hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06728.1

Complex Portal: CPX-19326

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
GATAD2B	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	5	UniProt NCBI
RBBP4	Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)	5	UniProt NCBI
SMARCA1	Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)	5	UniProt NCBI
BPTF	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	5	UniProt NCBI
CHD5	Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)	5	UniProt NCBI
ZBTB2	Zinc finger and BTB domain-containing protein 2	5	UniProt NCBI
RBBP7	Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)	5	UniProt NCBI
PWWP2B	PWWP domain-containing protein 2B	5	UniProt NCBI
ZNF512B	Zinc finger protein 512B	5	UniProt NCBI
SHPRH	E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:919	1.31072783286e-08	0.333333333333	RBBP7 RBBP4 BPTF	hNURF complex
CORUM:100	1.31072783286e-08	0.333333333333	RBBP7 RBBP4 BPTF	hNURF complex
CORUM:685	1.0989783268e-06	0.333333333333	GATAD2B RBBP4 RBBP7	MeCP1 complex
CORUM:659	1.0989783268e-06	0.333333333333	GATAD2B RBBP4 RBBP7	MeCP1 complex
GO:0016581	4.51189669214e-06	0.444444444444	GATAD2B RBBP7 RBBP4 CHD5	NuRD complex
GO:0090545	4.51189669214e-06	0.444444444444	GATAD2B RBBP7 RBBP4 CHD5	CHD-type complex
KEGG:03082	1.49968945505e-05	0.444444444444	GATAD2B RBBP7 RBBP4 BPTF	ATP-dependent chromatin remodeling
GO:0070603	5.4694944351e-05	0.555555555556	CHD5 GATAD2B RBBP7 RBBP4 BPTF	SWI/SNF superfamily-type complex
REAC:R-HSA-6804758	0.000154071905864	0.333333333333	GATAD2B RBBP4 RBBP7	Regulation of TP53 Activity through Acetylation
CORUM:3048	0.000273361732609	0.222222222222	RBBP4 RBBP7	mSin3A complex
CORUM:105	0.000273361732609	0.222222222222	RBBP4 RBBP7	Polycomb repressive complex 2 (PRC 2)
CORUM:889	0.000273361732609	0.222222222222	RBBP4 RBBP7	MTA1-HDAC core complex
GO:0016589	0.000282244947588	0.333333333333	RBBP7 RBBP4 BPTF	NURF complex
CORUM:886	0.000409911647195	0.222222222222	RBBP4 RBBP7	MTA1 complex
GO:1904949	0.000442390174864	0.555555555556	CHD5 GATAD2B RBBP7 RBBP4 BPTF	ATPase complex
CORUM:61	0.000573693030134	0.222222222222	RBBP4 RBBP7	Mi2/NuRD complex
CORUM:283	0.000573693030134	0.222222222222	RBBP4 RBBP7	Sin3 complex
CORUM:596	0.000573693030134	0.222222222222	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
CORUM:732	0.000573693030134	0.222222222222	RBBP4 RBBP7	SIN3 complex
CORUM:54	0.000573693030134	0.222222222222	RBBP4 RBBP7	SIN3 complex
CORUM:650	0.000573693030134	0.222222222222	RBBP4 RBBP7	HDAC2-asscociated core complex
CORUM:698	0.000573693030134	0.222222222222	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
CORUM:695	0.000573693030134	0.222222222222	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
REAC:R-HSA-73762	0.00061212143341	0.333333333333	GATAD2B RBBP4 RBBP7	RNA Polymerase I Transcription Initiation
CORUM:696	0.000764679747525	0.222222222222	RBBP4 RBBP7	BRMS1-SIN3-HDAC complex
CORUM:591	0.000764679747525	0.222222222222	RBBP4 RBBP7	SAP complex (Sin3-associated protein complex)
CORUM:587	0.000764679747525	0.222222222222	RBBP4 RBBP7	NuRD.1 complex
CORUM:888	0.000764679747525	0.222222222222	RBBP4 RBBP7	MTA2 complex
CORUM:62	0.000764679747525	0.222222222222	RBBP4 RBBP7	MeCP1 complex
CORUM:649	0.000982845681582	0.222222222222	RBBP4 RBBP7	HDAC1-associated core complex cII
CORUM:646	0.000982845681582	0.222222222222	RBBP4 RBBP7	HDAC1-associated protein complex
CORUM:738	0.000982845681582	0.222222222222	RBBP4 RBBP7	SIN3-ING1b complex I
CORUM:592	0.000982845681582	0.222222222222	RBBP4 RBBP7	SAP complex (Sin3-associated protein complex)
REAC:R-HSA-8943724	0.00110117172447	0.333333333333	GATAD2B RBBP4 RBBP7	Regulation of PTEN gene transcription
CORUM:743	0.00122816473062	0.222222222222	RBBP4 RBBP7	SIN3-SAP25 complex
CORUM:691	0.00122816473062	0.222222222222	RBBP4 RBBP7	SIN3-SAP25 complex
CORUM:2851	0.00150061080904	0.222222222222	RBBP4 RBBP7	ING2 complex
GO:0006338	0.00151682515625	0.666666666667	RBBP7 PWWP2B GATAD2B RBBP4 CHD5 BPTF	chromatin remodeling
REAC:R-HSA-427389	0.00156460058052	0.333333333333	GATAD2B RBBP4 RBBP7	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
GO:0000118	0.0020721506318	0.444444444444	GATAD2B RBBP7 RBBP4 CHD5	histone deacetylase complex
GO:0031010	0.00292902387419	0.333333333333	RBBP7 RBBP4 BPTF	ISWI-type complex
REAC:R-HSA-3214815	0.00307013622401	0.333333333333	GATAD2B RBBP4 RBBP7	HDACs deacetylate histones
CORUM:282	0.00326883477195	0.222222222222	RBBP4 RBBP7	SNF2h-cohesin-NuRD complex
CORUM:739	0.00326883477195	0.222222222222	RBBP4 RBBP7	SIN3-ING1b complex II
CORUM:2721	0.00326883477195	0.222222222222	RBBP4 RBBP7	HCF-1 complex
HPA:0471383	0.00335063005611	0.222222222222	RBBP4 RBBP7	skin 2; arrector pili muscle cells[High]
GO:0006325	0.00341845413627	0.666666666667	RBBP7 PWWP2B GATAD2B RBBP4 CHD5 BPTF	chromatin organization
WP:WP2916	0.00367445660497	0.222222222222	RBBP4 RBBP7	Interactome of polycomb repressive complex 2 PRC2
REAC:R-HSA-9679191	0.00368511987685	0.333333333333	GATAD2B RBBP4 RBBP7	Potential therapeutics for SARS
CORUM:632	0.00370349612966	0.222222222222	RBBP4 RBBP7	Anti-HDAC2 complex
GO:0045892	0.00402753166504	0.777777777778	RBBP7 ZNF512B GATAD2B RBBP4 ZBTB2 CHD5 BPTF	negative regulation of DNA-templated transcription
GO:1902679	0.00436069320891	0.777777777778	RBBP7 ZNF512B GATAD2B RBBP4 ZBTB2 CHD5 BPTF	negative regulation of RNA biosynthetic process
CORUM:778	0.00465362752882	0.222222222222	GATAD2B RBBP4	LARC complex (LCR-associated remodeling complex)
REAC:R-HSA-5250913	0.00482963386549	0.333333333333	GATAD2B RBBP4 RBBP7	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-73854	0.00565197376137	0.333333333333	GATAD2B RBBP4 RBBP7	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.00582679710393	0.333333333333	GATAD2B RBBP4 RBBP7	RNA Polymerase I Transcription
GO:0042659	0.00655807506899	0.333333333333	GATAD2B RBBP4 RBBP7	regulation of cell fate specification
GO:0071824	0.00818347254642	0.666666666667	RBBP7 PWWP2B GATAD2B RBBP4 CHD5 BPTF	protein-DNA complex organization
GO:0051253	0.00857468875426	0.777777777778	RBBP7 ZNF512B GATAD2B RBBP4 ZBTB2 CHD5 BPTF	negative regulation of RNA metabolic process
CORUM:1257	0.0102574305302	0.222222222222	RBBP4 RBBP7	ALL-1 supercomplex
HPA:0471433	0.0108334058204	0.222222222222	RBBP4 RBBP7	skin 2; extracellular matrix[High]
REAC:R-HSA-6807070	0.0147316962319	0.333333333333	GATAD2B RBBP4 RBBP7	PTEN Regulation
GO:0010453	0.0162365457737	0.333333333333	GATAD2B RBBP4 RBBP7	regulation of cell fate commitment
GO:0045934	0.0171373333617	0.777777777778	RBBP7 ZNF512B GATAD2B RBBP4 ZBTB2 CHD5 BPTF	negative regulation of nucleobase-containing compound metabolic process
WP:WP4320	0.0202568688475	0.222222222222	RBBP4 RBBP7	Effect of progerin on genes involved in Hutchinson Gilford progeria syndrome
GO:0000122	0.0206219094099	0.666666666667	RBBP7 GATAD2B RBBP4 ZBTB2 CHD5 BPTF	negative regulation of transcription by RNA polymerase II
REAC:R-HSA-5633007	0.0209695640384	0.333333333333	GATAD2B RBBP4 RBBP7	Regulation of TP53 Activity
HPA:0471382	0.0225367284164	0.222222222222	RBBP4 RBBP7	skin 2; arrector pili muscle cells[>=Medium]
REAC:R-HSA-212165	0.0297477434643	0.333333333333	GATAD2B RBBP4 RBBP7	Epigenetic regulation of gene expression
HPA:0471483	0.0332185123571	0.222222222222	RBBP4 RBBP7	skin 2; sebaceous glands[High]
HPA:0471432	0.036644700733	0.222222222222	RBBP4 RBBP7	skin 2; extracellular matrix[>=Medium]
REAC:R-HSA-8953750	0.0443583465173	0.222222222222	RBBP4 RBBP7	Transcriptional Regulation by E2F6
HPA:0471453	0.0459345877268	0.222222222222	RBBP4 RBBP7	skin 2; hair follicles[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CHD5	GATAD2B	1.0	0.326		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
RBBP7	CHD5	1.0	0.134	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
RBBP4	RBBP7	1.0	0.664	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
RBBP4	GATAD2B	1.0	0.378		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM
RBBP7	GATAD2B	0.999	0.104		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
RBBP4	CHD5	0.999	0.382		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
BPTF	RBBP7	0.999	0.094		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
ZBTB2	GATAD2B	0.999	0.157272727273		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
RBBP4	PWWP2B	0.996		structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
RBBP4	BPTF	0.995	0.214		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
RBBP4	ZBTB2	0.993	0.264		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SHPRH	RBBP7	0.993	0.218	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
PWWP2B	RBBP7	0.99			bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
RBBP7	ZBTB2	0.99	0.227130434783	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ZNF512B	GATAD2B	0.986	0.082		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
ZNF512B	RBBP7	0.984	0.132		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
RBBP4	ZNF512B	0.979	0.294		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
RBBP4	SMARCA1	0.972	0.216		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
RBBP4	SHPRH	0.969	0.119	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	RBBP7	0.965	0.086		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
ZBTB2	CHD5	0.952	0.134		bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	BPTF	0.933	0.214		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
PWWP2B	CHD5	0.854			bioplex_WMM bioplex3_WMM WMM_only
BPTF	CHD5	0.847	0.548		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
BPTF	GATAD2B	0.818	0.304		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
ZNF512B	SHPRH	0.697	0.146		bioplex_WMM bioplex3_WMM WMM_only
PWWP2B	GATAD2B	0.659			bioplex_WMM bioplex3_WMM youn_WMM WMM_only
PWWP2B	ZBTB2	0.654			bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	PWWP2B	0.595			bioplex3_WMM WMM_only
BPTF	PWWP2B	0.555			bioplex3_WMM youn_WMM WMM_only
BPTF	ZBTB2	0.511	0.254		bioplex_WMM bioplex3_WMM WMM_only
BPTF	ZNF512B	0.405	0.292		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ZNF512B	CHD5	0.391	0.226		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
SHPRH	CHD5	0.378	0.138		bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	GATAD2B	0.366	0.184		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
SMARCA1	ZNF512B	0.361	0.172		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
SMARCA1	SHPRH	0.324	0.046		bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	CHD5	0.311	0.1		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
BPTF	SHPRH	0.283	0.066		bioplex_WMM bioplex3_WMM WMM_only
SHPRH	ZBTB2	0.257	0.094	structurally_consistent (Q16576)	bioplex_WMM bioplex3_WMM WMM_only
SMARCA1	ZBTB2	0.245	0.116		bioplex_WMM bioplex3_WMM WMM_only
PWWP2B	ZNF512B	0.241			bioplex_WMM bioplex3_WMM WMM_only
ZNF512B	ZBTB2	0.217	0.074		bioplex_WMM bioplex3_WMM WMM_only
SHPRH	GATAD2B	0.134	0.06		bioplex_WMM bioplex3_WMM WMM_only
PWWP2B	SHPRH	0.106		mutually_exclusive (Q09028)	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
GATAD2B	huMAP3_06728.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_15128.1
RBBP4	huMAP3_00206.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_12711.1 huMAP3_13482.1 huMAP3_15128.1
SMARCA1	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08549.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_13516.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
BPTF	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08833.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_10593.1 huMAP3_13482.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
CHD5	huMAP3_03905.1 huMAP3_06728.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
ZBTB2	huMAP3_00766.1 huMAP3_04896.1 huMAP3_06728.1 huMAP3_08906.1 huMAP3_09164.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_11045.1 huMAP3_12513.1 huMAP3_15128.1
RBBP7	huMAP3_00429.1 huMAP3_04616.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08800.1 huMAP3_08906.1 huMAP3_09031.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
PWWP2B	huMAP3_00206.1 huMAP3_00429.1 huMAP3_03441.1 huMAP3_06728.1 huMAP3_06889.1 huMAP3_07158.1 huMAP3_07299.1 huMAP3_08290.1 huMAP3_08800.1 huMAP3_08906.1 huMAP3_09031.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
ZNF512B	huMAP3_00206.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_13875.1 huMAP3_15128.1
SHPRH	huMAP3_00429.1 huMAP3_04616.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_12711.1 huMAP3_13482.1 huMAP3_15128.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06728.1

Complex Portal: CPX-19326