hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
PDE4D	3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)	5	UniProt NCBI
PDE4A	3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP5294	7.2783930122e-05	1.0	PDE4D PDE4A	Sildenafil treatment
WP:WP4222	0.000299222823835	1.0	PDE4D PDE4A	Phosphodiesterases in neuronal function
REAC:R-HSA-180024	0.000324664732905	1.0	PDE4D PDE4A	DARPP-32 events
KEGG:05032	0.00037033376401	1.0	PDE4D PDE4A	Morphine addiction
KEGG:04928	0.000553224670293	1.0	PDE4D PDE4A	Parathyroid hormone synthesis, secretion and action
KEGG:00230	0.000772693757832	1.0	PDE4D PDE4A	Purine metabolism
WP:WP35	0.00127818796583	1.0	PDE4D PDE4A	G protein signaling pathways
KEGG:04024	0.00201635192055	1.0	PDE4D PDE4A	cAMP signaling pathway
REAC:R-HSA-111885	0.00513141154164	1.0	PDE4D PDE4A	Opioid Signalling
REAC:R-HSA-418555	0.00715287669441	1.0	PDE4D PDE4A	G alpha (s) signalling events
GO:0030552	0.0257510396046	1.0	PDE4D PDE4A	cAMP binding
REAC:R-HSA-418594	0.0293992459454	1.0	PDE4D PDE4A	G alpha (i) signalling events
GO:0004115	0.0309012475255	1.0	PDE4D PDE4A	3',5'-cyclic-AMP phosphodiesterase activity
CORUM:518	0.0499419797295	0.5	PDE4D	AKAP250-PKA-PDE4D complex

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PDE4D	PDE4A	0.997		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only

Genename	Complexes
PDE4D	huMAP3_02425.1 huMAP3_04060.1 huMAP3_06687.1 huMAP3_14765.1 huMAP3_14977.1
PDE4A	huMAP3_02425.1 huMAP3_06306.1 huMAP3_06687.1 huMAP3_11340.1 huMAP3_12065.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_14847.1 huMAP3_14977.1