB6A RAB34 RAB4B	organic substance transport
GO:0000166	0.00050818133146	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	nucleotide binding
GO:1901265	0.000514694602699	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	nucleoside phosphate binding
GO:0090150	0.000628299366507	0.461538461538	RAB10 RAB8A RAB31 RAB8B RAB34 GDI1	establishment of protein localization to membrane
GO:1901363	0.000873005141531	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	heterocyclic compound binding
GO:0032593	0.000960187650128	0.230769230769	RAB10 RAB4B RAB13	insulin-responsive compartment
GO:0035639	0.00108330329278	0.538461538462	RAB10 RAB8A RAB6A RAB22A RAB31 RAB13 RAB4B	purine ribonucleoside triphosphate binding
GO:0097367	0.00110289598751	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	carbohydrate derivative binding
GO:0006810	0.00112624997623	0.923076923077	RAB10 RAB13 RAB8A RABIF RAB6A RAB8B RAB31 GDI1 RAB22A RAB6C RAB34 RAB4B	transport
GO:0072659	0.0011429088336	0.461538461538	RAB10 RAB8A RAB31 RAB8B RAB13 RAB34	protein localization to plasma membrane
REAC:R-HSA-8854214	0.00134771406413	0.230769230769	RAB6A RAB8A RAB8B	TBC/RABGAPs
GO:0016197	0.00158437433923	0.461538461538	RAB10 RAB8A RAB6A RAB8B RAB6C RAB13	endosomal transport
GO:0071705	0.00167832635474	0.692307692308	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 RAB22A RAB6A RAB34	nitrogen compound transport
GO:0098791	0.00206035323889	0.461538461538	RAB10 RAB8A RAB31 RAB6A RAB13 RAB34	Golgi apparatus subcompartment
GO:0030139	0.00210892402853	0.461538461538	RAB8A RAB31 RAB8B RAB22A RAB13 RAB34	endocytic vesicle
KEGG:04144	0.00222364516397	0.307692307692	RAB22A RAB8A RAB31 RAB10	Endocytosis
GO:1990778	0.002476152847	0.461538461538	RAB10 RAB8A RAB31 RAB8B RAB13 RAB34	protein localization to cell periphery
GO:0070382	0.00267774204771	0.384615384615	RAB6A RAB8B RAB13 RAB8A RAB10	exocytic vesicle
GO:0061025	0.00301361341841	0.384615384615	RAB34 RAB8B RAB13 RAB8A RABIF	membrane fusion
GO:0051234	0.00329810686009	0.923076923077	RAB10 RAB13 RAB8A RABIF RAB6A RAB8B RAB31 GDI1 RAB22A RAB6C RAB34 RAB4B	establishment of localization
GO:0008104	0.00344028520283	0.769230769231	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 GDI1 RAB22A RAB6A RAB34	protein localization
GO:0070727	0.00352180576926	0.769230769231	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 GDI1 RAB22A RAB6A RAB34	cellular macromolecule localization
GO:0055037	0.00392835787862	0.384615384615	RAB10 RAB8B RAB13 RAB8A RAB4B	recycling endosome
GO:0043168	0.00427679270915	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB22A RAB31 RAB13 RAB4B	anion binding
REAC:R-HSA-1445148	0.00760824791989	0.230769230769	RAB10 RAB8A RAB13	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:0031489	0.00995012273459	0.230769230769	RAB6A RAB8A RAB10	myosin V binding
KEGG:04530	0.012845956021	0.230769230769	RAB13 RAB8A RAB8B	Tight junction
GO:0033036	0.0167088371609	0.769230769231	RAB10 RAB13 RAB8A RAB6C RAB8B RAB31 GDI1 RAB22A RAB6A RAB34	macromolecule localization
GO:0051179	0.0199727124555	0.923076923077	RAB10 RAB13 RAB8A RABIF RAB6A RAB8B RAB31 GDI1 RAB22A RAB6C RAB34 RAB4B	localization
GO:0019882	0.023294636818	0.307692307692	RAB34 RAB10 RAB8B RAB6A	antigen processing and presentation
GO:0043167	0.0302601710661	0.692307692308	RAB10 RAB8A RABIF RAB8B RAB31 RAB22A RAB6A RAB13 RAB4B	ion binding
GO:0016787	0.03508465807	0.692307692308	RAB8A RAB6A USP25 RAB31 RAB8B RAB22A RAB6C RAB13 RAB4B	hydrolase activity
GO:0046907	0.0401735849976	0.615384615385	RAB10 RAB8A RAB6A RAB8B RAB31 RAB22A RAB6C RAB13	intracellular transport
GO:0005802	0.0402505661889	0.384615384615	RAB6A RAB13 RAB8A RAB31 RAB10	trans-Golgi network
GO:0005768	0.0407741105849	0.538461538462	RAB10 RAB8A RAB31 RAB8B RAB22A RAB13 RAB4B	endosome
GO:0006906	0.0460739534529	0.307692307692	RAB34 RAB13 RAB8A RAB8B	vesicle fusion
GO:0006887	0.0481399816986	0.384615384615	RAB10 RAB8B RAB13 RAB8A RAB31	exocytosis



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Interface Overlap?
RAB8A	RAB8B	1.0	0.26	structurally_consistent (dimer)
GDI1	RAB12	0.999	0.064	structurally_consistent (dimer)
RAB8B	RABIF	0.999	0.062	structurally_consistent (dimer)
GDI1	RAB8B	0.999	0.1	structurally_consistent (dimer)
RAB4A	GDI1	0.999	0.156	structurally_consistent (dimer)
RAB22A	GDI1	0.999	0.058	structurally_consistent (dimer)
GDI1	RAB8A	0.999	0.132	structurally_consistent (dimer)
RAB4B	RAB4A	0.998	0.162	mutually_exclusive (P31150)
RAB4B	GDI1	0.998	0.104	mutually_exclusive (P24386)         structurally_consistent (dimer)
GDI1	RAB6A	0.998	0.26	structurally_consistent (dimer)
RAB8A	RABIF	0.998	0.282	structurally_consistent (dimer)
GDI1	RAB13	0.997	0.05	structurally_consistent (dimer)
RABIF	RAB13	0.996	0.13	structurally_consistent (dimer)
GDI1	RAB10	0.996	0.132	structurally_consistent (dimer)
RAB8B	RAB13	0.996	0.092
GDI1	RAB34	0.996	0.036
RAB10	RABIF	0.995	0.196	mutually_exclusive (P51153)         structurally_consistent (dimer)
GDI1	USP25	0.995	0.106
RAB4A	RAB31	0.992	0.024	mutually_exclusive (P31150)
RAB22A	RAB31	0.992	0.086	structurally_consistent (dimer)
RAB34	RAB31	0.99	0.028
RAB34	RAB10	0.989	0.082
RAB34	RAB6A	0.988	0.036
GDI1	RAB31	0.988	0.028	structurally_consistent (dimer)
RAB10	RAB13	0.988	0.116	mutually_exclusive (P31150)         structurally_consistent (dimer)
RAB31	RAB6A	0.987	0.166	structurally_consistent (dimer)
RAB12	RAB31	0.985	0.132	mutually_exclusive (P31150)
RAB8A	RAB31	0.981	0.224	mutually_exclusive (P31150)
RAB4A	RAB34	0.98	0.036
GDI1	RABIF	0.978	0.084	mutually_exclusive (P51153)
RAB10	RAB6A	0.974	0.5
RAB31	RAB13	0.974	0.108	mutually_exclusive (P31150)
RAB34	RAB13	0.967	0.064
RAB6C	GDI1	0.967	0.032	structurally_consistent (dimer)
RAB34	RAB12	0.964	0.062
RAB10	RAB31	0.963	0.274	mutually_exclusive (P31150)
RAB34	RAB8A	0.963	0.17
GDI1	A6NDJ8	0.953
RAB4A	RAB8A	0.944	0.232	mutually_exclusive (P31150)         structurally_consistent (dimer)
RAB4A	RAB12	0.944	0.13	mutually_exclusive (P31150)
RAB8A	RAB10	0.919	0.784	mutually_exclusive (P31150)
RAB22A	RAB6A	0.917	0.27	structurally_consistent (dimer)
RAB4B	RAB22A	0.916	0.186
RAB4B	RAB12	0.916	0.022	mutually_exclusive (P31150)
RAB22A	RAB12	0.911	0.124
RAB4A	RAB6A	0.905	0.148
RAB6C	A6NDJ8	0.904
RAB6C	RAB12	0.902	0.026
RAB22A	RAB6C	0.902	0.1	mutually_exclusive (P31150)
RAB4B	A6NDJ8	0.897
RAB22A	A6NDJ8	0.896
A6NDJ8	RAB12	0.896
A6NDJ8	RAB6A	0.895
RAB8A	RAB6A	0.891	0.274	structurally_consistent (dimer)
RAB12	RAB8A	0.89	0.288	mutually_exclusive (P31150)
RAB6A	RAB13	0.889	0.156
RAB4A	RAB22A	0.884	0.162
RAB12	RAB8B	0.877	0.046
RAB22A	RAB8B	0.877	0.116
RAB22A	RAB8A	0.877	0.162
A6NDJ8	RAB8B	0.868
A6NDJ8	RAB8A	0.861
RAB6C	RAB6A	0.849	0.142	mutually_exclusive (P31150)
RAB12	RAB6A	0.829	0.14
RAB4A	A6NDJ8	0.825
RAB4B	RAB6A	0.82	0.22
RAB4B	RAB8B	0.805	0.09
RAB12	RAB13	0.796	0.088	mutually_exclusive (P31150)
RAB8A	RAB13	0.787	0.236	mutually_exclusive (P31150)         structurally_consistent (dimer)
RAB4A	RAB8B	0.754	0.072
RAB4B	RAB6C	0.717	0.098	mutually_exclusive (P31150)
RAB4A	RAB6C	0.696	0.04	mutually_exclusive (P31150)
RAB12	RAB10	0.673	0.438	mutually_exclusive (P31150)
RAB4A	RAB13	0.663	0.106	mutually_exclusive (P31150)
RAB4B	RAB8A	0.633	0.129	mutually_exclusive (P31150)
A6NDJ8	RAB10	0.608
RAB4A	RAB10	0.59	0.266	mutually_exclusive (P31150)
RAB22A	RAB10	0.589	0.138
RAB4B	RAB31	0.572	0.042	mutually_exclusive (P31150)
A6NDJ8	RAB31	0.502
USP25	RAB6A	0.494	0.112
RAB22A	RAB13	0.47	0.072
RAB6C	RAB8B	0.468	0.052	mutually_exclusive (P31150)
A6NDJ8	RAB13	0.451
RAB8B	RAB6A	0.446	0.142
RAB6C	RAB8A	0.437	0.06	mutually_exclusive (P31150)
RAB10	RAB8B	0.432	0.18
RAB4B	RAB13	0.37	0.028	mutually_exclusive (P31150)
RAB22A	USP25	0.333	0.08
RAB12	USP25	0.333	0.09
RAB31	USP25	0.333	0.072
RAB4B	USP25	0.333	0.108
RAB22A	RAB34	0.333	0.024
RAB4B	RAB34	0.333	0.01
RAB4B	RAB10	0.269	0.22	mutually_exclusive (P31150)
RAB10	USP25	0.22	0.09
RAB6C	RAB31	0.214	0.05	mutually_exclusive (P31150)
RAB8A	USP25	0.213	0.288
RAB34	A6NDJ8	0.172
A6NDJ8	USP25	0.164
RAB8B	USP25	0.164	0.06
RAB34	USP25	0.164	0.086
RAB6C	RAB10	0.154	0.044
RAB31	RAB8B	0.153	0.042
RAB4A	USP25	0.143	0.098
RAB34	RAB8B	0.143	0.054
RAB6C	RAB13	0.096	0.058	mutually_exclusive (P31150)
USP25	RAB13	0.058	0.048
RAB6C	RAB34	0.046	0.038
RAB6C	USP25	0.043	0.09
RAB4A	RABIF	0.016	0.12
RAB6A	RABIF	0.009	0.184





Related Complexes

Genename	Complexes
RAB12	huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB34	huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1 huMAP3_15132.1
USP25	huMAP3_03808.1 huMAP3_06607.1 huMAP3_07744.1 huMAP3_10939.1 huMAP3_11515.1 huMAP3_12888.1 huMAP3_13664.1 huMAP3_14151.1 huMAP3_14727.1
RAB6A	huMAP3_06565.1 huMAP3_06607.1 huMAP3_06933.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08503.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB22A	huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB6C	huMAP3_01895.1 huMAP3_04982.1 huMAP3_06090.1 huMAP3_06607.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11456.1 huMAP3_11860.1 huMAP3_13225.1
RABIF	huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB8A	huMAP3_01895.1 huMAP3_04118.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB10	huMAP3_01895.1 huMAP3_06565.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB31	huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB4B	huMAP3_00611.1 huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_10676.1 huMAP3_11094.1 huMAP3_11860.1
RAB4A	huMAP3_00611.1 huMAP3_06607.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_10676.1 huMAP3_11094.1 huMAP3_11860.1
GDI1	huMAP3_01895.1 huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1
RAB8B	huMAP3_02531.1 huMAP3_06607.1 huMAP3_11094.1 huMAP3_11860.1
RAB13	huMAP3_06607.1 huMAP3_06994.1 huMAP3_07302.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11605.1
A6NDJ8	huMAP3_01895.1 huMAP3_06607.1 huMAP3_08941.1 huMAP3_09217.1 huMAP3_11094.1 huMAP3_11860.1