hu.MAP 3.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Uniprot Annotation Score	Links
SNTA1	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)	5	UniProt NCBI
SNTG1	Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4)	5	UniProt NCBI
SNTB1	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)	5	UniProt NCBI
DTNA	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	5	UniProt NCBI
DMD	Dystrophin	5	UniProt NCBI
UTRN	Utrophin (Dystrophin-related protein 1) (DRP-1)	5	UniProt NCBI
CTNNAL1	Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1)	5	UniProt NCBI
TAGAP	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)	4	UniProt NCBI
SNTG2	Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5)	5	UniProt NCBI
SNTB2	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)	5	UniProt NCBI
DTNB	Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016010	2.91368265705e-09	0.5	SNTA1 SNTG2 SNTB2 SNTB1 SNTG1	dystrophin-associated glycoprotein complex
GO:0090665	1.39932395176e-08	0.5	SNTA1 SNTG2 SNTB2 SNTB1 SNTG1	glycoprotein complex
KEGG:05416	1.73110640111e-06	0.4	SNTA1 SNTB2 SNTB1 DTNA	Viral myocarditis
KEGG:05412	4.4373016651e-06	0.4	SNTA1 SNTB2 SNTB1 DTNA	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05410	6.9720815219e-06	0.4	SNTA1 SNTB2 SNTB1 DTNA	Hypertrophic cardiomyopathy
KEGG:05414	6.9720815219e-06	0.4	SNTA1 SNTB2 SNTB1 DTNA	Dilated cardiomyopathy
CORUM:7341	3.07577115383e-05	0.2	CTNNAL1 DTNA	CTNNAL1-DNTA complex
GO:0016013	4.61210427592e-05	0.3	SNTA1 SNTG2 SNTG1	syntrophin complex
WP:WP5406	7.37177804475e-05	0.3	SNTA1 SNTB1 DTNA	13q12 12 copy number variation
WP:WP5343	0.00227361396611	0.2	SNTB1 DTNA	Abnormal calcium handling and its effects on muscle contraction in DMD

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
DMD	SNTB1	1.0	0.044
DMD	DTNA	1.0	0.098
CTNNAL1	DMD	1.0	0.102
DMD	DTNB	1.0	0.136
DMD	SNTA1	1.0	0.1
DMD	SNTB2	1.0	0.078
SNTG2	SNTA1	1.0
SNTG2	SNTB1	0.999
SNTG2	DTNB	0.999
SNTB2	SNTB1	0.999	0.052
SNTG2	SNTB2	0.999
SNTB2	DTNA	0.999	0.044
SNTB2	SNTA1	0.999	0.068
SNTB2	DTNB	0.999	0.066
CTNNAL1	SNTG2	0.998
SNTG1	SNTA1	0.998
CTNNAL1	SNTB2	0.998	0.066
UTRN	SNTG2	0.997
SNTG1	SNTG2	0.997
SNTG1	SNTB1	0.997
UTRN	SNTB2	0.996	0.132
SNTG2	DTNA	0.996
SNTG1	DTNB	0.995
DTNB	SNTB1	0.995	0.108
DMD	SNTG2	0.995
SNTA1	DTNB	0.995	0.09
UTRN	TAGAP	0.995
SNTG1	DTNA	0.994
SNTG1	UTRN	0.993
UTRN	DTNB	0.991	0.074
SNTG1	SNTB2	0.989
DTNA	DTNB	0.984	0.06	mutually_exclusive (Q9UBT7)
TAGAP	SNTB2	0.982
SNTA1	DTNA	0.982	0.056
SNTA1	SNTB1	0.98	0.08
UTRN	SNTA1	0.974	0.1
UTRN	DMD	0.964	0.096
UTRN	SNTB1	0.96	0.036
DTNA	SNTB1	0.938	0.048
SNTG1	DMD	0.913
CTNNAL1	SNTA1	0.902	0.048
TAGAP	DTNA	0.886
TAGAP	DTNB	0.885
CTNNAL1	SNTB1	0.875	0.026
CTNNAL1	DTNB	0.807	0.096	structurally_consistent (dimer)
SNTG1	CTNNAL1	0.803
UTRN	DTNA	0.762	0.068
CTNNAL1	DTNA	0.762	0.088	structurally_consistent (dimer)
TAGAP	SNTA1	0.727
CTNNAL1	UTRN	0.714	0.09
TAGAP	SNTB1	0.706
CTNNAL1	TAGAP	0.159

Genename	Complexes
SNTA1	huMAP3_05100.1 huMAP3_06618.1 huMAP3_10517.1
SNTG1	huMAP3_01489.1 huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1
SNTB1	huMAP3_05100.1 huMAP3_06618.1 huMAP3_10517.1
DTNA	huMAP3_05100.1 huMAP3_06618.1 huMAP3_10517.1
DMD	huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1
UTRN	huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1
CTNNAL1	huMAP3_02699.1 huMAP3_06618.1 huMAP3_07429.1 huMAP3_10517.1
TAGAP	huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1 huMAP3_12662.1 huMAP3_12667.1
SNTG2	huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1
SNTB2	huMAP3_02993.1 huMAP3_06618.1 huMAP3_10517.1 huMAP3_14575.1
DTNB	huMAP3_05100.1 huMAP3_06618.1 huMAP3_10517.1