hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06687.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | 5 | UniProt NCBI |
| PDE4A | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5294 | 7.2783930122e-05 | 1.0 | PDE4D PDE4A | Sildenafil treatment |
| WP:WP4222 | 0.000299222823835 | 1.0 | PDE4D PDE4A | Phosphodiesterases in neuronal function |
| REAC:R-HSA-180024 | 0.000324664732905 | 1.0 | PDE4D PDE4A | DARPP-32 events |
| KEGG:05032 | 0.00037033376401 | 1.0 | PDE4D PDE4A | Morphine addiction |
| KEGG:04928 | 0.000553224670293 | 1.0 | PDE4D PDE4A | Parathyroid hormone synthesis, secretion and action |
| KEGG:00230 | 0.000772693757832 | 1.0 | PDE4D PDE4A | Purine metabolism |
| WP:WP35 | 0.00127818796583 | 1.0 | PDE4D PDE4A | G protein signaling pathways |
| KEGG:04024 | 0.00201635192055 | 1.0 | PDE4D PDE4A | cAMP signaling pathway |
| REAC:R-HSA-111885 | 0.00513141154164 | 1.0 | PDE4D PDE4A | Opioid Signalling |
| REAC:R-HSA-418555 | 0.00715287669441 | 1.0 | PDE4D PDE4A | G alpha (s) signalling events |
| GO:0030552 | 0.0257510396046 | 1.0 | PDE4D PDE4A | cAMP binding |
| REAC:R-HSA-418594 | 0.0293992459454 | 1.0 | PDE4D PDE4A | G alpha (i) signalling events |
| GO:0004115 | 0.0309012475255 | 1.0 | PDE4D PDE4A | 3',5'-cyclic-AMP phosphodiesterase activity |
| CORUM:518 | 0.0499419797295 | 0.5 | PDE4D | AKAP250-PKA-PDE4D complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE4D | PDE4A | 0.997 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes