hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06620.1

Complex Portal: CPX-11202

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
MPP3	MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)	5	UniProt NCBI
DLG4	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	5	UniProt NCBI
KIF26B	Kinesin-like protein KIF26B	4	UniProt NCBI
CASK	Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)	5	UniProt NCBI
APBA1	Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)	5	UniProt NCBI
PXDC1	PX domain-containing protein 1	2	UniProt NCBI
DLG1	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)	5	UniProt NCBI
PATJ	InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions)	5	UniProt NCBI
MPP7	MAGUK p55 subfamily member 7	5	UniProt NCBI
CRB3	Protein crumbs homolog 3	5	UniProt NCBI
LIN7B	Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)	5	UniProt NCBI
LIN7C	Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9609736	5.06907291114e-11	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Assembly and cell surface presentation of NMDA receptors
REAC:R-HSA-6794362	2.38046878272e-09	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Protein-protein interactions at synapses
REAC:R-HSA-442755	5.43646956142e-09	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Activation of NMDA receptors and postsynaptic events
GO:0005911	6.75028030596e-09	0.75	MPP3 LIN7C PATJ DLG4 DLG1 CRB3 LIN7B CASK MPP7	cell-cell junction
GO:0045197	9.32709415649e-09	0.5	LIN7C DLG4 PATJ DLG1 CRB3 LIN7B	establishment or maintenance of epithelial cell apical/basal polarity
GO:0061245	1.51751984283e-08	0.5	LIN7C DLG4 PATJ DLG1 CRB3 LIN7B	establishment or maintenance of bipolar cell polarity
GO:0035088	1.51751984283e-08	0.5	LIN7C DLG4 PATJ DLG1 CRB3 LIN7B	establishment or maintenance of apical/basal cell polarity
CORUM:617	2.5725558439e-08	0.25	CASK LIN7C APBA1	CASK-LIN7C-APBA1 complex
CORUM:6263	2.5725558439e-08	0.25	DLG1 MPP7 LIN7C	MPP7-DLG1-LIN7C complex
REAC:R-HSA-6794361	5.22641201794e-08	0.416666666667	CASK LIN7C LIN7B DLG4 APBA1	Neurexins and neuroligins
GO:0097025	6.50952358374e-08	0.333333333333	DLG1 LIN7C MPP7 LIN7B	MPP7-DLG1-LIN7 complex
CORUM:3207	1.02854698163e-07	0.25	DLG1 CASK APBA1	LIN2-LIN7-SAP97-MINT1 complex
REAC:R-HSA-112314	3.45435349892e-07	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-212676	4.20513695266e-07	0.333333333333	CASK LIN7C LIN7B APBA1	Dopamine Neurotransmitter Release Cycle
GO:0007163	5.22208397589e-07	0.583333333333	LIN7C DLG4 PATJ DLG1 CRB3 LIN7B MPP7	establishment or maintenance of cell polarity
REAC:R-HSA-112315	1.56238773554e-06	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Transmission across Chemical Synapses
GO:0070161	3.78202582829e-06	0.75	MPP3 LIN7C PATJ DLG4 DLG1 CRB3 LIN7B CASK MPP7	anchoring junction
REAC:R-HSA-112310	5.14781368193e-06	0.333333333333	CASK LIN7C LIN7B APBA1	Neurotransmitter release cycle
REAC:R-HSA-112316	1.54804454303e-05	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	Neuronal System
GO:0005912	2.13971657727e-05	0.5	MPP3 LIN7C DLG4 DLG1 LIN7B MPP7	adherens junction
GO:0030054	2.63165206288e-05	0.833333333333	MPP3 LIN7C PATJ DLG4 DLG1 LIN7B CRB3 APBA1 CASK MPP7	cell junction
CORUM:3209	3.75927585468e-05	0.166666666667	CASK DLG1	LIN2-SAP97 complex
GO:0097016	8.45465618902e-05	0.25	DLG1 LIN7C LIN7B	L27 domain binding
CORUM:6260	0.000112726824524	0.166666666667	DLG1 MPP7	MPP7-DLG1-LIN7A complex
CORUM:1448	0.000112726824524	0.166666666667	CASK DLG1	LIN2-LIN7-SAP97 complex
GO:0098590	0.000144388107874	0.666666666667	MPP3 LIN7C PATJ DLG4 DLG1 CRB3 LIN7B CASK	plasma membrane region
CORUM:848	0.00104971930231	0.166666666667	PATJ MPP7	RICH1/AMOT polarity complex, Flag-Amot precipitated
REAC:R-HSA-9705677	0.00167711816531	0.166666666667	PATJ CRB3	SARS-CoV-2 targets PDZ proteins in cell-cell junction
REAC:R-HSA-451306	0.00167711816531	0.166666666667	DLG1 DLG4	Ionotropic activity of kainate receptors
REAC:R-HSA-451308	0.00167711816531	0.166666666667	DLG1 DLG4	Activation of Ca-permeable Kainate Receptor
GO:0016323	0.00243563006943	0.416666666667	CASK LIN7C LIN7B DLG4 DLG1	basolateral plasma membrane
REAC:R-HSA-447038	0.00351873541523	0.166666666667	DLG1 DLG4	NrCAM interactions
GO:0009925	0.00469089276786	0.416666666667	CASK LIN7C LIN7B DLG4 DLG1	basal plasma membrane
WP:WP5417	0.00486593783382	0.25	CASK DLG4 DLG1	Cell lineage map for neuronal differentiation
