hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06652.1

Complex Portal: CPX-20860

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
WASHC2C	WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)	5	UniProt NCBI
CRACD	Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics)	5	UniProt NCBI
RCSD1	CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1)	5	UniProt NCBI
WASHC5	WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)	5	UniProt NCBI
CARMIL2	Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)	5	UniProt NCBI
PLEKHO2	Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)	3	UniProt NCBI
CAPZA1	F-actin-capping protein subunit alpha-1 (CapZ alpha-1)	5	UniProt NCBI
ARAP1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)	5	UniProt NCBI
CAPZB	F-actin-capping protein subunit beta (CapZ beta)	5	UniProt NCBI
KIAA1671	Uncharacterized protein KIAA1671	2	UniProt NCBI
CPVL	Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)	4	UniProt NCBI
CAPZA2	F-actin-capping protein subunit alpha-2 (CapZ alpha-2)	5	UniProt NCBI
WASHC4	WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)	5	UniProt NCBI
PLEKHO1	Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6484	3.94753678843e-13	0.357142857143	WASHC5 WASHC4 WASHC2C CAPZB CAPZA1	WASH-CAPZalpa/beta complex
GO:0071203	1.89933032265e-11	0.428571428571	WASHC4 CAPZA1 RCSD1 CAPZB WASHC5 WASHC2C	WASH complex
GO:0110053	5.06417153938e-10	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of actin filament organization
GO:0051693	8.22359366445e-10	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	actin filament capping
GO:0051016	8.22359366445e-10	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	barbed-end actin filament capping
GO:0030835	1.94918693799e-09	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of actin filament depolymerization
GO:0032956	5.12197511213e-09	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of actin cytoskeleton organization
GO:0030834	9.94091378428e-09	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of actin filament depolymerization
GO:0032970	1.39082153026e-08	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of actin filament-based process
CORUM:6671	1.9561308074e-08	0.285714285714	WASHC5 WASHC4 CAPZB CAPZA1	PI4K2A-WASH complex
GO:1902903	1.96010266893e-08	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of supramolecular fiber organization
GO:0030042	2.54429684127e-08	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	actin filament depolymerization
GO:0030837	2.54429684127e-08	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of actin filament polymerization
KEGG:04144	3.9099458874e-08	0.5	ARAP1 WASHC4 WASHC2C CAPZA1 CAPZB WASHC5 CAPZA2	Endocytosis
GO:0030041	8.09703896546e-08	0.5	CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	actin filament polymerization
GO:1901880	8.88066455251e-08	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of protein depolymerization
GO:0032272	1.33609192146e-07	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of protein polymerization
GO:0007015	1.49924123315e-07	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	actin filament organization
GO:0051494	1.62509060003e-07	0.5	ARAP1 CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC2C	negative regulation of cytoskeleton organization
GO:1902904	1.73588427501e-07	0.5	ARAP1 CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC2C	negative regulation of supramolecular fiber organization
GO:0043242	3.14594489726e-07	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of protein-containing complex disassembly
GO:0008154	3.44955139348e-07	0.5	CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	actin polymerization or depolymerization
GO:1901879	3.52180038392e-07	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of protein depolymerization
CORUM:6481	3.64803730192e-07	0.214285714286	WASHC5 WASHC2C WASHC4	WASH complex
GO:0051493	4.20862540305e-07	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of cytoskeleton organization
GO:0030833	2.16466200558e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of actin filament polymerization
GO:0051261	3.7519255129e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	protein depolymerization
GO:0008064	5.79030456621e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of actin polymerization or depolymerization
GO:0043244	6.20595448089e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of protein-containing complex disassembly
GO:0030832	7.11188576616e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of actin filament length
GO:0031333	8.6749842154e-06	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	negative regulation of protein-containing complex assembly
GO:0030036	8.78233447882e-06	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	actin cytoskeleton organization
GO:0051258	1.28032662674e-05	0.5	CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	protein polymerization
GO:0030029	2.30824248235e-05	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	actin filament-based process
GO:0097435	2.7986913076e-05	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	supramolecular fiber organization
CORUM:6483	4.44741811353e-05	0.142857142857	CAPZA1 CAPZB	CAPZalpha-CAPZbeta complex
GO:0032271	7.17201697623e-05	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of protein polymerization
GO:0010639	9.66051211119e-05	0.5	ARAP1 CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC2C	negative regulation of organelle organization
GO:2000813	0.000139871762976	0.214285714286	CARMIL2 WASHC2C CRACD	negative regulation of barbed-end actin filament capping
GO:2000812	0.000349481973524	0.214285714286	CARMIL2 WASHC2C CRACD	regulation of barbed-end actin filament capping
GO:0034315	0.000389049485032	0.285714285714	WASHC5 WASHC4 WASHC2C CARMIL2	regulation of Arp2/3 complex-mediated actin nucleation
GO:0032984	0.000740010718571	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	protein-containing complex disassembly
GO:0033043	0.000908105383513	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	regulation of organelle organization
GO:0051125	0.000932727983935	0.285714285714	WASHC5 WASHC4 WASHC2C CARMIL2	regulation of actin nucleation
GO:0032535	0.00108644576497	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of cellular component size
GO:0008290	0.00122180600483	0.214285714286	CAPZA1 CAPZA2 CAPZB	F-actin capping protein complex
CORUM:846	0.00124119242179	0.142857142857	CAPZA1 CAPZB	RICH1/AMOT polarity complex, Flag-Rich1 precipitated
GO:0034314	0.0023600929545	0.285714285714	WASHC5 WASHC4 WASHC2C CARMIL2	Arp2/3 complex-mediated actin nucleation
REAC:R-HSA-6811436	0.00375162166292	0.214285714286	CAPZA1 CAPZA2 CAPZB	COPI-independent Golgi-to-ER retrograde traffic
GO:0045010	0.00383717232873	0.285714285714	WASHC5 WASHC4 WASHC2C CARMIL2	actin nucleation
REAC:R-HSA-9662360	0.00398384566296	0.214285714286	CAPZA1 CAPZA2 CAPZB	Sensory processing of sound by inner hair cells of the cochlea
GO:0090066	0.00398716763164	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of anatomical structure size
GO:0030836	0.00418195709292	0.214285714286	CARMIL2 WASHC2C CRACD	positive regulation of actin filament depolymerization
REAC:R-HSA-3371497	0.00422536563884	0.214285714286	CAPZA1 CAPZA2 CAPZB	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
REAC:R-HSA-9659379	0.00500745031661	0.214285714286	CAPZA1 CAPZA2 CAPZB	Sensory processing of sound
GO:0007010	0.00540172587396	0.642857142857	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 WASHC2C	cytoskeleton organization
GO:0051129	0.00620802686688	0.5	ARAP1 CAPZA2 CARMIL2 CRACD CAPZA1 CAPZB WASHC2C	negative regulation of cellular component organization
GO:0043254	0.00746047974722	0.428571428571	CARMIL2 WASHC2C CAPZA1 CAPZB CAPZA2 CRACD	regulation of protein-containing complex assembly
GO:1901881	0.00995012273459	0.214285714286	CARMIL2 WASHC2C CRACD	positive regulation of protein depolymerization
REAC:R-HSA-879415	0.010724165603	0.142857142857	CAPZA1 CAPZA2	Advanced glycosylation endproduct receptor signaling
GO:0051128	0.014141078785	0.714285714286	ARAP1 CAPZA2 CARMIL2 WASHC4 CRACD CAPZA1 CAPZB WASHC5 PLEKHO1 WASHC2C	regulation of cellular component organization
KEGG:04814	0.0247409017916	0.214285714286	CAPZA1 CAPZA2 CAPZB	Motor proteins
REAC:R-HSA-6807878	0.0266464070762	0.214285714286	CAPZA1 CAPZA2 CAPZB	COPI-mediated anterograde transport
REAC:R-HSA-2132295	0.0479400061023	0.214285714286	CAPZA1 CAPZA2 CAPZB	MHC class II antigen presentation
CORUM:7002	0.0499958217778	0.0714285714286	CAPZB	CAPZA3-CAPZB complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CAPZA1	CAPZB	1.0	0.946	structurally_consistent (dimer)
CAPZA1	PLEKHO2	1.0	0.078	structurally_consistent (dimer)
CAPZB	PLEKHO2	1.0	0.166	mutually_exclusive (P52907)
CAPZB	PLEKHO1	1.0	0.126
WASHC2C	CAPZA2	1.0	0.094
CAPZB	CAPZA2	1.0	0.934	structurally_consistent (dimer)
CAPZA2	WASHC4	1.0	0.226
CAPZA1	PLEKHO1	0.999	0.086	mutually_exclusive (P47755) structurally_consistent (dimer)
CAPZA2	PLEKHO2	0.999	0.1	mutually_exclusive (P52907)
CAPZA2	WASHC5	0.999	0.254
CAPZA1	CAPZA2	0.999	0.72	structurally_consistent (dimer)
CRACD	CAPZB	0.999	0.242
WASHC5	WASHC4	0.999	0.928
CARMIL2	CAPZB	0.998	0.18
KIAA1671	CAPZA2	0.998	0.108	structurally_consistent (dimer)
CARMIL2	CAPZA2	0.998	0.09	structurally_consistent (dimer)
CRACD	CAPZA1	0.998	0.174	structurally_consistent (dimer)
CARMIL2	CAPZA1	0.998	0.082	mutually_exclusive (P47755)
RCSD1	CAPZA2	0.997	0.118	mutually_exclusive (P52907) structurally_consistent (dimer)
CPVL	CAPZB	0.997	0.144
CPVL	CAPZA2	0.997	0.168	mutually_exclusive (O00399)
CRACD	CAPZA2	0.997	0.252	mutually_exclusive (P52907) structurally_consistent (dimer)
WASHC2C	CAPZB	0.997	0.208
RCSD1	CAPZB	0.997	0.052
CAPZA2	PLEKHO1	0.997	0.08	structurally_consistent (dimer)
CAPZA1	CPVL	0.996	0.104
RCSD1	CAPZA1	0.996	0.06	mutually_exclusive (P47755) structurally_consistent (dimer)
CAPZB	KIAA1671	0.994	0.228	mutually_exclusive (P47755)
CAPZA1	KIAA1671	0.993	0.096	mutually_exclusive (P47755)
CAPZB	WASHC4	0.992	0.36
ARAP1	CAPZA2	0.992	0.126
CAPZB	WASHC5	0.991	0.518
WASHC2C	WASHC5	0.991	0.372
WASHC2C	CAPZA1	0.99	0.173050905953
WASHC2C	WASHC4	0.99	0.308	structurally_consistent (dimer)
CAPZA1	WASHC5	0.987	0.24
CAPZA1	WASHC4	0.987	0.184
ARAP1	CAPZB	0.977	0.214
CRACD	WASHC5	0.976	0.068
CARMIL2	WASHC5	0.975	0.026
KIAA1671	WASHC5	0.974	0.022
WASHC2C	PLEKHO2	0.974	0.022
WASHC5	PLEKHO2	0.974	0.04
WASHC4	PLEKHO2	0.974	0.01
CARMIL2	PLEKHO2	0.974	0.014
CARMIL2	WASHC4	0.974	0.022
CPVL	PLEKHO2	0.973	0.028
ARAP1	CAPZA1	0.973	0.116
CRACD	WASHC4	0.972	0.036
WASHC2C	CRACD	0.972	0.11
CRACD	CPVL	0.967	0.142
CRACD	PLEKHO2	0.965	0.064
ARAP1	CRACD	0.965	0.096
CRACD	CARMIL2	0.964	0.076
ARAP1	PLEKHO2	0.961	0.014
ARAP1	WASHC2C	0.961	0.038
ARAP1	WASHC4	0.961	0.096
ARAP1	CARMIL2	0.959	0.04
KIAA1671	PLEKHO2	0.958	0.012
CRACD	KIAA1671	0.958	0.042	mutually_exclusive (P47755)
ARAP1	WASHC5	0.956	0.076
KIAA1671	WASHC4	0.95	0.03
WASHC2C	CARMIL2	0.95	0.028
WASHC2C	KIAA1671	0.935	0.096
CARMIL2	KIAA1671	0.864	0.04	mutually_exclusive (P47755)
ARAP1	KIAA1671	0.864	0.036
CPVL	PLEKHO1	0.834	0.104
PLEKHO1	WASHC5	0.785	0.068
PLEKHO1	PLEKHO2	0.783	0.096	mutually_exclusive (P52907)
CPVL	WASHC5	0.772	0.07
PLEKHO1	WASHC4	0.77	0.098
KIAA1671	PLEKHO1	0.766	0.074	mutually_exclusive (P47755)
ARAP1	PLEKHO1	0.766	0.078
WASHC2C	CPVL	0.67	0.068
CARMIL2	PLEKHO1	0.629	0.124
CRACD	PLEKHO1	0.629	0.102
CARMIL2	CPVL	0.603	0.072
WASHC2C	PLEKHO1	0.594	0.104
CPVL	WASHC4	0.581	0.058
CPVL	KIAA1671	0.203	0.042
ARAP1	CPVL	0.178	0.05

Related Complexes

Genename	Complexes
WASHC2C	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CRACD	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
RCSD1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
WASHC5	huMAP3_05454.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CARMIL2	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
PLEKHO2	huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CAPZA1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
ARAP1	huMAP3_00870.1 huMAP3_06652.1 huMAP3_07569.1 huMAP3_08077.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10500.1 huMAP3_10870.1 huMAP3_12900.1 huMAP3_15054.1
CAPZB	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
KIAA1671	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CPVL	huMAP3_02458.1 huMAP3_02470.1 huMAP3_04946.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_09952.1 huMAP3_10870.1 huMAP3_11730.1 huMAP3_12900.1
CAPZA2	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_09348.1 huMAP3_10870.1 huMAP3_12900.1
WASHC4	huMAP3_05454.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
PLEKHO1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12723.1 huMAP3_12900.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06652.1

Complex Portal: CPX-20860