hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06746.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DRAP1 | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | 5 | UniProt NCBI |
| POLE4 | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | 5 | UniProt NCBI |
| CHRAC1 | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | 5 | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | 5 | UniProt NCBI |
| POLE3 | DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | 5 | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008622 | 5.40263452382e-14 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | epsilon DNA polymerase complex |
| REAC:R-HSA-68952 | 1.01530006227e-10 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA replication initiation |
| GO:0003887 | 6.27716685072e-10 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | DNA-directed DNA polymerase activity |
| CORUM:1108 | 6.85948670082e-10 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (15 subunits) |
| GO:0042575 | 8.36907803204e-10 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | DNA polymerase complex |
| CORUM:1111 | 9.60222926223e-10 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 9.60222926223e-10 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (17 subunits) |
| GO:0034061 | 2.86714523046e-09 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | DNA polymerase activity |
| WP:WP531 | 5.00388409863e-09 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA mismatch repair |
| REAC:R-HSA-5651801 | 8.66845929073e-09 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | PCNA-Dependent Long Patch Base Excision Repair |
| WP:WP4752 | 1.54744482581e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Base excision repair |
| REAC:R-HSA-5696397 | 1.83137742797e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 1.83137742797e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 2.39832142563e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA replication |
| REAC:R-HSA-110314 | 3.96532736613e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 4.55228403166e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Termination of translesion DNA synthesis |
| KEGG:03410 | 5.02078982671e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Base excision repair |
| REAC:R-HSA-68962 | 5.91891333952e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Activation of the pre-replicative complex |
| WP:WP4753 | 6.95851215581e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Nucleotide excision repair |
| REAC:R-HSA-73933 | 7.57200209391e-08 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 1.06711884519e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 1.46354483332e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Dual Incision in GG-NER |
| KEGG:03420 | 1.7232523415e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Nucleotide excision repair |
| REAC:R-HSA-73893 | 2.57601805302e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA Damage Bypass |
| WP:WP5114 | 6.1169608966e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-6782210 | 8.58772945408e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 9.15923852975e-07 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 1.03872291526e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-73884 | 1.84703047247e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Base Excision Repair |
| REAC:R-HSA-6781827 | 1.94802346798e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 2.64348795346e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| WP:WP4946 | 3.60267251917e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA repair pathways full network |
| GO:0016779 | 3.64951338667e-06 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | nucleotidyltransferase activity |
| REAC:R-HSA-5696398 | 7.68808827861e-06 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 1.13779051056e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Synthesis of DNA |
| REAC:R-HSA-5693567 | 1.3002582966e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 1.57574096812e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Homology Directed Repair |
| REAC:R-HSA-69206 | 1.62558528405e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | G1/S Transition |
| GO:0006261 | 2.31741536755e-05 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | DNA-templated DNA replication |
| REAC:R-HSA-69002 | 2.66716224853e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 2.66716224853e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-5693532 | 3.56561563648e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69242 | 3.65722772768e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | S Phase |
| REAC:R-HSA-69306 | 5.25380471613e-05 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA Replication |
| GO:0000228 | 6.51851913963e-05 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | nuclear chromosome |
| CORUM:234 | 0.000102488289015 | 0.333333333333 | CHRAC1 POLE3 | HuCHRAC complex |
| GO:0140097 | 0.000113200789661 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | catalytic activity, acting on DNA |
| GO:0006260 | 0.000195002899367 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | DNA replication |
| REAC:R-HSA-73894 | 0.000502730176626 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | DNA Repair |
| GO:0061695 | 0.000684514612873 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | transferase complex, transferring phosphorus-containing groups |
| CORUM:6665 | 0.00155157094875 | 0.333333333333 | POLE4 POLE3 | ATAC complex, YEATS2-linked |
| REAC:R-HSA-69278 | 0.00431798725585 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Cell Cycle, Mitotic |
| WP:WP466 | 0.00861234767009 | 0.333333333333 | POLE2 POLE | DNA replication |
| GO:0140513 | 0.0092737157774 | 1.0 | POLE4 DRAP1 POLE3 POLE2 POLE CHRAC1 | nuclear protein-containing complex |
| REAC:R-HSA-1640170 | 0.00977124360658 | 0.666666666667 | POLE4 POLE3 POLE POLE2 | Cell Cycle |
| GO:0140640 | 0.0126169815669 | 0.833333333333 | POLE4 POLE3 POLE2 POLE CHRAC1 | catalytic activity, acting on a nucleic acid |
| WP:WP45 | 0.0200845776786 | 0.333333333333 | POLE2 POLE | G1 to S cell cycle control |
| WP:WP2446 | 0.0362670507824 | 0.333333333333 | POLE2 POLE | Retinoblastoma gene in cancer |
| KEGG:03082 | 0.0382199966286 | 0.333333333333 | CHRAC1 POLE3 | ATP-dependent chromatin remodeling |
| GO:0006272 | 0.042122686785 | 0.333333333333 | POLE3 POLE | leading strand elongation |
| GO:0008623 | 0.042122686785 | 0.333333333333 | CHRAC1 POLE3 | CHRAC |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| POLE2 | POLE | 1.0 | 0.358 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| POLE4 | POLE2 | 1.0 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POLE4 | POLE3 | 0.999 | 0.326 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| CHRAC1 | POLE3 | 0.999 | 0.956 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| POLE3 | POLE | 0.999 | 0.108 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| POLE2 | POLE3 | 0.998 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POLE4 | POLE | 0.995 | 0.112 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| POLE3 | DRAP1 | 0.973 | 0.082 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| POLE2 | DRAP1 | 0.829 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| POLE4 | CHRAC1 | 0.274 | 0.19 | bioplex3_WMM WMM_only |
| POLE4 | DRAP1 | 0.201 | 0.098 | bioplex3_WMM WMM_only |
| CHRAC1 | DRAP1 | 0.186 | 0.172 | bioplex3_WMM WMM_only |
| POLE | DRAP1 | 0.168 | 0.022 | bioplex3_WMM WMM_only |
| CHRAC1 | POLE2 | 0.167 | 0.116 | bioplex3_WMM WMM_only |
| CHRAC1 | POLE | 0.146 | 0.02 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DRAP1 | huMAP3_06746.1 huMAP3_07366.1 huMAP3_14197.1 |
| POLE4 | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |
| CHRAC1 | huMAP3_04178.1 huMAP3_06403.1 huMAP3_06746.1 huMAP3_13332.1 huMAP3_15153.1 |
| POLE2 | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |
| POLE3 | huMAP3_04178.1 huMAP3_06403.1 huMAP3_06746.1 huMAP3_14197.1 |
| POLE | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |