hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06706.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PCMTD1	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1	5	UniProt NCBI
TULP4	Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)	5	UniProt NCBI
SOCS2	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)	5	UniProt NCBI
PCMTD2	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	5	UniProt NCBI
SOCS5	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)	5	UniProt NCBI
SOCS4	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)	5	UniProt NCBI
RNF7	RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)	5	UniProt NCBI
LRRC28	Leucine-rich repeat-containing protein 28	2	UniProt NCBI
SOCS7	Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)	5	UniProt NCBI
ASB13	Ankyrin repeat and SOCS box protein 13 (ASB-13)	5	UniProt NCBI
WSB1	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)	5	UniProt NCBI
CUL5	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	5	UniProt NCBI
ASB1	Ankyrin repeat and SOCS box protein 1 (ASB-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8951664	9.17240818019e-10	0.615384615385	WSB1 RNF7 TULP4 CUL5 ASB13 ASB1 SOCS5 SOCS2	Neddylation
CORUM:208	3.08563128138e-07	0.230769230769	RNF7 CUL5 ASB1	Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
KEGG:04917	1.16692731435e-05	0.307692307692	SOCS5 SOCS2 SOCS7 SOCS4	Prolactin signaling pathway
GO:0046935	1.87397331349e-05	0.307692307692	SOCS5 SOCS2 SOCS7 SOCS4	1-phosphatidylinositol-3-kinase regulator activity
GO:0005942	0.00023553955807	0.307692307692	SOCS5 SOCS2 SOCS7 SOCS4	phosphatidylinositol 3-kinase complex
KEGG:04630	0.000236871836576	0.307692307692	SOCS5 SOCS2 SOCS7 SOCS4	JAK-STAT signaling pathway
CORUM:211	0.000245952888523	0.153846153846	RNF7 CUL5	Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
CORUM:210	0.00040971577212	0.153846153846	RNF7 CUL5	Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
CORUM:209	0.00040971577212	0.153846153846	RNF7 CUL5	Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
CORUM:207	0.00040971577212	0.153846153846	RNF7 CUL5	Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
CORUM:214	0.00040971577212	0.153846153846	WSB1 CUL5	Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
REAC:R-HSA-597592	0.000596742367683	0.615384615385	WSB1 RNF7 TULP4 CUL5 ASB13 ASB1 SOCS5 SOCS2	Post-translational protein modification
REAC:R-HSA-983168	0.000799668094978	0.384615384615	CUL5 RNF7 ASB1 WSB1 ASB13	Antigen processing: Ubiquitination & Proteasome degradation
REAC:R-HSA-983169	0.00217297940146	0.384615384615	CUL5 RNF7 ASB1 WSB1 ASB13	Class I MHC mediated antigen processing & presentation
GO:0031466	0.00230208510773	0.230769230769	PCMTD1 CUL5 RNF7	Cul5-RING ubiquitin ligase complex
GO:1990234	0.00312395380616	0.615384615385	PCMTD1 CUL5 SOCS7 ASB1 SOCS4 RNF7 SOCS5 SOCS2	transferase complex
GO:0046854	0.00328524790479	0.307692307692	SOCS5 SOCS2 SOCS7 SOCS4	phosphatidylinositol phosphate biosynthetic process
REAC:R-HSA-392499	0.00699660503832	0.615384615385	WSB1 RNF7 TULP4 CUL5 ASB13 ASB1 SOCS5 SOCS2	Metabolism of proteins
HPA:0130052	0.00736938220116	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	colon; glandular cells[>=Medium]
HPA:0150052	0.00904135749212	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	duodenum; glandular cells[>=Medium]
HPA:0030051	0.026586604905	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	appendix; glandular cells[>=Low]
HPA:0080000	0.0332127789767	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	caudate
KEGG:04930	0.0335992051794	0.153846153846	SOCS2 SOCS4	Type II diabetes mellitus
HPA:0030052	0.0356518520066	0.846153846154	RNF7 LRRC28 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	appendix; glandular cells[>=Medium]
HPA:0130051	0.0380257454833	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	colon; glandular cells[>=Low]
HPA:0480051	0.0430670798513	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	small intestine; glandular cells[>=Low]
HPA:0150051	0.0448228988718	0.923076923077	RNF7 LRRC28 SOCS7 CUL5 PCMTD1 TULP4 SOCS2 ASB13 SOCS4 SOCS5 PCMTD2 WSB1	duodenum; glandular cells[>=Low]
REAC:R-HSA-1280218	0.0494405351283	0.384615384615	CUL5 RNF7 ASB1 WSB1 ASB13	Adaptive Immune System
REAC:R-HSA-9705462	0.0499595654642	0.153846153846	RNF7 CUL5	Inactivation of CSF3 (G-CSF) signaling

Edges

Protein 1	Protein 2	Score	ProteomeHD
RNF7	CUL5	1.0	0.544
SOCS2	CUL5	0.999
TULP4	CUL5	0.999
SOCS7	CUL5	0.998
SOCS5	CUL5	0.998
ASB1	CUL5	0.998	0.096
LRRC28	CUL5	0.998
WSB1	CUL5	0.997
SOCS4	CUL5	0.997
RNF7	SOCS2	0.997
SOCS5	RNF7	0.997
ASB1	RNF7	0.997	0.138
ASB13	RNF7	0.997
WSB1	RNF7	0.997
SOCS4	RNF7	0.997
SOCS7	RNF7	0.995
ASB13	CUL5	0.993
PCMTD1	CUL5	0.991	0.034
RNF7	PCMTD1	0.99	0.082
PCMTD2	RNF7	0.98	0.128
PCMTD2	CUL5	0.976	0.06
TULP4	RNF7	0.974
PCMTD2	PCMTD1	0.941	0.136
WSB1	SOCS2	0.925
ASB13	SOCS5	0.925
SOCS4	SOCS2	0.925
ASB13	SOCS4	0.925
ASB13	WSB1	0.925
SOCS5	SOCS2	0.925
ASB13	SOCS7	0.918
WSB1	SOCS5	0.913
SOCS5	SOCS4	0.913
WSB1	SOCS4	0.913
SOCS7	WSB1	0.913
SOCS7	SOCS4	0.913
SOCS7	SOCS5	0.913
ASB13	SOCS2	0.912
SOCS5	LRRC28	0.877
WSB1	LRRC28	0.877
SOCS4	LRRC28	0.877
SOCS7	LRRC28	0.868
ASB13	LRRC28	0.868
LRRC28	SOCS2	0.868
SOCS7	SOCS2	0.861
ASB13	ASB1	0.844
ASB1	SOCS4	0.841
ASB1	WSB1	0.841
ASB1	SOCS5	0.841
ASB1	SOCS2	0.823
TULP4	SOCS4	0.821
WSB1	TULP4	0.821
SOCS5	TULP4	0.821
ASB1	PCMTD2	0.816	0.076
PCMTD1	SOCS2	0.802
ASB13	TULP4	0.8
ASB1	SOCS7	0.799
SOCS7	PCMTD1	0.795
TULP4	SOCS2	0.786
PCMTD2	WSB1	0.785
PCMTD2	SOCS4	0.785
PCMTD2	SOCS5	0.785
ASB13	PCMTD2	0.783
WSB1	PCMTD1	0.778
SOCS5	PCMTD1	0.778
SOCS4	PCMTD1	0.778
SOCS7	TULP4	0.775
ASB13	PCMTD1	0.763
ASB1	TULP4	0.754
ASB1	PCMTD1	0.745	0.074
RNF7	LRRC28	0.741
ASB1	LRRC28	0.741
TULP4	LRRC28	0.716
SOCS7	PCMTD2	0.714
PCMTD2	TULP4	0.685
PCMTD2	LRRC28	0.68
LRRC28	PCMTD1	0.644
TULP4	PCMTD1	0.512
PCMTD2	SOCS2	0.356

Related Complexes

Genename	Complexes
PCMTD1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
TULP4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
PCMTD2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
SOCS5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
RNF7	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
LRRC28	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS7	huMAP3_03653.1 huMAP3_04750.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB13	huMAP3_01436.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_06301.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09431.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
WSB1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
CUL5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB1	huMAP3_01555.1 huMAP3_02310.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_05980.1 huMAP3_06706.1 huMAP3_07874.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_12652.1 huMAP3_13601.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06706.1