hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06676.1
Complex Portal: CPX-11764
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFNGR1 | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | 5 | UniProt NCBI |
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | 5 | UniProt NCBI |
| UGCG | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | 5 | UniProt NCBI |
| PTPRS | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) | 5 | UniProt NCBI |
| NDFIP1 | NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein) | 5 | UniProt NCBI |
| IL20RB | Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2) | 5 | UniProt NCBI |
| SYT11 | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) | 5 | UniProt NCBI |
| KCNE4 | Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3) | 5 | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04061 | 0.000162137358357 | 0.375 | TNFRSF10A IL20RB TNFRSF10B | Viral protein interaction with cytokine and cytokine receptor |
| REAC:R-HSA-75158 | 0.00116989543065 | 0.25 | TNFRSF10A TNFRSF10B | TRAIL signaling |
| REAC:R-HSA-5218900 | 0.00250486048439 | 0.25 | TNFRSF10A TNFRSF10B | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 0.00250486048439 | 0.25 | TNFRSF10A TNFRSF10B | Dimerization of procaspase-8 |
| REAC:R-HSA-3371378 | 0.00250486048439 | 0.25 | TNFRSF10A TNFRSF10B | Regulation by c-FLIP |
| REAC:R-HSA-6803211 | 0.00367178411278 | 0.25 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-140534 | 0.00433819320746 | 0.25 | TNFRSF10A TNFRSF10B | Caspase activation via Death Receptors in the presence of ligand |
| KEGG:04060 | 0.00636183316424 | 0.375 | TNFRSF10A IL20RB TNFRSF10B | Cytokine-cytokine receptor interaction |
| REAC:R-HSA-5357769 | 0.00949504138694 | 0.25 | TNFRSF10A TNFRSF10B | Caspase activation via extrinsic apoptotic signalling pathway |
| GO:0045569 | 0.0131096201623 | 0.25 | TNFRSF10A TNFRSF10B | TRAIL binding |
| REAC:R-HSA-5213460 | 0.0240813966337 | 0.25 | TNFRSF10A TNFRSF10B | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.0240813966337 | 0.25 | TNFRSF10A TNFRSF10B | Regulation of necroptotic cell death |
| KEGG:04115 | 0.0257266913769 | 0.25 | TNFRSF10A TNFRSF10B | p53 signaling pathway |
| REAC:R-HSA-5633008 | 0.0388325640363 | 0.25 | TNFRSF10A TNFRSF10B | TP53 Regulates Transcription of Cell Death Genes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDFIP1 | UGCG | 0.995 | 0.078 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTPRS | KCNE4 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | UGCG | 0.991 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTPRS | IL20RB | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | TNFRSF10A | 0.986 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NDFIP1 | KCNE4 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NDFIP1 | IFNGR1 | 0.981 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TNFRSF10B | NDFIP1 | 0.98 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTPRS | SYT11 | 0.98 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TNFRSF10B | IFNGR1 | 0.978 | 0.126571428571 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| TNFRSF10B | IL20RB | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | KCNE4 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | SYT11 | 0.963 | 0.066 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IFNGR1 | UGCG | 0.953 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| TNFRSF10A | UGCG | 0.953 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TNFRSF10B | PTPRS | 0.951 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| NDFIP1 | PTPRS | 0.936 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRS | IFNGR1 | 0.928 | 0.194 | bioplex_WMM bioplex3_WMM WMM_only | |
| TNFRSF10A | IFNGR1 | 0.924 | 0.128 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NDFIP1 | TNFRSF10A | 0.899 | 0.084 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PTPRS | UGCG | 0.88 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRS | TNFRSF10A | 0.546 | 0.09 | bioplex () bioplex_WMM bioplex3_WMM | |
| IL20RB | IFNGR1 | 0.101 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes