hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06675.1
Complex Portal: CPX-22296
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FGB | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | 5 | UniProt NCBI |
| FGA | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6417 | 5.12628525639e-06 | 1.0 | FGB FGA | Fibrinogen complex |
| WP:WP4927 | 6.38455527386e-06 | 1.0 | FGB FGA | COVID 19 thrombosis and anticoagulation |
| HP:0034287 | 1.02525705128e-05 | 1.0 | FGB FGA | Afibrinogenemia |
| HP:0400008 | 1.02525705128e-05 | 1.0 | FGB FGA | Menometrorrhagia |
| HP:0012223 | 3.41752350426e-05 | 1.0 | FGB FGA | Splenic rupture |
| HP:0100310 | 3.41752350426e-05 | 1.0 | FGB FGA | Epidural hemorrhage |
| WP:WP272 | 6.51224637934e-05 | 1.0 | FGB FGA | Blood clotting cascade |
| HP:0011884 | 7.17679935894e-05 | 1.0 | FGB FGA | Abnormal umbilical stump bleeding |
| REAC:R-HSA-354194 | 9.39818963671e-05 | 1.0 | FGB FGA | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| REAC:R-HSA-372708 | 0.000112778275641 | 1.0 | FGB FGA | p130Cas linkage to MAPK signaling for integrins |
| HP:0030137 | 0.000123030846153 | 1.0 | FGB FGA | Prolonged bleeding following circumcision |
| REAC:R-HSA-5602498 | 0.000155497319444 | 1.0 | FGB FGA | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5603041 | 0.000155497319444 | 1.0 | FGB FGA | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5686938 | 0.000179419983974 | 1.0 | FGB FGA | Regulation of TLR by endogenous ligand |
| WP:WP4136 | 0.00022473634564 | 1.0 | FGB FGA | Fibrin complement receptor 3 signaling pathway |
| HP:0001934 | 0.000225556551281 | 1.0 | FGB FGA | Persistent bleeding after trauma |
| HP:0100309 | 0.000225556551281 | 1.0 | FGB FGA | Subdural hemorrhage |
| REAC:R-HSA-140875 | 0.00023239159829 | 1.0 | FGB FGA | Common Pathway of Fibrin Clot Formation |
| HP:0006298 | 0.000358839967947 | 1.0 | FGB FGA | Prolonged bleeding after dental extraction |
| REAC:R-HSA-354192 | 0.000358839967947 | 1.0 | FGB FGA | Integrin signaling |
| KEGG:04610 | 0.000403985690766 | 1.0 | FGB FGA | Complement and coagulation cascades |
| HP:0002248 | 0.000410102820511 | 1.0 | FGB FGA | Hematemesis |
| REAC:R-HSA-5260271 | 0.000599775374997 | 1.0 | FGB FGA | Diseases of Immune System |
| REAC:R-HSA-5602358 | 0.000599775374997 | 1.0 | FGB FGA | Diseases associated with the TLR signaling cascade |
| WP:WP176 | 0.000632070972113 | 1.0 | FGB FGA | Folate metabolism |
| REAC:R-HSA-76009 | 0.000645911942305 | 1.0 | FGB FGA | Platelet Aggregation (Plug Formation) |
| HP:0011421 | 0.000649329465809 | 1.0 | FGB FGA | Death in adolescence |
| WP:WP5356 | 0.000679316681139 | 1.0 | FGB FGA | Affected pathways in Duchenne muscular dystrophy |
| REAC:R-HSA-6802948 | 0.000743311362176 | 1.0 | FGB FGA | Signaling by high-kinase activity BRAF mutants |
| KEGG:04611 | 0.000772693757832 | 1.0 | FGB FGA | Platelet activation |
| REAC:R-HSA-140877 | 0.00079457421474 | 1.0 | FGB FGA | Formation of Fibrin Clot (Clotting Cascade) |
| HP:0011890 | 0.000864633446577 | 1.0 | FGB FGA | Prolonged bleeding following procedure |
| HP:0005268 | 0.000943236487175 | 1.0 | FGB FGA | Miscarriage |
| REAC:R-HSA-5674135 | 0.000958615342944 | 1.0 | FGB FGA | MAP2K and MAPK activation |
| WP:WP15 | 0.000969601127591 | 1.0 | FGB FGA | Selenium micronutrient network |
| REAC:R-HSA-9656223 | 0.00101671324252 | 1.0 | FGB FGA | Signaling by RAF1 mutants |
| REAC:R-HSA-9649948 | 0.00120125951175 | 1.0 | FGB FGA | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.00120125951175 | 1.0 | FGB FGA | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.00120125951175 | 1.0 | FGB FGA | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 0.00120125951175 | 1.0 | FGB FGA | Signaling by moderate kinase activity BRAF mutants |
| WP:WP2806 | 0.00124541391542 | 1.0 | FGB FGA | Complement system |
| KEGG:04613 | 0.00179249345126 | 1.0 | FGB FGA | Neutrophil extracellular trap formation |
| HP:0011900 | 0.00215303980768 | 1.0 | FGB FGA | Hypofibrinogenemia |
| HP:0011898 | 0.00227607065384 | 1.0 | FGB FGA | Abnormality of circulating fibrinogen |
| REAC:R-HSA-6802952 | 0.00263149309828 | 1.0 | FGB FGA | Signaling by BRAF and RAF1 fusions |
| HP:0001386 | 0.00266566833332 | 1.0 | FGB FGA | Joint swelling |
| GO:0043152 | 0.0028092043205 | 1.0 | FGB FGA | induction of bacterial agglutination |
| KEGG:05171 | 0.0033003273675 | 1.0 | FGB FGA | Coronavirus disease - COVID-19 |
| REAC:R-HSA-216083 | 0.00333721170191 | 1.0 | FGB FGA | Integrin cell surface interactions |
| HP:0000225 | 0.00353713682691 | 1.0 | FGB FGA | Gingival bleeding |
| REAC:R-HSA-6802957 | 0.00424627295404 | 1.0 | FGB FGA | Oncogenic MAPK signaling |
| HP:0034241 | 0.00453163616665 | 1.0 | FGB FGA | Prenatal death |
| HP:0010990 | 0.00526298619656 | 1.0 | FGB FGA | Abnormality of the common coagulation pathway |
| HP:0001342 | 0.0054543675128 | 1.0 | FGB FGA | Cerebral hemorrhage |
| REAC:R-HSA-1236974 | 0.0061002794551 | 1.0 | FGB FGA | ER-Phagosome pathway |
| WP:WP5115 | 0.00618663406037 | 1.0 | FGB FGA | Network map of SARS CoV 2 signaling pathway |
| HP:0004936 | 0.00688972738458 | 1.0 | FGB FGA | Venous thrombosis |
| REAC:R-HSA-168188 | 0.00762962122326 | 1.0 | FGB FGA | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00762962122326 | 1.0 | FGB FGA | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168179 | 0.00795599471791 | 1.0 | FGB FGA | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.00795599471791 | 1.0 | FGB FGA | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-1236975 | 0.00812174460787 | 1.0 | FGB FGA | Antigen processing-Cross presentation |
| REAC:R-HSA-114608 | 0.00932983916662 | 1.0 | FGB FGA | Platelet degranulation |
| GO:0005577 | 0.00983221512175 | 1.0 | FGB FGA | fibrinogen complex |
| REAC:R-HSA-76005 | 0.010244026704 | 1.0 | FGB FGA | Response to elevated platelet cytosolic Ca2+ |
| HP:0000421 | 0.0102628230833 | 1.0 | FGB FGA | Epistaxis |
| HP:0003811 | 0.0113495955576 | 1.0 | FGB FGA | Neonatal death |
| REAC:R-HSA-166016 | 0.0128208394262 | 1.0 | FGB FGA | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0045907 | 0.0131096201623 | 1.0 | FGB FGA | positive regulation of vasoconstriction |
| REAC:R-HSA-168898 | 0.0171064139006 | 1.0 | FGB FGA | Toll-like Receptor Cascades |
| HP:0003819 | 0.020488053408 | 1.0 | FGB FGA | Death in childhood |
| GO:0072378 | 0.0210690324038 | 1.0 | FGB FGA | blood coagulation, fibrin clot formation |
| HP:0003256 | 0.0252247409849 | 1.0 | FGB FGA | Abnormality of the coagulation cascade |
| GO:0072376 | 0.0257510396046 | 1.0 | FGB FGA | protein activation cascade |
| HP:0002170 | 0.0291002126388 | 1.0 | FGB FGA | Intracranial hemorrhage |
| GO:0034116 | 0.0309012475255 | 1.0 | FGB FGA | positive regulation of heterotypic cell-cell adhesion |
| WP:WP3888 | 0.0309740314556 | 1.0 | FGB FGA | VEGFA VEGFR2 signaling |
| HP:0002239 | 0.0318376489657 | 1.0 | FGB FGA | Gastrointestinal hemorrhage |
| HP:0000978 | 0.0371758206793 | 1.0 | FGB FGA | Bruising susceptibility |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | FGB FGA | RAF/MAP kinase cascade |
| REAC:R-HSA-76002 | 0.0400465404229 | 1.0 | FGB FGA | Platelet activation, signaling and aggregation |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | FGB FGA | MAPK1/MAPK3 signaling |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | FGB FGA | Extracellular matrix organization |
| HP:0001977 | 0.0451215628267 | 1.0 | FGB FGA | Abnormal thrombosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FGB | FGA | 0.984 | 0.312 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM |
Related Complexes