hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06706.1
Complex Portal: CPX-15225
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCMTD1 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 | 5 | UniProt NCBI |
| TULP4 | Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) | 5 | UniProt NCBI |
| SOCS2 | Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2) | 5 | UniProt NCBI |
| PCMTD2 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 | 5 | UniProt NCBI |
| SOCS5 | Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5) | 5 | UniProt NCBI |
| SOCS4 | Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7) | 5 | UniProt NCBI |
| RNF7 | RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) | 5 | UniProt NCBI |
| LRRC28 | Leucine-rich repeat-containing protein 28 | 2 | UniProt NCBI |
| SOCS7 | Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4) | 5 | UniProt NCBI |
| ASB13 | Ankyrin repeat and SOCS box protein 13 (ASB-13) | 5 | UniProt NCBI |
| WSB1 | WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) | 5 | UniProt NCBI |
| CUL5 | Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) | 5 | UniProt NCBI |
| ASB1 | Ankyrin repeat and SOCS box protein 1 (ASB-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951664 | 9.17240818019e-10 | 0.615384615385 | WSB1 TULP4 CUL5 ASB13 RNF7 SOCS5 SOCS2 ASB1 | Neddylation |
| CORUM:208 | 3.08563128138e-07 | 0.230769230769 | CUL5 RNF7 ASB1 | Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) |
| KEGG:04917 | 1.16692731435e-05 | 0.307692307692 | SOCS5 SOCS7 SOCS2 SOCS4 | Prolactin signaling pathway |
| GO:0046935 | 1.87397331349e-05 | 0.307692307692 | SOCS5 SOCS7 SOCS2 SOCS4 | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:0005942 | 0.00023553955807 | 0.307692307692 | SOCS5 SOCS7 SOCS2 SOCS4 | phosphatidylinositol 3-kinase complex |
| KEGG:04630 | 0.000236871836576 | 0.307692307692 | SOCS5 SOCS7 SOCS2 SOCS4 | JAK-STAT signaling pathway |
| CORUM:211 | 0.000245952888523 | 0.153846153846 | CUL5 RNF7 | Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:210 | 0.00040971577212 | 0.153846153846 | CUL5 RNF7 | Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:209 | 0.00040971577212 | 0.153846153846 | CUL5 RNF7 | Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:207 | 0.00040971577212 | 0.153846153846 | CUL5 RNF7 | Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:214 | 0.00040971577212 | 0.153846153846 | WSB1 CUL5 | Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) |
| REAC:R-HSA-597592 | 0.000596742367683 | 0.615384615385 | WSB1 TULP4 CUL5 ASB13 RNF7 SOCS5 SOCS2 ASB1 | Post-translational protein modification |
| REAC:R-HSA-983168 | 0.000799668094978 | 0.384615384615 | ASB13 CUL5 RNF7 ASB1 WSB1 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 0.00217297940146 | 0.384615384615 | ASB13 CUL5 RNF7 ASB1 WSB1 | Class I MHC mediated antigen processing & presentation |
| GO:0031466 | 0.00230208510773 | 0.230769230769 | CUL5 PCMTD1 RNF7 | Cul5-RING ubiquitin ligase complex |
| GO:1990234 | 0.00312395380616 | 0.615384615385 | CUL5 SOCS7 SOCS4 RNF7 ASB1 SOCS5 SOCS2 PCMTD1 | transferase complex |
| GO:0046854 | 0.00328524790479 | 0.307692307692 | SOCS5 SOCS7 SOCS2 SOCS4 | phosphatidylinositol phosphate biosynthetic process |
| REAC:R-HSA-392499 | 0.00699660503832 | 0.615384615385 | WSB1 TULP4 CUL5 ASB13 RNF7 SOCS5 SOCS2 ASB1 | Metabolism of proteins |
| HPA:0130052 | 0.00736938220116 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | colon; glandular cells[>=Medium] |
| HPA:0150052 | 0.00904135749212 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | duodenum; glandular cells[>=Medium] |
| HPA:0030051 | 0.026586604905 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | appendix; glandular cells[>=Low] |
| HPA:0080000 | 0.0332127789767 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | caudate |
| KEGG:04930 | 0.0335992051794 | 0.153846153846 | SOCS4 SOCS2 | Type II diabetes mellitus |
| HPA:0030052 | 0.0356518520066 | 0.846153846154 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS2 TULP4 | appendix; glandular cells[>=Medium] |
| HPA:0130051 | 0.0380257454833 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | colon; glandular cells[>=Low] |
| HPA:0480051 | 0.0430670798513 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | small intestine; glandular cells[>=Low] |
| HPA:0150051 | 0.0448228988718 | 0.923076923077 | WSB1 LRRC28 PCMTD1 CUL5 SOCS4 RNF7 PCMTD2 SOCS5 ASB13 SOCS7 SOCS2 TULP4 | duodenum; glandular cells[>=Low] |
| REAC:R-HSA-1280218 | 0.0494405351283 | 0.384615384615 | ASB13 CUL5 RNF7 ASB1 WSB1 | Adaptive Immune System |
| REAC:R-HSA-9705462 | 0.0499595654642 | 0.153846153846 | CUL5 RNF7 | Inactivation of CSF3 (G-CSF) signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| RNF7 | CUL5 | 1.0 | 0.544 |
structurally_consistent (dimer)
|
| SOCS2 | CUL5 | 0.999 |
structurally_consistent (dimer)
|
|
| TULP4 | CUL5 | 0.999 | ||
| SOCS7 | CUL5 | 0.998 | ||
| SOCS5 | CUL5 | 0.998 |
mutually_exclusive (Q15369)
|
|
| ASB1 | CUL5 | 0.998 | 0.096 | |
| LRRC28 | CUL5 | 0.998 | ||
| WSB1 | CUL5 | 0.997 | ||
| SOCS4 | CUL5 | 0.997 |
structurally_consistent (dimer)
|
|
| RNF7 | SOCS2 | 0.997 |
mutually_exclusive (Q93034)
|
|
| SOCS5 | RNF7 | 0.997 | ||
| ASB1 | RNF7 | 0.997 | 0.138 | |
| ASB13 | RNF7 | 0.997 | ||
| WSB1 | RNF7 | 0.997 | ||
| SOCS4 | RNF7 | 0.997 |
structurally_consistent (Q93034)
|
|
| SOCS7 | RNF7 | 0.995 | ||
| ASB13 | CUL5 | 0.993 | ||
| PCMTD1 | CUL5 | 0.991 | 0.034 | |
| RNF7 | PCMTD1 | 0.99 | 0.082 | |
| PCMTD2 | RNF7 | 0.98 | 0.128 | |
| PCMTD2 | CUL5 | 0.976 | 0.06 | |
| TULP4 | RNF7 | 0.974 | ||
| PCMTD2 | PCMTD1 | 0.941 | 0.136 | |
| ASB13 | SOCS5 | 0.925 | ||
| ASB13 | SOCS4 | 0.925 | ||
| SOCS4 | SOCS2 | 0.925 |
mutually_exclusive (Q15369)
|
|
| SOCS5 | SOCS2 | 0.925 |
mutually_exclusive (Q15369)
|
|
| ASB13 | WSB1 | 0.925 | ||
| WSB1 | SOCS2 | 0.925 |
mutually_exclusive (Q15369)
|
|
| ASB13 | SOCS7 | 0.918 | ||
| SOCS7 | SOCS4 | 0.913 | ||
| SOCS7 | WSB1 | 0.913 | ||
| SOCS7 | SOCS5 | 0.913 | ||
| WSB1 | SOCS5 | 0.913 |
mutually_exclusive (Q15369)
|
|
| SOCS5 | SOCS4 | 0.913 |
mutually_exclusive (Q15369)
|
|
| WSB1 | SOCS4 | 0.913 |
mutually_exclusive (Q15369)
|
|
| ASB13 | SOCS2 | 0.912 | ||
| SOCS4 | LRRC28 | 0.877 | ||
| WSB1 | LRRC28 | 0.877 | ||
| SOCS5 | LRRC28 | 0.877 | ||
| ASB13 | LRRC28 | 0.868 | ||
| SOCS7 | LRRC28 | 0.868 | ||
| LRRC28 | SOCS2 | 0.868 | ||
| SOCS7 | SOCS2 | 0.861 | ||
| ASB13 | ASB1 | 0.844 | ||
| ASB1 | SOCS4 | 0.841 |
mutually_exclusive (Q15369)
|
|
| ASB1 | WSB1 | 0.841 |
mutually_exclusive (Q15369)
|
|
| ASB1 | SOCS5 | 0.841 |
mutually_exclusive (Q15369)
|
|
| ASB1 | SOCS2 | 0.823 |
mutually_exclusive (Q15369)
|
|
| WSB1 | TULP4 | 0.821 | ||
| SOCS5 | TULP4 | 0.821 | ||
| TULP4 | SOCS4 | 0.821 | ||
| ASB1 | PCMTD2 | 0.816 | 0.076 | |
| PCMTD1 | SOCS2 | 0.802 | ||
| ASB13 | TULP4 | 0.8 | ||
| ASB1 | SOCS7 | 0.799 | ||
| SOCS7 | PCMTD1 | 0.795 | ||
| TULP4 | SOCS2 | 0.786 | ||
| PCMTD2 | SOCS4 | 0.785 | ||
| PCMTD2 | WSB1 | 0.785 | ||
| PCMTD2 | SOCS5 | 0.785 | ||
| ASB13 | PCMTD2 | 0.783 | ||
| SOCS4 | PCMTD1 | 0.778 | ||
| SOCS5 | PCMTD1 | 0.778 | ||
| WSB1 | PCMTD1 | 0.778 | ||
| SOCS7 | TULP4 | 0.775 | ||
| ASB13 | PCMTD1 | 0.763 | ||
| ASB1 | TULP4 | 0.754 | ||
| ASB1 | PCMTD1 | 0.745 | 0.074 | |
| ASB1 | LRRC28 | 0.741 | ||
| RNF7 | LRRC28 | 0.741 | ||
| TULP4 | LRRC28 | 0.716 | ||
| SOCS7 | PCMTD2 | 0.714 | ||
| PCMTD2 | TULP4 | 0.685 | ||
| PCMTD2 | LRRC28 | 0.68 | ||
| LRRC28 | PCMTD1 | 0.644 | ||
| TULP4 | PCMTD1 | 0.512 | ||
| PCMTD2 | SOCS2 | 0.356 |
Related Complexes