GO:0045178	0.0058503701083	0.416666666667	CASK LIN7C LIN7B DLG4 DLG1	basal part of cell
GO:0007268	0.00777756964421	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	chemical synaptic transmission
GO:0098916	0.00777756964421	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	anterograde trans-synaptic signaling
GO:0099537	0.00831363362559	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	trans-synaptic signaling
KEGG:04530	0.00904045358884	0.25	DLG1 PATJ CRB3	Tight junction
KEGG:04390	0.0104532139401	0.25	DLG1 DLG4 PATJ	Hippo signaling pathway
GO:0099536	0.0116542230854	0.5	LIN7C APBA1 DLG4 DLG1 LIN7B CASK	synaptic signaling
GO:0019904	0.0142279910379	0.5	LIN7C DLG4 DLG1 CRB3 LIN7B MPP7	protein domain specific binding
REAC:R-HSA-442982	0.0151992282354	0.166666666667	DLG1 DLG4	Ras activation upon Ca2+ influx through NMDA receptor
REAC:R-HSA-420029	0.0175295706997	0.166666666667	PATJ CRB3	Tight junction interactions
REAC:R-HSA-1500931	0.0194059940126	0.25	CASK PATJ CRB3	Cell-Cell communication
GO:0043296	0.0199241034825	0.333333333333	DLG1 CRB3 PATJ MPP7	apical junction complex
REAC:R-HSA-438066	0.0226842574326	0.166666666667	DLG1 DLG4	Unblocking of NMDA receptors, glutamate binding and activation
REAC:R-HSA-9617324	0.0226842574326	0.166666666667	DLG1 DLG4	Negative regulation of NMDA receptor-mediated neuronal transmission
REAC:R-HSA-8849932	0.0255081481249	0.166666666667	DLG1 DLG4	Synaptic adhesion-like molecules
REAC:R-HSA-9620244	0.0255081481249	0.166666666667	DLG1 DLG4	Long-term potentiation
REAC:R-HSA-451326	0.0384420778088	0.166666666667	DLG1 DLG4	Activation of kainate receptors upon glutamate binding
REAC:R-HSA-442742	0.0384420778088	0.166666666667	DLG1 DLG4	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
REAC:R-HSA-399719	0.0498564867004	0.166666666667	DLG1 DLG4	Trafficking of AMPA receptors
REAC:R-HSA-399721	0.0498564867004	0.166666666667	DLG1 DLG4	Glutamate binding, activation of AMPA receptors and synaptic plasticity
CORUM:1909	0.0499436884912	0.0833333333333	DLG4	APC-DLG4 complex
CORUM:4869	0.0499436884912	0.0833333333333	DLG1	beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)
CORUM:6321	0.0499436884912	0.0833333333333	DLG4	DLG4-DLGAP1-SHANK3 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
DLG1	LIN7C	1.0
MPP7	LIN7C	0.999	0.078	structurally_consistent (dimer)
APBA1	CASK	0.999
CASK	LIN7C	0.999
APBA1	DLG1	0.999
APBA1	LIN7C	0.999	0.098
MPP3	LIN7C	0.998
PXDC1	LIN7C	0.998	0.17
DLG1	LIN7B	0.997
CASK	LIN7B	0.997
APBA1	LIN7B	0.997
CASK	DLG1	0.997
LIN7B	LIN7C	0.996
DLG1	MPP7	0.996
CASK	MPP7	0.995
MPP7	LIN7B	0.995
PXDC1	LIN7B	0.994
KIF26B	LIN7C	0.994	0.124
APBA1	PXDC1	0.993	0.13
MPP3	LIN7B	0.991
CASK	PXDC1	0.991
KIF26B	MPP7	0.984	0.102
DLG4	LIN7C	0.982	0.178
APBA1	DLG4	0.981	0.106
CRB3	LIN7C	0.978		structurally_consistent (Q8N3R9)
MPP3	PXDC1	0.967
APBA1	MPP3	0.967
KIF26B	DLG1	0.967
MPP3	CASK	0.96
MPP3	DLG1	0.958
MPP3	MPP7	0.958
PXDC1	DLG1	0.95
KIF26B	LIN7B	0.937
DLG4	CRB3	0.902
CRB3	MPP3	0.902
DLG4	MPP3	0.902
APBA1	MPP7	0.898	0.088
PXDC1	MPP7	0.888	0.082
KIF26B	CASK	0.88
APBA1	CRB3	0.717
CRB3	PXDC1	0.717
KIF26B	PXDC1	0.691	0.064
DLG4	LIN7B	0.64
DLG4	CASK	0.633
DLG4	DLG1	0.633
DLG4	PXDC1	0.616	0.096
MPP3	KIF26B	0.583
APBA1	KIF26B	0.566	0.068
CRB3	CASK	0.459
DLG4	MPP7	0.45	0.096
CRB3	MPP7	0.45
CRB3	DLG1	0.437
CRB3	LIN7B	0.352		structurally_consistent (Q8N3R9)
CRB3	KIF26B	0.214
DLG4	KIF26B	0.214	0.186

Related Complexes

Genename	Complexes
MPP3	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
DLG4	huMAP3_00243.1 huMAP3_05036.1 huMAP3_05627.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
KIF26B	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
CASK	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
APBA1	huMAP3_00243.1 huMAP3_05627.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
PXDC1	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
DLG1	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
PATJ	huMAP3_05036.1 huMAP3_06620.1 huMAP3_07872.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
MPP7	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
CRB3	huMAP3_03320.1 huMAP3_04256.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_10760.1 huMAP3_11195.1 huMAP3_11270.1 huMAP3_14575.1
LIN7B	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1
LIN7C	huMAP3_05036.1 huMAP3_06620.1 huMAP3_08198.1 huMAP3_08481.1 huMAP3_09519.1 huMAP3_11195.1 huMAP3_14575.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06620.1

Complex Portal: CPX-11202