hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06647.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) | 5 | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | 5 | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | 5 | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | 4 | UniProt NCBI |
| PARVG | Gamma-parvin | 5 | UniProt NCBI |
| PXN | Paxillin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 1.70056796601e-12 | 0.833333333333 | PXN ILK LIMS1 RSU1 PARVB | Cell-extracellular matrix interactions |
| REAC:R-HSA-446388 | 1.01530006227e-10 | 0.666666666667 | PXN LIMS1 RSU1 PARVB | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| REAC:R-HSA-446728 | 2.76846766863e-09 | 0.833333333333 | PXN ILK LIMS1 RSU1 PARVB | Cell junction organization |
| REAC:R-HSA-1500931 | 1.72907958795e-08 | 0.833333333333 | PXN ILK LIMS1 RSU1 PARVB | Cell-Cell communication |
| GO:0031589 | 7.30915747318e-07 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | cell-substrate adhesion |
| GO:0034446 | 1.13580597682e-06 | 0.833333333333 | PXN ILK PARVG LIMS1 PARVB | substrate adhesion-dependent cell spreading |
| GO:0005925 | 9.68599177182e-06 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | focal adhesion |
| GO:0030055 | 1.09025545698e-05 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | cell-substrate junction |
| KEGG:04510 | 1.44548424613e-05 | 0.666666666667 | PXN ILK PARVB PARVG | Focal adhesion |
| WP:WP306 | 2.00335406279e-05 | 0.666666666667 | PXN ILK PARVB PARVG | Focal adhesion |
| CORUM:5498 | 5.12534978153e-05 | 0.333333333333 | ILK PARVB | ILK-PARVB-ARHGEF6 complex |
| CORUM:6919 | 5.12534978153e-05 | 0.333333333333 | ILK LIMS1 | ILK-LIMS1-PARVA complex |
| REAC:R-HSA-446343 | 0.000154862819062 | 0.333333333333 | ILK PXN | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0070161 | 0.000268529178236 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | anchoring junction |
| GO:0007155 | 0.00300414293407 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | cell adhesion |
| GO:0030054 | 0.0120983352343 | 1.0 | LIMS1 PXN ILK PARVG PARVB RSU1 | cell junction |
| WP:WP2572 | 0.0188461436964 | 0.333333333333 | ILK LIMS1 | Primary focal segmental glomerulosclerosis FSGS |
| KEGG:05100 | 0.0204418285401 | 0.333333333333 | ILK PXN | Bacterial invasion of epithelial cells |
| WP:WP185 | 0.0346027913493 | 0.333333333333 | ILK PXN | Integrin mediated cell adhesion |
| CORUM:4025 | 0.0499436884912 | 0.166666666667 | PARVB | ACTN1-PARVB complex |
| CORUM:6510 | 0.0499436884912 | 0.166666666667 | ILK | ILK-SERCA2A-PLN complex |
| CORUM:6927 | 0.0499436884912 | 0.166666666667 | PXN | Robo4-paxillin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ILK | PARVB | 1.0 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction |
| ILK | RSU1 | 1.0 | 0.864 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| ILK | LIMS1 | 1.0 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
| PARVB | RSU1 | 1.0 | 0.062 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| LIMS1 | RSU1 | 1.0 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | LIMS1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIMS1 | PARVB | 0.999 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | RSU1 | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ILK | PARVG | 0.998 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RSU1 | PXN | 0.985 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PARVB | PXN | 0.981 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ILK | PXN | 0.978 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| LIMS1 | PXN | 0.908 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes