hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06628.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
POLDIP3	Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)	5	UniProt NCBI
NCBP3	Nuclear cap-binding protein subunit 3 (Protein ELG)	5	UniProt NCBI
THOC6	THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)	5	UniProt NCBI
RSPO1	R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)	5	UniProt NCBI
DDX39A	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	5	UniProt NCBI
ALYREF	THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)	5	UniProt NCBI
THOC3	THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)	5	UniProt NCBI
CHTOP	Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)	5	UniProt NCBI
ALKBH5	RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)	5	UniProt NCBI
FXR1	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	5	UniProt NCBI
DDX39B	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	5	UniProt NCBI
FYTTD1	UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3)	5	UniProt NCBI
THOC7	THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006406	5.66025089687e-18	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	mRNA export from nucleus
GO:0051028	1.43748773851e-17	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	mRNA transport
GO:0006405	8.37509916506e-17	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	RNA export from nucleus
GO:0050658	9.37854097198e-16	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	RNA transport
GO:0050657	9.37854097198e-16	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nucleic acid transport
GO:0051236	1.25127784373e-15	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	establishment of RNA localization
REAC:R-HSA-72187	3.1422180212e-15	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	mRNA 3'-end processing
REAC:R-HSA-73856	9.975416697e-15	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	RNA Polymerase II Transcription Termination
GO:0006403	1.52483546872e-14	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	RNA localization
GO:0051168	1.76512798205e-14	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nuclear export
REAC:R-HSA-159236	2.42739743192e-14	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	Transport of Mature mRNA derived from an Intron-Containing Transcript
GO:0015931	2.8982488591e-14	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nucleobase-containing compound transport
REAC:R-HSA-72202	6.69347039979e-14	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	Transport of Mature Transcript to Cytoplasm
GO:0006913	4.12617338879e-12	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nucleocytoplasmic transport
GO:0051169	4.12617338879e-12	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nuclear transport
CORUM:770	5.53853439501e-10	0.333333333333	THOC7 DDX39B THOC6 THOC3	TREX complex
REAC:R-HSA-72203	1.73807623491e-09	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	Processing of Capped Intron-Containing Pre-mRNA
GO:0000346	3.28685663218e-09	0.416666666667	THOC7 DDX39B CHTOP THOC6 THOC3	transcription export complex
GO:0016607	5.14036309143e-09	0.75	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A DDX39B	nuclear speck
GO:0044417	4.5526752727e-07	0.333333333333	THOC7 DDX39B THOC6 THOC3	translocation of molecules into host
GO:0046784	4.5526752727e-07	0.333333333333	THOC7 DDX39B THOC6 THOC3	viral mRNA export from host cell nucleus
CORUM:6160	5.13798447177e-07	0.25	THOC7 THOC6 THOC3	hTREX84 complex
REAC:R-HSA-8953854	2.51700385471e-06	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	Metabolism of RNA
GO:0016604	6.73857883808e-06	0.75	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A DDX39B	nuclear body
GO:0071705	1.29464534838e-05	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	nitrogen compound transport
GO:0046907	1.35543949086e-05	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	intracellular transport
KEGG:03013	5.29754774731e-05	0.333333333333	THOC7 DDX39B THOC6 THOC3	Nucleocytoplasmic transport
GO:0071702	9.53164580591e-05	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	organic substance transport
REAC:R-HSA-73857	0.000139213139881	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	RNA Polymerase II Transcription
GO:0051649	0.000158745323704	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	establishment of localization in cell
CORUM:351	0.000209900402146	0.333333333333	THOC7 DDX39B THOC6 THOC3	Spliceosome
REAC:R-HSA-74160	0.000366136880285	0.666666666667	CHTOP THOC3 THOC7 DDX39B FYTTD1 THOC6 DDX39A POLDIP3	Gene expression (Transcription)
CORUM:774	0.000375413311943	0.166666666667	THOC6 THOC7	THO complex
GO:0000347	0.00042234232358	0.25	THOC7 THOC6 THOC3	THO complex
GO:0000445	0.00042234232358	0.25	THOC7 THOC6 THOC3	THO complex part of transcription export complex
HPA:0460663	0.00046087489261	0.5	ALKBH5 NCBP3 CHTOP DDX39B FYTTD1 FXR1	skin 1; keratinocytes[High]
GO:0051641	0.00109462381825	0.916666666667	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 FXR1 DDX39A THOC3 DDX39B	cellular localization
HPA:0380513	0.00122659504032	0.583333333333	ALKBH5 CHTOP NCBP3 DDX39B FYTTD1 FXR1 THOC3	placenta; decidual cells[High]
HPA:0060103	0.00134657257461	0.666666666667	ALKBH5 CHTOP NCBP3 POLDIP3 FYTTD1 FXR1 THOC3 DDX39B	bronchus; respiratory epithelial cells[High]
GO:0051179	0.00197652202779	1.0	ALKBH5 NCBP3 RSPO1 THOC6 DDX39B POLDIP3 FYTTD1 THOC7 FXR1 DDX39A THOC3 CHTOP	localization
HPA:0610833	0.00282896538328	0.666666666667	ALKBH5 CHTOP NCBP3 POLDIP3 FYTTD1 FXR1 THOC3 DDX39B	urinary bladder; urothelial cells[High]
GO:0033036	0.00438290225455	0.833333333333	ALKBH5 NCBP3 CHTOP THOC6 THOC7 POLDIP3 FYTTD1 DDX39A THOC3 DDX39B	macromolecule localization
HPA:0460643	0.00476907574426	0.416666666667	ALKBH5 FYTTD1 DDX39B NCBP3 CHTOP	skin 1; Langerhans[High]
HPA:0620222	0.00539323604483	0.833333333333	ALKBH5 NCBP3 CHTOP THOC3 THOC7 POLDIP3 FYTTD1 FXR1 DDX39A DDX39B	vagina; squamous epithelial cells[>=Medium]
GO:0006810	0.00551263924131	0.916666666667	ALKBH5 NCBP3 RSPO1 THOC6 DDX39B POLDIP3 THOC7 FYTTD1 DDX39A THOC3 CHTOP	transport
HPA:0470683	0.00687117635249	0.5	CHTOP NCBP3 DDX39B FYTTD1 FXR1 POLDIP3	skin 2; epidermal cells[High]
HPA:0460662	0.0087870739766	0.75	ALKBH5 CHTOP NCBP3 THOC7 POLDIP3 FYTTD1 FXR1 THOC3 DDX39B	skin 1; keratinocytes[>=Medium]
HPA:0210053	0.0093996806627	0.583333333333	ALKBH5 CHTOP NCBP3 DDX39B FXR1 THOC7 POLDIP3	fallopian tube; glandular cells[High]
HPA:0620223	0.0115424243942	0.5	CHTOP NCBP3 DDX39B FYTTD1 FXR1 THOC3	vagina; squamous epithelial cells[High]
HPA:0330223	0.013337325813	0.5	CHTOP NCBP3 POLDIP3 FYTTD1 FXR1 THOC3	oral mucosa; squamous epithelial cells[High]
GO:0051234	0.0147354901035	0.916666666667	ALKBH5 NCBP3 RSPO1 THOC6 DDX39B POLDIP3 THOC7 FYTTD1 DDX39A THOC3 CHTOP	establishment of localization
HPA:0340463	0.0206923872087	0.333333333333	ALKBH5 CHTOP POLDIP3 NCBP3	ovary; ovarian stroma cells[High]
HPA:0060102	0.0310587535007	0.833333333333	ALKBH5 NCBP3 CHTOP THOC3 THOC7 POLDIP3 FYTTD1 FXR1 DDX39A DDX39B	bronchus; respiratory epithelial cells[>=Medium]
HPA:0220053	0.0345068762131	0.666666666667	ALKBH5 CHTOP NCBP3 THOC7 POLDIP3 FXR1 THOC3 DDX39B	gallbladder; glandular cells[High]
HPA:0440343	0.0356170930279	0.416666666667	ALKBH5 FYTTD1 DDX39B NCBP3 CHTOP	skeletal muscle; myocytes[High]
HPA:0460641	0.0399548215156	0.75	ALKBH5 CHTOP NCBP3 THOC7 DDX39B FYTTD1 FXR1 THOC3 DDX39A	skin 1; Langerhans[>=Low]
HPA:0460661	0.0422268894731	0.833333333333	ALKBH5 NCBP3 CHTOP THOC3 THOC7 POLDIP3 FYTTD1 FXR1 DDX39A DDX39B	skin 1; keratinocytes[>=Low]
HPA:0470682	0.0488252296425	0.75	ALKBH5 CHTOP NCBP3 THOC7 POLDIP3 FYTTD1 FXR1 THOC3 DDX39B	skin 2; epidermal cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD
THOC3	THOC7	1.0	0.1
THOC6	THOC3	1.0	0.342
THOC6	THOC7	1.0	0.526
CHTOP	FYTTD1	1.0	0.086
THOC6	NCBP3	0.999	0.448
ALYREF	CHTOP	0.999	0.572
THOC7	NCBP3	0.999	0.14
THOC6	DDX39B	0.999	0.408
DDX39B	NCBP3	0.998	0.208
DDX39A	DDX39B	0.998	0.446
CHTOP	DDX39B	0.998	0.684
THOC6	DDX39A	0.997	0.164
POLDIP3	THOC7	0.997	0.3
CHTOP	NCBP3	0.997	0.208
ALYREF	NCBP3	0.997	0.298
FYTTD1	NCBP3	0.996	0.114
DDX39B	THOC7	0.996	0.242
CHTOP	THOC7	0.996	0.252
RSPO1	CHTOP	0.995
THOC7	FYTTD1	0.995	0.106
POLDIP3	ALKBH5	0.994	0.164
POLDIP3	THOC6	0.992	0.304
CHTOP	FXR1	0.991	0.178
POLDIP3	FYTTD1	0.99	0.194
DDX39A	NCBP3	0.99	0.086
CHTOP	DDX39A	0.988	0.13
THOC3	DDX39B	0.986	0.238
THOC6	FYTTD1	0.985	0.248
THOC3	ALYREF	0.984	0.246
THOC3	FYTTD1	0.984	0.048
FXR1	NCBP3	0.983	0.076
ALYREF	DDX39B	0.983	0.816
THOC3	NCBP3	0.98	0.108
ALYREF	THOC7	0.979	0.242
DDX39A	FYTTD1	0.977	0.098
CHTOP	ALKBH5	0.975	0.048
ALKBH5	NCBP3	0.975	0.104
POLDIP3	ALYREF	0.974	0.484
THOC3	DDX39A	0.974	0.128
POLDIP3	NCBP3	0.973	0.184
DDX39A	THOC7	0.973	0.168
THOC6	CHTOP	0.972	0.146
ALYREF	DDX39A	0.972	0.406
THOC3	CHTOP	0.97	0.134
THOC6	FXR1	0.968	0.086
ALYREF	ALKBH5	0.966	0.158
FXR1	FYTTD1	0.962	0.182666666667
ALYREF	FYTTD1	0.962	0.13685
POLDIP3	CHTOP	0.96	0.322
THOC6	ALYREF	0.949	0.284
THOC7	ALKBH5	0.939	0.062
DDX39B	FYTTD1	0.937	0.09
THOC7	FXR1	0.924	0.184
POLDIP3	DDX39B	0.917	0.266
POLDIP3	THOC3	0.914	0.234
POLDIP3	DDX39A	0.866	0.3
DDX39B	ALKBH5	0.672	0.13
THOC6	ALKBH5	0.663	0.152
THOC3	ALKBH5	0.662	0.034
ALKBH5	FYTTD1	0.65	0.066
POLDIP3	FXR1	0.616	0.242
FXR1	ALKBH5	0.611	0.062
DDX39A	ALKBH5	0.357	0.076
ALYREF	FXR1	0.17	0.19
DDX39B	FXR1	0.128	0.208
THOC6	RSPO1	0.038
THOC3	FXR1	0.016	0.138
DDX39A	FXR1	0.013	0.17
RSPO1	FXR1	0.012
THOC3	RSPO1	0.009
RSPO1	DDX39B	0.008
RSPO1	ALYREF	0.004

Related Complexes

Genename	Complexes
POLDIP3	huMAP3_00031.1 huMAP3_02553.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09643.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
NCBP3	huMAP3_02837.1 huMAP3_04872.1 huMAP3_05846.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1
THOC6	huMAP3_00936.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
RSPO1	huMAP3_00936.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1 huMAP3_13357.1
DDX39A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
ALYREF	huMAP3_00936.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09156.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC3	huMAP3_00936.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1 huMAP3_14379.1
CHTOP	huMAP3_00936.1 huMAP3_01567.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_05846.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1 huMAP3_13357.1
ALKBH5	huMAP3_02553.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_05165.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09583.1 huMAP3_09643.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
FXR1	huMAP3_02301.1 huMAP3_04023.1 huMAP3_06164.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08427.1 huMAP3_09184.1 huMAP3_10663.1 huMAP3_10789.1 huMAP3_13728.1
DDX39B	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
FYTTD1	huMAP3_02837.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_09960.1 huMAP3_10299.1 huMAP3_10789.1
THOC7	huMAP3_02019.1 huMAP3_02553.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06628.1